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- W2801733864 endingPage "6963" @default.
- W2801733864 startingPage "6945" @default.
- W2801733864 abstract "Target identification is a high-priority, albeit challenging, aspect of drug discovery. Diazirine-based photoaffinity probes (PAPs) can facilitate the process by covalently capturing transient molecular interactions. This can help identify target proteins and map the ligand’s interactome. Diazirine probes have even been incorporated by cellular machinery into proteins. Embarking on the synthesis of customized PAPs, containing either an aliphatic or trifluoromethyl phenyl diazirine, can be a considerable endeavor, particularly for medicinal chemists and chemical biologists new to the field. This review takes a synthetic focus, aiming to summarize available routes, propose new avenues, and illuminate recent advances in diazirine synthesis. Select examples of diazirine photoaffinity labeling applications have been included throughout to provide instructive definition of the advantages and limitations of the technology while simultaneously highlighting how these reagents can be applied in a practical sense." @default.
- W2801733864 created "2018-05-17" @default.
- W2801733864 creator A5016383642 @default.
- W2801733864 creator A5072344236 @default.
- W2801733864 date "2018-04-23" @default.
- W2801733864 modified "2023-10-17" @default.
- W2801733864 title "Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis" @default.
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