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• W2801707590 endingPage "1148" @default.
• W2801707590 startingPage "1135" @default.
• W2801707590 abstract "Mammalian oogenesis and folliculogenesis share a dynamic connection that is critical for gamete development. For maintenance of quiescence or follicular activation, follicles must respond to soluble signals (growth factors and hormones) and physical stresses, including mechanical forces and osmotic shifts. Likewise, mechanical processes are involved in cortical tension and cell polarity in oocytes. Our objective was to examine the contribution and influence of biomechanical signaling in female mammalian gametogenesis. We performed a systematic review to assess and summarize the effects of mechanical signaling and mechanotransduction in oocyte maturation and folliculogenesis and to explore possible clinical applications. The review identified 2568 publications of which 122 met the inclusion criteria. The integration of mechanical and cell signaling pathways in gametogenesis is complex. Follicular activation or quiescence are influenced by mechanical signaling through the Hippo and Akt pathways involving the yes-associated protein (YAP), transcriptional coactivator with PDZ-binding motif (TAZ), phosphatase and tensin homolog deleted from chromosome 10 (PTEN) gene, the mammalian target of rapamycin (mTOR), and forkhead box O3 (FOXO3) gene. There is overwhelming evidence that mechanical signaling plays a crucial role in development of the ovary, follicle, and oocyte throughout gametogenesis. Emerging data suggest the complexities of mechanotransduction and the biomechanics of oocytes and follicles are integral to understanding of primary ovarian insufficiency, ovarian aging, polycystic ovary syndrome, and applications of fertility preservation." @default.
• W2801707590 created "2018-05-17" @default.
• W2801707590 creator A5016148637 @default.
• W2801707590 creator A5016627090 @default.
• W2801707590 creator A5024977438 @default.
• W2801707590 creator A5026319425 @default.
• W2801707590 creator A5034659968 @default.
• W2801707590 creator A5035863014 @default.
• W2801707590 date "2018-04-24" @default.
• W2801707590 modified "2023-10-13" @default.
• W2801707590 title "Biomechanics and mechanical signaling in the ovary: a systematic review" @default.
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