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- W2801676853 abstract "Abstract Inflammatory rheumatic diseases, such as rheumatoid arthritis or spondylarthritides and systemic autoimmune diseases, including connective tissue diseases like systemic lupus erythematosus and vasculitides, are chronic conditions. Accordingly, these patients usually are under long-term treatment with immunomodulating or immunosuppressive drugs, and often with glucocorticoids. Many of these medications have the potential to also increase the risk of perioperative infections and potentially wound healing disturbances. Risks are usually low with conventional synthetic disease-modifying antirheumatic drugs (DMARDs), in dispute for leflunomide, moderate for biological DMARDs, and probably for Janus kinase inhibitors and potentially high for cyclophosphamide and higher-dose glucocorticoids. On the other hand, withdrawal over time will lead to flares, which may be life-threatening in systemic autoimmune disease or necessitate higher-dose glucocorticoids with even more untoward effects. Accordingly, time spacing is relevant for elective surgery, and the individual decision is both dependent on the nature of the underlying condition and the employed medication. Usually, direct communication with the treating rheumatologist will help optimizing perioperative management." @default.
- W2801676853 created "2018-05-17" @default.
- W2801676853 creator A5091190600 @default.
- W2801676853 date "2018-01-01" @default.
- W2801676853 modified "2023-09-27" @default.
- W2801676853 title "Essential and Optional Drugs for Rheumatic Diseases" @default.
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- W2801676853 doi "https://doi.org/10.1016/b978-0-444-63887-8.00004-9" @default.
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