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• W2801653583 endingPage "146" @default.
• W2801653583 startingPage "139" @default.
• W2801653583 abstract "Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci and over 60 identified genes. Studies investigating the molecular pathogenesis underlying HSPs have emphasized the importance of converging cellular pathogenic themes in the most common forms of HSP, providing compelling targets for therapy. Most notably, these include organelle shaping and biogenesis as well as membrane and cargo trafficking." @default.
• W2801653583 created "2018-05-17" @default.
• W2801653583 creator A5059540944 @default.
• W2801653583 date "2018-08-01" @default.
• W2801653583 modified "2023-10-12" @default.
• W2801653583 title "Converging cellular themes for the hereditary spastic paraplegias" @default.
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• W2801653583 doi "https://doi.org/10.1016/j.conb.2018.04.025" @default.
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