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• W2801687867 endingPage "111" @default.
• W2801687867 startingPage "102" @default.
• W2801687867 abstract "Chemical exposures have been implicated as environmental risk factors that interact with genetic susceptibilities to influence individual risk for complex neurodevelopmental disorders, including autism spectrum disorder, schizophrenia, attention deficit hyperactivity disorder and intellectual disabilities. Altered patterns of neuronal connectivity represent a convergent mechanism of pathogenesis for these and other neurodevelopmental disorders, and growing evidence suggests that chemicals can interfere with specific signaling pathways that regulate the development of neuronal connections. There is, therefore, a growing interest in developing screening platforms to identify chemicals that alter neuronal connectivity. Cell-cell, cell-matrix interactions and systemic influences are known to be important in defining neuronal connectivity in the developing brain, thus, a systems-based model offers significant advantages over cell-based models for screening chemicals for effects on neuronal connectivity. The embryonic zebrafish represents a vertebrate model amenable to higher throughput chemical screening that has proven useful in characterizing conserved mechanisms of neurodevelopment. Moreover, the zebrafish is readily amenable to gene editing to integrate genetic susceptibilities. Although use of the zebrafish model in toxicity testing has increased in recent years, the diverse tools available for imaging structural differences in the developing zebrafish brain have not been widely applied to studies of the influence of gene by environment interactions on neuronal connectivity in the developing zebrafish brain. Here, we discuss tools available for imaging of neuronal connectivity in the developing zebrafish, review what has been published in this regard, and suggest a path forward for applying this information to developmental neurotoxicity testing." @default.
• W2801687867 created "2018-05-17" @default.
• W2801687867 creator A5002639772 @default.
• W2801687867 creator A5016628922 @default.
• W2801687867 creator A5069327095 @default.
• W2801687867 creator A5077820086 @default.
• W2801687867 date "2018-07-01" @default.
• W2801687867 modified "2023-09-30" @default.
• W2801687867 title "Opportunities and challenges for using the zebrafish to study neuronal connectivity as an endpoint of developmental neurotoxicity" @default.
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