Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801666001> ?p ?o ?g. }
- W2801666001 endingPage "1685" @default.
- W2801666001 startingPage "1669" @default.
- W2801666001 abstract "Low-density lipoprotein (LDL) receptor-related protein-1 (LRP1) is expressed in retinal Müller glial cells (MGCs) and regulates intracellular translocation to the plasma membrane (PM) of the membrane proteins involved in cellular motility and activity. Different functions of MGCs may be influenced by insulin, including the removal of extracellular glutamate in the retina. In the present work, we investigated whether insulin promotes LRP1 translocation to the PM in the Müller glial-derived cell line MIO-M1 (human retinal Müller glial cell-derived cell line). We demonstrated that LRP1 is stored in small vesicles containing an approximate size of 100 nm (mean diameter range of 100–120 nm), which were positive for sortilin and VAMP2, and also incorporated GLUT4 when it was transiently transfected. Next, we observed that LRP1 translocation to the PM was promoted by insulin-regulated exocytosis through intracellular activation of the IR/PI3K/Akt axis and Rab-GTPase proteins such as Rab8A and Rab10. In addition, these Rab-GTPases regulated both the constitutive and insulin-induced LRP1 translocation to the PM. Finally, we found that dominant-negative Rab8A and Rab10 mutants impaired insulin-induced intracellular signaling of the IR/PI3K/Akt axis, suggesting that these GTPase proteins as well as the LRP1 level at the cell surface are involved in insulin-induced IR activation." @default.
- W2801666001 created "2018-05-17" @default.
- W2801666001 creator A5006244021 @default.
- W2801666001 creator A5020234449 @default.
- W2801666001 creator A5051517748 @default.
- W2801666001 creator A5063184441 @default.
- W2801666001 creator A5076381466 @default.
- W2801666001 date "2018-05-15" @default.
- W2801666001 modified "2023-10-08" @default.
- W2801666001 title "Insulin-induced exocytosis regulates the cell surface level of low-density lipoprotein-related protein-1 in Müller Glial cells" @default.
- W2801666001 cites W1541704381 @default.
- W2801666001 cites W1565493424 @default.
- W2801666001 cites W1584783298 @default.
- W2801666001 cites W1923431801 @default.
- W2801666001 cites W1964208108 @default.
- W2801666001 cites W1964445339 @default.
- W2801666001 cites W1968639426 @default.
- W2801666001 cites W1981087370 @default.
- W2801666001 cites W1981180774 @default.
- W2801666001 cites W1987942705 @default.
- W2801666001 cites W1992906306 @default.
- W2801666001 cites W1995230613 @default.
- W2801666001 cites W1998236766 @default.
- W2801666001 cites W2005527680 @default.
- W2801666001 cites W2005753856 @default.
- W2801666001 cites W2006300948 @default.
- W2801666001 cites W2018358706 @default.
- W2801666001 cites W2034234265 @default.
- W2801666001 cites W2035542007 @default.
- W2801666001 cites W2037532481 @default.
- W2801666001 cites W2043270630 @default.
- W2801666001 cites W2049806614 @default.
- W2801666001 cites W2068627446 @default.
- W2801666001 cites W2073650157 @default.
- W2801666001 cites W2074427850 @default.
- W2801666001 cites W2079008207 @default.
- W2801666001 cites W2083020365 @default.
- W2801666001 cites W2083493656 @default.
- W2801666001 cites W2087816256 @default.
- W2801666001 cites W2090458886 @default.
- W2801666001 cites W2091265738 @default.
- W2801666001 cites W2094663320 @default.
- W2801666001 cites W2098974443 @default.
- W2801666001 cites W2117152988 @default.
- W2801666001 cites W2119856031 @default.
- W2801666001 cites W2124733101 @default.
- W2801666001 cites W2132099317 @default.
- W2801666001 cites W2138307264 @default.
- W2801666001 cites W2140381876 @default.
- W2801666001 cites W2146262948 @default.
- W2801666001 cites W2147263604 @default.
- W2801666001 cites W2147457445 @default.
- W2801666001 cites W2150555592 @default.
- W2801666001 cites W2151918182 @default.
- W2801666001 cites W2158409776 @default.
- W2801666001 cites W2162401979 @default.
- W2801666001 cites W2179881030 @default.
- W2801666001 cites W2334133751 @default.
- W2801666001 cites W2562141642 @default.
- W2801666001 cites W2609258705 @default.
- W2801666001 cites W2622101734 @default.
- W2801666001 cites W4211214945 @default.
- W2801666001 cites W4248025115 @default.
- W2801666001 doi "https://doi.org/10.1042/bcj20170891" @default.
- W2801666001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29669912" @default.
- W2801666001 hasPublicationYear "2018" @default.
- W2801666001 type Work @default.
- W2801666001 sameAs 2801666001 @default.
- W2801666001 citedByCount "10" @default.
- W2801666001 countsByYear W28016660012018 @default.
- W2801666001 countsByYear W28016660012019 @default.
- W2801666001 countsByYear W28016660012020 @default.
- W2801666001 countsByYear W28016660012021 @default.
- W2801666001 countsByYear W28016660012022 @default.
- W2801666001 crossrefType "journal-article" @default.
- W2801666001 hasAuthorship W2801666001A5006244021 @default.
- W2801666001 hasAuthorship W2801666001A5020234449 @default.
- W2801666001 hasAuthorship W2801666001A5051517748 @default.
- W2801666001 hasAuthorship W2801666001A5063184441 @default.
- W2801666001 hasAuthorship W2801666001A5076381466 @default.
- W2801666001 hasConcept C134018914 @default.
- W2801666001 hasConcept C139647698 @default.
- W2801666001 hasConcept C156728348 @default.
- W2801666001 hasConcept C161573976 @default.
- W2801666001 hasConcept C163181125 @default.
- W2801666001 hasConcept C175969161 @default.
- W2801666001 hasConcept C207332259 @default.
- W2801666001 hasConcept C2776188179 @default.
- W2801666001 hasConcept C2778163477 @default.
- W2801666001 hasConcept C2779306644 @default.
- W2801666001 hasConcept C2780072125 @default.
- W2801666001 hasConcept C43554185 @default.
- W2801666001 hasConcept C49039625 @default.
- W2801666001 hasConcept C62478195 @default.
- W2801666001 hasConcept C75217442 @default.
- W2801666001 hasConcept C79879829 @default.
- W2801666001 hasConcept C80631254 @default.
- W2801666001 hasConcept C86803240 @default.