Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801753207> ?p ?o ?g. }
- W2801753207 endingPage "39" @default.
- W2801753207 startingPage "25" @default.
- W2801753207 abstract "Objective Vedolizumab, a monoclonal antibody directed against the integrin heterodimer α4β7, is approved for the treatment of Crohn’s disease and ulcerative colitis. The efficacy of vedolizumab has been suggested to result from inhibition of intestinal T cell trafficking although human data to support this conclusion are scarce. We therefore performed a comprehensive analysis of vedolizumab-induced alterations in mucosal and systemic immunity in patients with inflammatory bowel disease (IBD), using anti-inflammatory therapy with the TNFα antibody infliximab as control. Design Immunophenotyping, immunohistochemistry, T cell receptor profiling and RNA sequencing were performed using blood and colonic biopsies from patients with IBD before and during treatment with vedolizumab (n=18) or, as control, the anti-TNFα antibody infliximab (n=20). Leucocyte trafficking in vivo was assessed using single photon emission computed tomography and endomicroscopy. Results Vedolizumab was not associated with alterations in the abundance or phenotype of lamina propria T cells and did not affect the mucosal T cell repertoire or leucocyte trafficking in vivo. Surprisingly, however, α4β7 antibody treatment was associated with substantial effects on innate immunity including changes in macrophage populations and pronounced alterations in the expression of molecules involved in microbial sensing, chemoattraction and regulation of the innate effector response. These effects were specific to vedolizumab, not observed in response to the TNFα antibody infliximab, and associated with inhibition of intestinal inflammation. Conclusion Our findings suggest that modulation of innate immunity contributes to the therapeutic efficacy of vedolizumab in IBD. Trial registration number NCT02694588" @default.
- W2801753207 created "2018-05-17" @default.
- W2801753207 creator A5013938574 @default.
- W2801753207 creator A5016302235 @default.
- W2801753207 creator A5018997928 @default.
- W2801753207 creator A5019146039 @default.
- W2801753207 creator A5020447473 @default.
- W2801753207 creator A5025154287 @default.
- W2801753207 creator A5028715038 @default.
- W2801753207 creator A5029695924 @default.
- W2801753207 creator A5031900006 @default.
- W2801753207 creator A5032167124 @default.
- W2801753207 creator A5037319945 @default.
- W2801753207 creator A5038565796 @default.
- W2801753207 creator A5041624832 @default.
- W2801753207 creator A5044651811 @default.
- W2801753207 creator A5048738279 @default.
- W2801753207 creator A5049829923 @default.
- W2801753207 creator A5053916370 @default.
- W2801753207 creator A5054564152 @default.
- W2801753207 creator A5059435501 @default.
- W2801753207 creator A5065349221 @default.
- W2801753207 creator A5070802204 @default.
- W2801753207 creator A5072584736 @default.
- W2801753207 creator A5073345578 @default.
- W2801753207 creator A5076952709 @default.
- W2801753207 creator A5078373740 @default.
- W2801753207 date "2018-05-05" @default.
- W2801753207 modified "2023-10-15" @default.
- W2801753207 title "Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease" @default.
- W2801753207 cites W1420615028 @default.
- W2801753207 cites W1506890399 @default.
- W2801753207 cites W1524470153 @default.
- W2801753207 cites W1575253744 @default.
- W2801753207 cites W1619160309 @default.
- W2801753207 cites W1916911965 @default.
- W2801753207 cites W1922746363 @default.
- W2801753207 cites W1944355477 @default.
- W2801753207 cites W1960383875 @default.
- W2801753207 cites W1968818081 @default.
- W2801753207 cites W1972561581 @default.
- W2801753207 cites W1978391087 @default.
- W2801753207 cites W1985987855 @default.
- W2801753207 cites W1986834440 @default.
- W2801753207 cites W1991865241 @default.
- W2801753207 cites W1992979350 @default.
- W2801753207 cites W1998917330 @default.
- W2801753207 cites W1999427807 @default.
- W2801753207 cites W2004950298 @default.
- W2801753207 cites W2015837052 @default.
- W2801753207 cites W2029943272 @default.
- W2801753207 cites W2036897871 @default.
- W2801753207 cites W2041677964 @default.
- W2801753207 cites W2046643310 @default.
- W2801753207 cites W2047977785 @default.
- W2801753207 cites W2049017883 @default.
- W2801753207 cites W2051241958 @default.
- W2801753207 cites W2051641513 @default.
- W2801753207 cites W2073121745 @default.
- W2801753207 cites W2077531651 @default.
- W2801753207 cites W2077820846 @default.
- W2801753207 cites W2089041106 @default.
- W2801753207 cites W2100305481 @default.
- W2801753207 cites W2102116540 @default.
- W2801753207 cites W2116452864 @default.
- W2801753207 cites W2121116119 @default.
- W2801753207 cites W2123307454 @default.
- W2801753207 cites W2127589768 @default.
- W2801753207 cites W2132602555 @default.
- W2801753207 cites W2133723438 @default.
- W2801753207 cites W2133755989 @default.
- W2801753207 cites W2134526812 @default.
- W2801753207 cites W2137935903 @default.
- W2801753207 cites W2148014542 @default.
- W2801753207 cites W2152239989 @default.
- W2801753207 cites W2156372979 @default.
- W2801753207 cites W2160619682 @default.
- W2801753207 cites W2162805528 @default.
- W2801753207 cites W2163250554 @default.
- W2801753207 cites W2166171121 @default.
- W2801753207 cites W2167225983 @default.
- W2801753207 cites W2185265351 @default.
- W2801753207 cites W2317739826 @default.
- W2801753207 cites W2343155348 @default.
- W2801753207 cites W2405201977 @default.
- W2801753207 cites W2515435336 @default.
- W2801753207 cites W2520997567 @default.
- W2801753207 cites W2578885448 @default.
- W2801753207 cites W2607887360 @default.
- W2801753207 cites W2774927467 @default.
- W2801753207 doi "https://doi.org/10.1136/gutjnl-2018-316023" @default.
- W2801753207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29730603" @default.
- W2801753207 hasPublicationYear "2018" @default.
- W2801753207 type Work @default.
- W2801753207 sameAs 2801753207 @default.
- W2801753207 citedByCount "150" @default.
- W2801753207 countsByYear W28017532072018 @default.
- W2801753207 countsByYear W28017532072019 @default.