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- W2801778046 endingPage "1658" @default.
- W2801778046 startingPage "1644" @default.
- W2801778046 abstract "The delicate balance of excitation and inhibition is crucial for proper function of the cerebral cortex, relying on the accurate number and subtype composition of inhibitory gamma-aminobutyric (GABA)-expressing interneurons. Various intrinsic and extrinsic factors precisely orchestrate their multifaceted development including the long-range migration from the basal telencephalon to cortical targets as well as interneuron survival throughout the developmental period. Particularly expressed guidance receptors were described to channel the migration of cortical interneurons deriving from the medial ganglionic eminence (MGE) and the preoptic area (POA) along distinct routes. Hence, unveiling the regulatory genetic networks controlling subtype-specific gene expression profiles is key to understand interneuron-specific developmental programs and to reveal causes for associated disorders. In contrast to MGE-derived interneurons, little is known about the transcriptional networks in interneurons born in the POA. Here, we provide first evidence for the LIM-homeobox transcription factor LHX1 as a crucial key player in the post-mitotic development of POA-derived cortical interneurons. By transcriptional regulation of related genes, LHX1 modulates their survival as well as the subtype-specific expression of guidance receptors of the Eph/ephrin family, thereby affecting directional migration and layer distribution in the adult cortex." @default.
- W2801778046 created "2018-05-17" @default.
- W2801778046 creator A5046984040 @default.
- W2801778046 creator A5078537639 @default.
- W2801778046 creator A5086916307 @default.
- W2801778046 creator A5089027708 @default.
- W2801778046 date "2018-04-18" @default.
- W2801778046 modified "2023-09-26" @default.
- W2801778046 title "The Transcription Factor LHX1 Regulates the Survival and Directed Migration of POA-derived Cortical Interneurons" @default.
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