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- W2801709914 abstract "Background Alefacept was the first biologic therapy approved for the treatment of chronic plaque psoriasis in Canada. Objective The AWARE study was an observational phase IV study whose main goal was to describe the outcomes of alefacept treatment in a broad population of Canadian psoriasis patients. Methods A total of 426 patients with chronic plaque psoriasis were enrolled from 37 clinics across Canada. Patients were treated with up to two courses of alefacept and followed for up to 60 weeks. Results The majority of patients had a moderate to marked response to alefacept treatment. Treatment with concomitant systemic therapy was discontinued or reduced in up to a third of subjects. Forty percent completed the entire follow-up period without receiving a second course of alefacept. Conclusion In routine clinical settings in Canada, alefacept is an effective and safe option for the treatment of a wide range of patients with psoriasis." @default.
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- W2801709914 date "2009-12-01" @default.
- W2801709914 modified "2023-09-23" @default.
- W2801709914 title "Clinical Experience with Alefacept in Canadian Patients with Psoriasis: The Amevive Wisdom Acquired from Real-world Evidence (AWARE) Study" @default.
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- W2801709914 doi "https://doi.org/10.1177/247553030915a00201" @default.
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