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- W2801696802 endingPage "5454" @default.
- W2801696802 startingPage "5441" @default.
- W2801696802 abstract "Mosquitoes transmit a diverse group of human flaviviruses including West Nile, dengue, yellow fever, and Zika viruses. Mosquitoes are also naturally infected with insect-specific flaviviruses (ISFs), a subgroup of the family not capable of infecting vertebrates. Although ISFs are not medically important, they are capable of altering the mosquito's susceptibility to flaviviruses and may alter host fitness. Wolbachia is an endosymbiotic bacterium of insects that when present in mosquitoes limits the replication of co-infecting pathogens, including flaviviruses. Artificially created Wolbachia-infected Aedes aegypti mosquitoes are being released into the wild in a series of trials around the globe with the hope of interrupting dengue and Zika virus transmission from mosquitoes to humans. Our work investigated the effect of Wolbachia on ISF infection in wild-caught Ae. aegypti mosquitoes from field release zones. All field mosquitoes were screened for the presence of ISFs using general degenerate flavivirus primers and their PCR amplicons sequenced. ISFs were found to be common and widely distributed in Ae. aegypti populations. Field mosquitoes consistently had higher ISF infection rates and viral loads compared to laboratory colony material indicating that environmental conditions may modulate ISF infection in Ae. aegypti. Surprisingly, higher ISF infection rates and loads were found in Wolbachia-infected mosquitoes compared to the Wolbachia-free mosquitoes. Our findings demonstrate that the symbiont is capable of manipulating the mosquito virome and that Wolbachia-mediated viral inhibition is not universal for flaviviruses. This may have implications for the Wolbachia-based DENV control strategy if ISFs confer fitness effects or alter mosquito susceptibility to other flaviviruses." @default.
- W2801696802 created "2018-05-17" @default.
- W2801696802 creator A5006723625 @default.
- W2801696802 creator A5017616220 @default.
- W2801696802 creator A5018645456 @default.
- W2801696802 creator A5061467634 @default.
- W2801696802 creator A5062848617 @default.
- W2801696802 creator A5081582718 @default.
- W2801696802 date "2018-05-08" @default.
- W2801696802 modified "2023-10-15" @default.
- W2801696802 title "<i>Wolbachia</i> enhances insect‐specific flavivirus infection in <i>Aedes aegypti</i> mosquitoes" @default.
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