FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801662647> ?p ?o ?g. }

• W2801662647 endingPage "138" @default.
• W2801662647 startingPage "129" @default.
• W2801662647 abstract "Burrowing is a rodent behavior validated as a robust and reproducible outcome measure to infer the global effect of pain in several inflammatory pain models. However, less is known about the effect of analgesics on burrowing in neuropathic pain models and no studies have determined burrowing performance in models of diabetes-associated neuropathic pain.To compare the sensitivity of the burrowing assay in different neuropathic pain models: mononeuropathic pain and diabetic polyneuropathy.Burrowing performance was determined by the amount of substrate left in a hollow tube by rats with chronic constriction injury (CCI). In addition, burrowing performance, locomotion and pain development was assessed in the Zucker diabetic fatty (ZDF) rat model, resembling type-2 diabetes. Efficacy of clinically-active reference drugs (opioids, gabapentin and/or pregabalin) were investigated in these models. Burrowing behavior was additionally assessed in a second model, induced by streptozotocin (STZ) treatment, resembling type-1 diabetes.In the CCI model, moderate but consistent burrowing deficits were observed that persisted over a period of ≥20 days. Systemic administration of morphine, pregabalin and gabapentin reversed this deficit. In contrast, none of the reference drugs improved marked burrowing deficits detected in ZDF rats, and pregabalin did not reverse severe burrowing deficits observed in STZ rats.Burrowing performance cannot necessarily be used as pain-related readout across pain models and largely depends on the model used, at least in models of neuropathy. Specifically, analgesic drug effects might be masked by general diabetes-associated alteration of the animals' well-being, resulting in false negative outcomes." @default.
• W2801662647 created "2018-05-17" @default.
• W2801662647 creator A5008648481 @default.
• W2801662647 creator A5047056425 @default.
• W2801662647 creator A5073460030 @default.
• W2801662647 creator A5078669522 @default.
• W2801662647 creator A5087777763 @default.
• W2801662647 creator A5088615278 @default.
• W2801662647 date "2018-09-01" @default.
• W2801662647 modified "2023-10-14" @default.
• W2801662647 title "Standard analgesics reverse burrowing deficits in a rat CCI model of neuropathic pain, but not in models of type 1 and type 2 diabetes-induced neuropathic pain" @default.
• W2801662647 cites W1507098814 @default.
• W2801662647 cites W1539841279 @default.
• W2801662647 cites W1583390202 @default.
• W2801662647 cites W1791192920 @default.
• W2801662647 cites W1836565602 @default.
• W2801662647 cites W1916800927 @default.
• W2801662647 cites W1941743200 @default.
• W2801662647 cites W1964790300 @default.
• W2801662647 cites W1970720793 @default.
• W2801662647 cites W1979801278 @default.
• W2801662647 cites W1982326881 @default.
• W2801662647 cites W1983873279 @default.
• W2801662647 cites W1986910347 @default.
• W2801662647 cites W1993480354 @default.
• W2801662647 cites W1993773911 @default.
• W2801662647 cites W1995723411 @default.
• W2801662647 cites W1997834275 @default.
• W2801662647 cites W2001545679 @default.
• W2801662647 cites W2004340905 @default.
• W2801662647 cites W2006301331 @default.
• W2801662647 cites W2006944478 @default.
• W2801662647 cites W2012618280 @default.
• W2801662647 cites W2017299617 @default.
• W2801662647 cites W2018459912 @default.
• W2801662647 cites W2018636748 @default.
• W2801662647 cites W2031393964 @default.
• W2801662647 cites W2035413305 @default.
• W2801662647 cites W2037477404 @default.
• W2801662647 cites W2037829509 @default.
• W2801662647 cites W2058020736 @default.
• W2801662647 cites W2061077377 @default.
• W2801662647 cites W2062174971 @default.
• W2801662647 cites W2069423981 @default.
• W2801662647 cites W2070382190 @default.
• W2801662647 cites W2072701076 @default.
• W2801662647 cites W2073050255 @default.
• W2801662647 cites W2080093346 @default.
• W2801662647 cites W2082504230 @default.
• W2801662647 cites W2084573288 @default.
• W2801662647 cites W2087454739 @default.
• W2801662647 cites W2087685632 @default.
• W2801662647 cites W2094310013 @default.
• W2801662647 cites W2096877115 @default.
• W2801662647 cites W2103351070 @default.
• W2801662647 cites W2113484322 @default.
• W2801662647 cites W2115601182 @default.
• W2801662647 cites W2124985912 @default.
• W2801662647 cites W2131231032 @default.
• W2801662647 cites W2132223509 @default.
• W2801662647 cites W2138287382 @default.
• W2801662647 cites W2139090458 @default.
• W2801662647 cites W2139398649 @default.
• W2801662647 cites W2150524206 @default.
• W2801662647 cites W2150803160 @default.
• W2801662647 cites W2154900807 @default.
• W2801662647 cites W2155248498 @default.
• W2801662647 cites W2172201406 @default.
• W2801662647 cites W2201813048 @default.
• W2801662647 cites W2364090267 @default.
• W2801662647 cites W2520219328 @default.
• W2801662647 cites W2625050957 @default.
• W2801662647 cites W2736383794 @default.
• W2801662647 cites W567449897 @default.
• W2801662647 doi "https://doi.org/10.1016/j.bbr.2018.04.049" @default.
• W2801662647 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29738803" @default.
• W2801662647 hasPublicationYear "2018" @default.
• W2801662647 type Work @default.
• W2801662647 sameAs 2801662647 @default.
• W2801662647 citedByCount "21" @default.
• W2801662647 countsByYear W28016626472019 @default.
• W2801662647 countsByYear W28016626472020 @default.
• W2801662647 countsByYear W28016626472021 @default.
• W2801662647 countsByYear W28016626472022 @default.
• W2801662647 countsByYear W28016626472023 @default.
• W2801662647 crossrefType "journal-article" @default.
• W2801662647 hasAuthorship W2801662647A5008648481 @default.
• W2801662647 hasAuthorship W2801662647A5047056425 @default.
• W2801662647 hasAuthorship W2801662647A5073460030 @default.
• W2801662647 hasAuthorship W2801662647A5078669522 @default.
• W2801662647 hasAuthorship W2801662647A5087777763 @default.
• W2801662647 hasAuthorship W2801662647A5088615278 @default.
• W2801662647 hasBestOaLocation W28016626471 @default.
• W2801662647 hasConcept C126322002 @default.
• W2801662647 hasConcept C134018914 @default.
• W2801662647 hasConcept C142724271 @default.
• W2801662647 hasConcept C204787440 @default.
• W2801662647 hasConcept C2776468701 @default.

• next