Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801673736> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2801673736 endingPage "239" @default.
- W2801673736 startingPage "233" @default.
- W2801673736 abstract "Use of immune therapy in metastatic cancers is rapidly expanding; however, its combination with commonly prescribed palliative radiation fields and doses is not well studied. To investigate this, we evaluated the toxicity of combined immune therapy and palliative cervical or thoracic spine radiotherapy. Patients receiving cervical or thoracic spine radiation were evaluated based on administration of immune therapy within 30 days of radiation, use of 3D conformal or simpler techniques, and minimum 1 follow-up from end of treatment. Thirty patients were evaluable. Median survival following radiotherapy was 87 days. Pembrolizumab was most commonly combined with radiation (11 patients), then nivolumab (10), ipilimumab (3), and atezoliumab (2). Four patients (13.3%) had grade 3 toxicity requiring hospitalization (vomiting, esophagitis) and 12 patients (40%) had grade 2 toxicity (esophagitis, dysphagia). Ten patients (33.3%) had no toxicity. Three of the 4 patients with grade 3 toxicity received concurrent ipilimumab and nivolumab. Median dose was 30 Gy (range, 20–39) and fractions were 10 (range, 5–15). There was a trend toward increased grade 2+ toxicity with greater number of vertebral levels irradiated, 5.7 ± 3.4, vs. 4.0 ± 1.6 for none/grade 1 (P = .086). Seven of 7 patients exposed to ipilimumab developed grade 2+ toxicity vs 39% in the remaining patients (P = .007 for interaction). Radiation dose, fractionation, and timing of immune therapy were not significant contributors. Combined immune therapy and radiotherapy for palliation of spine metastases suggests increased toxicity when a greater number of vertebral bodies are irradiated, or when combined immune therapy agents are utilized." @default.
- W2801673736 created "2018-05-17" @default.
- W2801673736 creator A5017346791 @default.
- W2801673736 creator A5039052702 @default.
- W2801673736 creator A5039108982 @default.
- W2801673736 creator A5061348241 @default.
- W2801673736 creator A5070444608 @default.
- W2801673736 creator A5090230371 @default.
- W2801673736 date "2018-05-03" @default.
- W2801673736 modified "2023-10-12" @default.
- W2801673736 title "Tolerability of sequential immune therapy and palliative radiotherapy to the cervical and thoracic spine" @default.
- W2801673736 cites W1990811913 @default.
- W2801673736 cites W2032166347 @default.
- W2801673736 cites W2099674544 @default.
- W2801673736 cites W2127436102 @default.
- W2801673736 cites W2128650447 @default.
- W2801673736 cites W2170161732 @default.
- W2801673736 cites W2326574449 @default.
- W2801673736 cites W2415633845 @default.
- W2801673736 cites W2461739654 @default.
- W2801673736 cites W2527129822 @default.
- W2801673736 cites W2564183539 @default.
- W2801673736 cites W2578888194 @default.
- W2801673736 cites W2579913000 @default.
- W2801673736 cites W2587330058 @default.
- W2801673736 cites W2594491432 @default.
- W2801673736 cites W2715315455 @default.
- W2801673736 cites W2751602305 @default.
- W2801673736 cites W2778515596 @default.
- W2801673736 cites W4247210792 @default.
- W2801673736 doi "https://doi.org/10.1007/s13566-018-0352-9" @default.
- W2801673736 hasPublicationYear "2018" @default.
- W2801673736 type Work @default.
- W2801673736 sameAs 2801673736 @default.
- W2801673736 citedByCount "2" @default.
- W2801673736 countsByYear W28016737362022 @default.
- W2801673736 crossrefType "journal-article" @default.
- W2801673736 hasAuthorship W2801673736A5017346791 @default.
- W2801673736 hasAuthorship W2801673736A5039052702 @default.
- W2801673736 hasAuthorship W2801673736A5039108982 @default.
- W2801673736 hasAuthorship W2801673736A5061348241 @default.
- W2801673736 hasAuthorship W2801673736A5070444608 @default.
- W2801673736 hasAuthorship W2801673736A5090230371 @default.
- W2801673736 hasBestOaLocation W28016737361 @default.
- W2801673736 hasConcept C121608353 @default.
- W2801673736 hasConcept C126322002 @default.
- W2801673736 hasConcept C141071460 @default.
- W2801673736 hasConcept C143998085 @default.
- W2801673736 hasConcept C197934379 @default.
- W2801673736 hasConcept C2777701055 @default.
- W2801673736 hasConcept C2778375690 @default.
- W2801673736 hasConcept C2779134260 @default.
- W2801673736 hasConcept C2779920096 @default.
- W2801673736 hasConcept C2780030458 @default.
- W2801673736 hasConcept C2781433595 @default.
- W2801673736 hasConcept C29730261 @default.
- W2801673736 hasConcept C43270747 @default.
- W2801673736 hasConcept C509974204 @default.
- W2801673736 hasConcept C71924100 @default.
- W2801673736 hasConcept C90924648 @default.
- W2801673736 hasConceptScore W2801673736C121608353 @default.
- W2801673736 hasConceptScore W2801673736C126322002 @default.
- W2801673736 hasConceptScore W2801673736C141071460 @default.
- W2801673736 hasConceptScore W2801673736C143998085 @default.
- W2801673736 hasConceptScore W2801673736C197934379 @default.
- W2801673736 hasConceptScore W2801673736C2777701055 @default.
- W2801673736 hasConceptScore W2801673736C2778375690 @default.
- W2801673736 hasConceptScore W2801673736C2779134260 @default.
- W2801673736 hasConceptScore W2801673736C2779920096 @default.
- W2801673736 hasConceptScore W2801673736C2780030458 @default.
- W2801673736 hasConceptScore W2801673736C2781433595 @default.
- W2801673736 hasConceptScore W2801673736C29730261 @default.
- W2801673736 hasConceptScore W2801673736C43270747 @default.
- W2801673736 hasConceptScore W2801673736C509974204 @default.
- W2801673736 hasConceptScore W2801673736C71924100 @default.
- W2801673736 hasConceptScore W2801673736C90924648 @default.
- W2801673736 hasIssue "3" @default.
- W2801673736 hasLocation W28016737361 @default.
- W2801673736 hasOpenAccess W2801673736 @default.
- W2801673736 hasPrimaryLocation W28016737361 @default.
- W2801673736 hasRelatedWork W2155654588 @default.
- W2801673736 hasRelatedWork W2323005616 @default.
- W2801673736 hasRelatedWork W2767198352 @default.
- W2801673736 hasRelatedWork W2947988614 @default.
- W2801673736 hasRelatedWork W3032186543 @default.
- W2801673736 hasRelatedWork W4226292283 @default.
- W2801673736 hasRelatedWork W4242847743 @default.
- W2801673736 hasRelatedWork W4312069968 @default.
- W2801673736 hasRelatedWork W4318473990 @default.
- W2801673736 hasRelatedWork W4319293879 @default.
- W2801673736 hasVolume "7" @default.
- W2801673736 isParatext "false" @default.
- W2801673736 isRetracted "false" @default.
- W2801673736 magId "2801673736" @default.
- W2801673736 workType "article" @default.