FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801691965> ?p ?o ?g. }

• W2801691965 abstract "The present study aimed to investigate the effects of obatoclax (OBX) combined with gemcitabine (GEM) treatment on the proliferation, migration, invasion and epithelial‑mesenchymal transition (EMT) related proteins of pancreatic cancer cell line BxPC‑3 under hypoxic conditions. Protein expression levels of hypoxia‑inducible factor 1α (HIF‑1α) in BxPC‑3 pancreatic cancer cells under normoxic and hypoxic conditions were detected by western blotting. Cells were divided into four groups: Normoxia group, hypoxia group, OBX group and OBX + GEM group. The proliferation activity of BxPC‑3 cells was detected by Cell Counting kit‑8. The migratory and invasive abilities of BxPC‑3 cells were detected by the scratch test and Matrigel assay, respectively. The protein expression levels of vimentin, E‑cadherin and p53 in BxPC‑3 cells were also detected by western blotting. HIF‑1α expression under hypoxic conditions was significantly increased compared with expression under normoxic conditions. Under hypoxic conditions, OBX treatment reduced cell activity, decreased cell migration and invasion, promoted the expression of E‑cadherin and p53. In the OBX + GEM group, BxPC‑3 cell activity decreased significantly, cell migration and invasion decreased significantly, the expression of vimentin was significantly reduced and the expression of E‑cadherin and p53 further increased. In conclusion, the present results demonstrated that under hypoxic conditions, OBX combined with a small dose of GEM may be able to inhibit the growth, migration and invasion of pancreatic cancer cells, possibly via inhibition of EMT process. These results may provide a promising strategy for pancreatic cancer therapy." @default.
• W2801691965 created "2018-05-17" @default.
• W2801691965 creator A5005110304 @default.
• W2801691965 creator A5024396435 @default.
• W2801691965 creator A5035350525 @default.
• W2801691965 creator A5045591857 @default.
• W2801691965 creator A5049658960 @default.
• W2801691965 creator A5065912071 @default.
• W2801691965 date "2018-04-26" @default.
• W2801691965 modified "2023-09-28" @default.
• W2801691965 title "Effects of obatoclax combined with gemcitabine on the biological activity of pancreatic cancer cells under hypoxic conditions" @default.
• W2801691965 doi "https://doi.org/10.3892/mmr.2018.8932" @default.
• W2801691965 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29749486" @default.
• W2801691965 hasPublicationYear "2018" @default.
• W2801691965 type Work @default.
• W2801691965 sameAs 2801691965 @default.
• W2801691965 citedByCount "3" @default.
• W2801691965 countsByYear W28016919652021 @default.
• W2801691965 countsByYear W28016919652022 @default.
• W2801691965 crossrefType "journal-article" @default.
• W2801691965 hasAuthorship W2801691965A5005110304 @default.
• W2801691965 hasAuthorship W2801691965A5024396435 @default.
• W2801691965 hasAuthorship W2801691965A5035350525 @default.
• W2801691965 hasAuthorship W2801691965A5045591857 @default.
• W2801691965 hasAuthorship W2801691965A5049658960 @default.
• W2801691965 hasAuthorship W2801691965A5065912071 @default.
• W2801691965 hasBestOaLocation W28016919651 @default.
• W2801691965 hasConcept C104317684 @default.
• W2801691965 hasConcept C121608353 @default.
• W2801691965 hasConcept C126322002 @default.
• W2801691965 hasConcept C137738243 @default.
• W2801691965 hasConcept C147447768 @default.
• W2801691965 hasConcept C1491633281 @default.
• W2801691965 hasConcept C203014093 @default.
• W2801691965 hasConcept C204232928 @default.
• W2801691965 hasConcept C2778608917 @default.
• W2801691965 hasConcept C2779013556 @default.
• W2801691965 hasConcept C2780210213 @default.
• W2801691965 hasConcept C2780258809 @default.
