FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801751486> ?p ?o ?g. }

• W2801751486 endingPage "29" @default.
• W2801751486 startingPage "19" @default.
• W2801751486 abstract "Ultraviolet B (UVB) irradiation exerts multiple effects on skin cells, inducing apoptosis, senescence and carcinogenesis. Toll-like receptor 3, a member of pattern recognition receptors, is reported to initiate inflammation by recognizing double-strand RNA (dsRNA) released from UVB-irradiated cells. It has not been studied, however, whether apoptosis induction in UVB irradiation is attributed to TLR3 activation. Here, we report on the pro-apoptotic role of TLR3 in UVB-irradiated epidermal cells. Poly I:C, an analogue of dsRNA that activates TLR3, was used in combination with sub-lethal UVB (4.8 mJ/cm2) irradiation for investigating the effects of TLR3 activation on human immortalized keratinocyte HaCaT cells. Although sub-lethal dose of either Poly I:C or UVB alone did not induce cell death, UVB-Poly I:C co-treatment synergistically induced cell death by activation of caspase-3 and cleavages of ICAD and PARP, with apoptotic features when stained with Annexin V/PI or Hoechst 33342. Treatment with pan-caspase inhibitor, Z-VAD, attenuated UVB-Poly I:C-induced cell death. Silencing TLR3 by siRNA rescued HaCaT cells from UVB-Poly I:C-induced apoptosis. NF-κB, a major downstream component of TLR3 pathway, that usually negatively regulates the classical TLR3 apoptotic pathway, was analyzed by western blotting and immunofluorescence confocal microscopy. The results indicate to our surprise that NF-κB is translocated to nucleus in the cells co-treated with UVB-Poly I:C. The nuclear translocation of NF-κB is attenuated by TLR3 silencing. Treatment with BAY, an inhibitor of NF-κB pathway, blocked UVB-Poly I:C-induced apoptosis. Therefore, we conclude that NF-κB pathway plays a cytotoxic role in UVB-Poly I:C-treated HaCaT cells, mediating TLR3-related apoptosis." @default.
• W2801751486 created "2018-05-17" @default.
• W2801751486 creator A5002661071 @default.
• W2801751486 creator A5022644338 @default.
• W2801751486 creator A5023509664 @default.
• W2801751486 creator A5026283201 @default.
• W2801751486 creator A5030939053 @default.
• W2801751486 creator A5036866849 @default.
• W2801751486 creator A5040648336 @default.
• W2801751486 creator A5045272575 @default.
• W2801751486 creator A5069771785 @default.
• W2801751486 creator A5091089849 @default.
• W2801751486 date "2018-07-01" @default.
• W2801751486 modified "2023-10-13" @default.
• W2801751486 title "Sub-lethal ultraviolet B irradiation and Poly I:C treatment synergistically induced apoptosis of HaCaT cells through NF-κB pathway" @default.
• W2801751486 cites W1492302205 @default.
• W2801751486 cites W1526999767 @default.
• W2801751486 cites W1534658432 @default.
• W2801751486 cites W1950305586 @default.
• W2801751486 cites W1967480197 @default.
• W2801751486 cites W1983398917 @default.
• W2801751486 cites W1986283558 @default.
• W2801751486 cites W1989326997 @default.
• W2801751486 cites W1999211065 @default.
• W2801751486 cites W2004651892 @default.
• W2801751486 cites W2005226158 @default.
• W2801751486 cites W2007648377 @default.
• W2801751486 cites W2011137696 @default.
• W2801751486 cites W2012612087 @default.
• W2801751486 cites W2015713055 @default.
• W2801751486 cites W2016153925 @default.
• W2801751486 cites W2019712119 @default.
• W2801751486 cites W2021908792 @default.
• W2801751486 cites W2029770726 @default.
• W2801751486 cites W2029913181 @default.
• W2801751486 cites W2054265941 @default.
• W2801751486 cites W2054273226 @default.
• W2801751486 cites W2061185732 @default.
• W2801751486 cites W2061275827 @default.
• W2801751486 cites W2062690848 @default.
• W2801751486 cites W2067404285 @default.
• W2801751486 cites W2070131223 @default.
• W2801751486 cites W2076361525 @default.
• W2801751486 cites W2077246535 @default.
• W2801751486 cites W2082821194 @default.
• W2801751486 cites W2090900728 @default.
• W2801751486 cites W2104123741 @default.
• W2801751486 cites W2110871272 @default.
• W2801751486 cites W2111867452 @default.
• W2801751486 cites W2116508133 @default.
• W2801751486 cites W2138876537 @default.
• W2801751486 cites W2141639846 @default.
• W2801751486 cites W2142471137 @default.
• W2801751486 cites W2142982089 @default.
• W2801751486 cites W2146915650 @default.
• W2801751486 cites W2170554156 @default.
• W2801751486 cites W2525263787 @default.
• W2801751486 cites W2550910239 @default.
• W2801751486 cites W2583893291 @default.
• W2801751486 cites W2592580264 @default.
• W2801751486 cites W2593765454 @default.
• W2801751486 cites W2608614623 @default.
• W2801751486 cites W2999065750 @default.
• W2801751486 cites W4379365691 @default.
• W2801751486 doi "https://doi.org/10.1016/j.molimm.2018.04.001" @default.
• W2801751486 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29674236" @default.
• W2801751486 hasPublicationYear "2018" @default.
• W2801751486 type Work @default.
• W2801751486 sameAs 2801751486 @default.
• W2801751486 citedByCount "9" @default.
• W2801751486 countsByYear W28017514862018 @default.
• W2801751486 countsByYear W28017514862019 @default.
• W2801751486 countsByYear W28017514862020 @default.
• W2801751486 countsByYear W28017514862021 @default.
• W2801751486 countsByYear W28017514862022 @default.
• W2801751486 countsByYear W28017514862023 @default.
• W2801751486 crossrefType "journal-article" @default.
• W2801751486 hasAuthorship W2801751486A5002661071 @default.
• W2801751486 hasAuthorship W2801751486A5022644338 @default.
• W2801751486 hasAuthorship W2801751486A5023509664 @default.
• W2801751486 hasAuthorship W2801751486A5026283201 @default.
• W2801751486 hasAuthorship W2801751486A5030939053 @default.
• W2801751486 hasAuthorship W2801751486A5036866849 @default.
• W2801751486 hasAuthorship W2801751486A5040648336 @default.
• W2801751486 hasAuthorship W2801751486A5045272575 @default.
• W2801751486 hasAuthorship W2801751486A5069771785 @default.
• W2801751486 hasAuthorship W2801751486A5091089849 @default.
• W2801751486 hasConcept C118995209 @default.
• W2801751486 hasConcept C153911025 @default.
• W2801751486 hasConcept C185592680 @default.
• W2801751486 hasConcept C190283241 @default.
• W2801751486 hasConcept C2777074287 @default.
• W2801751486 hasConcept C31573885 @default.
• W2801751486 hasConcept C502942594 @default.
• W2801751486 hasConcept C54355233 @default.
• W2801751486 hasConcept C55493867 @default.
• W2801751486 hasConcept C56483683 @default.
• W2801751486 hasConcept C66008609 @default.

• next