Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801782593> ?p ?o ?g. }
- W2801782593 endingPage "566" @default.
- W2801782593 startingPage "559" @default.
- W2801782593 abstract "Delta sleep-inducing peptide (DSIP) is an endogenous peptide that is constantly present in several different brain regions. Lindane is used as a pesticide and scabicide, but it also induces seizures refractory to conventional antiepileptics. The aim of this paper was to determine whether DSIP modulates lindane-induced seizures in rats in a behavioral and electroencephalographic (EEG) study. DSIP (1 mg/kg, i.p.) or dimethyl-sulfoxide (DMSO, 0.5 ml/kg, intraperitoneally (i.p.)) were injected 30 min before lindane (8 mg/kg, i.p.) to adult male rats with previously implanted electrodes for EEG registration. During the following 30 min, the EEG was registered, and the following behavioral characteristics of seizures were observed: incidence, latency and intensity. A descriptive scale with grades from 0 to 4 provided an estimate of seizure intensity. In the EEG, the number and duration of ictal periods were analyzed using NeuroSciLaBG (Belgrade, Serbia) software. The lethality rate was also analyzed. DSIP-treated animals showed significantly modified characteristics of lindane-induced seizures when compared to the group without DSIP pretreatment (i.e. a reduced seizure intensity and a prolonged seizure latency period). However, no significant effects of DSIP on seizure incidence and lindane-induced lethality were observed. EEG analyses showed a significantly decreased number of lindane-induced EEG ictal periods in DSIP-treated animals, but with unaltered duration. These results show that DSIP favorably modulates lindane-induced seizures in rats, showing a potential to be an adjuvant component of antiepileptic treatment strategy for refractory seizures." @default.
- W2801782593 created "2018-05-17" @default.
- W2801782593 creator A5011036899 @default.
- W2801782593 creator A5020479432 @default.
- W2801782593 creator A5033530059 @default.
- W2801782593 creator A5049485419 @default.
- W2801782593 creator A5055850229 @default.
- W2801782593 creator A5068812589 @default.
- W2801782593 date "2018-01-01" @default.
- W2801782593 modified "2023-10-18" @default.
- W2801782593 title "Modulatory effects of delta sleep-inducing peptide in a lindane model of generalized seizures" @default.
- W2801782593 cites W11317200 @default.
- W2801782593 cites W130882510 @default.
- W2801782593 cites W1527468221 @default.
- W2801782593 cites W1963728255 @default.
- W2801782593 cites W1963980166 @default.
- W2801782593 cites W1969109023 @default.
- W2801782593 cites W1971690245 @default.
- W2801782593 cites W1982394694 @default.
- W2801782593 cites W1982601240 @default.
- W2801782593 cites W1987549932 @default.
- W2801782593 cites W2006497495 @default.
- W2801782593 cites W2007335498 @default.
- W2801782593 cites W2014408954 @default.
- W2801782593 cites W2016468819 @default.
- W2801782593 cites W2031859852 @default.
- W2801782593 cites W2044329441 @default.
- W2801782593 cites W2050287406 @default.
- W2801782593 cites W2058141568 @default.
- W2801782593 cites W2059151919 @default.
- W2801782593 cites W2061099214 @default.
- W2801782593 cites W2062895901 @default.
- W2801782593 cites W2063700947 @default.
- W2801782593 cites W2063866872 @default.
- W2801782593 cites W2064424979 @default.
- W2801782593 cites W2067494085 @default.
- W2801782593 cites W2075556621 @default.
- W2801782593 cites W2075746290 @default.
- W2801782593 cites W2090129297 @default.
- W2801782593 cites W2091355595 @default.
- W2801782593 cites W2110764396 @default.
- W2801782593 cites W2144365512 @default.
- W2801782593 cites W2162962792 @default.
- W2801782593 cites W2330180135 @default.
- W2801782593 cites W2346124662 @default.
- W2801782593 cites W2403311904 @default.
- W2801782593 cites W2412060564 @default.
- W2801782593 cites W2412171449 @default.
- W2801782593 cites W2754015035 @default.
- W2801782593 cites W638873531 @default.
- W2801782593 cites W99098873 @default.
- W2801782593 cites W2415092049 @default.
- W2801782593 doi "https://doi.org/10.2298/abs180109017h" @default.
- W2801782593 hasPublicationYear "2018" @default.
- W2801782593 type Work @default.
- W2801782593 sameAs 2801782593 @default.
- W2801782593 citedByCount "1" @default.
- W2801782593 countsByYear W28017825932023 @default.
- W2801782593 crossrefType "journal-article" @default.
- W2801782593 hasAuthorship W2801782593A5011036899 @default.
- W2801782593 hasAuthorship W2801782593A5020479432 @default.
- W2801782593 hasAuthorship W2801782593A5033530059 @default.
- W2801782593 hasAuthorship W2801782593A5049485419 @default.
- W2801782593 hasAuthorship W2801782593A5055850229 @default.
- W2801782593 hasAuthorship W2801782593A5068812589 @default.
- W2801782593 hasBestOaLocation W28017825931 @default.
- W2801782593 hasConcept C126322002 @default.
- W2801782593 hasConcept C15744967 @default.
- W2801782593 hasConcept C161176658 @default.
- W2801782593 hasConcept C169760540 @default.
- W2801782593 hasConcept C17755696 @default.
- W2801782593 hasConcept C185592680 @default.
- W2801782593 hasConcept C2778186239 @default.
- W2801782593 hasConcept C2780120631 @default.
- W2801782593 hasConcept C42219234 @default.
- W2801782593 hasConcept C522805319 @default.
- W2801782593 hasConcept C6557445 @default.
- W2801782593 hasConcept C71924100 @default.
- W2801782593 hasConcept C86803240 @default.
- W2801782593 hasConceptScore W2801782593C126322002 @default.
- W2801782593 hasConceptScore W2801782593C15744967 @default.
- W2801782593 hasConceptScore W2801782593C161176658 @default.
- W2801782593 hasConceptScore W2801782593C169760540 @default.
- W2801782593 hasConceptScore W2801782593C17755696 @default.
- W2801782593 hasConceptScore W2801782593C185592680 @default.
- W2801782593 hasConceptScore W2801782593C2778186239 @default.
- W2801782593 hasConceptScore W2801782593C2780120631 @default.
- W2801782593 hasConceptScore W2801782593C42219234 @default.
- W2801782593 hasConceptScore W2801782593C522805319 @default.
- W2801782593 hasConceptScore W2801782593C6557445 @default.
- W2801782593 hasConceptScore W2801782593C71924100 @default.
- W2801782593 hasConceptScore W2801782593C86803240 @default.
- W2801782593 hasFunder F4320322729 @default.
- W2801782593 hasIssue "3" @default.
- W2801782593 hasLocation W28017825931 @default.
- W2801782593 hasOpenAccess W2801782593 @default.
- W2801782593 hasPrimaryLocation W28017825931 @default.
- W2801782593 hasRelatedWork W2008631356 @default.