• W2801691965 hasConcept C2780394083 @default.
• W2801691965 hasConcept C2781018059 @default.
• W2801691965 hasConcept C29537977 @default.
• W2801691965 hasConcept C502942594 @default.
• W2801691965 hasConcept C54355233 @default.
• W2801691965 hasConcept C55493867 @default.
• W2801691965 hasConcept C62112901 @default.
• W2801691965 hasConcept C71924100 @default.
• W2801691965 hasConcept C76419328 @default.
• W2801691965 hasConcept C85265743 @default.
• W2801691965 hasConcept C86803240 @default.
• W2801691965 hasConceptScore W2801691965C104317684 @default.
• W2801691965 hasConceptScore W2801691965C121608353 @default.
• W2801691965 hasConceptScore W2801691965C126322002 @default.
• W2801691965 hasConceptScore W2801691965C137738243 @default.
• W2801691965 hasConceptScore W2801691965C147447768 @default.
• W2801691965 hasConceptScore W2801691965C1491633281 @default.
• W2801691965 hasConceptScore W2801691965C203014093 @default.
• W2801691965 hasConceptScore W2801691965C204232928 @default.
• W2801691965 hasConceptScore W2801691965C2778608917 @default.
• W2801691965 hasConceptScore W2801691965C2779013556 @default.
• W2801691965 hasConceptScore W2801691965C2780210213 @default.
• W2801691965 hasConceptScore W2801691965C2780258809 @default.
• W2801691965 hasConceptScore W2801691965C2780394083 @default.
• W2801691965 hasConceptScore W2801691965C2781018059 @default.
• W2801691965 hasConceptScore W2801691965C29537977 @default.
• W2801691965 hasConceptScore W2801691965C502942594 @default.
• W2801691965 hasConceptScore W2801691965C54355233 @default.
• W2801691965 hasConceptScore W2801691965C55493867 @default.
• W2801691965 hasConceptScore W2801691965C62112901 @default.
• W2801691965 hasConceptScore W2801691965C71924100 @default.
• W2801691965 hasConceptScore W2801691965C76419328 @default.
• W2801691965 hasConceptScore W2801691965C85265743 @default.
• W2801691965 hasConceptScore W2801691965C86803240 @default.
• W2801691965 hasLocation W28016919651 @default.
• W2801691965 hasLocation W28016919652 @default.
• W2801691965 hasOpenAccess W2801691965 @default.
• W2801691965 hasPrimaryLocation W28016919651 @default.
• W2801691965 hasRelatedWork W1888189529 @default.
• W2801691965 hasRelatedWork W1968170015 @default.
• W2801691965 hasRelatedWork W2049611896 @default.
• W2801691965 hasRelatedWork W2142638537 @default.
• W2801691965 hasRelatedWork W2171945502 @default.
• W2801691965 hasRelatedWork W2295394896 @default.
• W2801691965 hasRelatedWork W2369733656 @default.
• W2801691965 hasRelatedWork W2460494782 @default.
• W2801691965 hasRelatedWork W2568154761 @default.
• W2801691965 hasRelatedWork W2767146279 @default.
• W2801691965 hasRelatedWork W2903244260 @default.
• W2801691965 hasRelatedWork W2941478635 @default.
• W2801691965 hasRelatedWork W2995652414 @default.
• W2801691965 hasRelatedWork W2997852206 @default.
• W2801691965 hasRelatedWork W3026785658 @default.
• W2801691965 hasRelatedWork W3107733740 @default.
• W2801691965 hasRelatedWork W3121481203 @default.
• W2801691965 hasRelatedWork W3153601200 @default.
• W2801691965 hasRelatedWork W3190035562 @default.
• W2801691965 hasRelatedWork W3210608186 @default.
• W2801691965 isParatext "false" @default.
• W2801691965 isRetracted "false" @default.
• W2801691965 magId "2801691965" @default.

• next