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- W2801703535 abstract "Abstract The commonly used “stealth material” poly(ethylene glycol) (PEG) effectively promotes the pharmacokinetics of therapeutic cargos while reducing their immune response. However, recent studies have suggested that PEG could induce adverse reactions, including the emergence of anti‐PEG antibodies and tissue histologic changes. An alternative stealth material with no or less immunogenicity and organ toxicity is thus urgently needed. We designed a polypeptide with high zwitterion density (PepCB) as a stealth material for therapeutics. Neither tissue histological changes in liver, kidney, or spleen, nor abnormal behavior, sickness or death was induced by the synthesized polymer after high‐dosage administration for three months in rats. When conjugated to a therapeutic protein uricase, the uricase–PepCB bioconjugate showed significantly improved pharmacokinetics and immunological properties compared with uricase–PEG conjugates." @default.
- W2801703535 created "2018-05-17" @default.
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- W2801703535 date "2018-05-24" @default.
- W2801703535 modified "2023-10-06" @default.
- W2801703535 title "Polypeptides with High Zwitterion Density for Safe and Effective Therapeutics" @default.
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- W2801703535 doi "https://doi.org/10.1002/anie.201802452" @default.
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