FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801786723> ?p ?o ?g. }

• W2801786723 endingPage "258" @default.
• W2801786723 startingPage "249" @default.
• W2801786723 abstract "This study aims to investigate factors affecting weakly basic drugs liposomal systems. Resolution V fractional factorial design (2V5−1) is used as an example of screening designs that would better be used as a wise step before proceeding with detailed factors effects or optimization studies. Five factors probable to affect liposomal systems of weakly basic drugs were investigated using Amisulpride as a model drug. Factors studied were; A: Preparation technique B: Phosphatidyl choline (PhC) amount (mg) C: Cholesterol: PhC molar ratio, D: Hydration volume (ml) and E: Sonication type. Levels investigated were; Ammonium sulphate-pH gradient technique or Transmembrane zinc chelation-pH gradient technique, 200 or 400 mg, 0 or 0.5, 10 or 20 ml and bath or probe sonication for A, B, C, D and E respectively. Responses measured were Particle size (PS) (nm), Zeta potential (ZP) (mV) and Entrapment efficiency percent (EE%). Ion selective electrode was used as a novel method for measuring unentrapped drug concentration and calculating entrapment efficiency without the need for liposomal separation. Factors mainly affecting the studied responses were Cholesterol: PhC ratio and hydration volume for PS, preparation technique for ZP and preparation technique and hydration volume for EE%. The applied 2V5−1 design enabled the use of only 16 trial combinations for screening the influence of five factors on weakly basic drugs liposomal systems. This clarifies the value of the use of screening experiments before extensive investigation of certain factors in detailed optimization studies." @default.
• W2801786723 created "2018-05-17" @default.
• W2801786723 creator A5011090692 @default.
• W2801786723 creator A5035776595 @default.
• W2801786723 creator A5085260941 @default.
• W2801786723 date "2018-07-01" @default.
• W2801786723 modified "2023-09-28" @default.
• W2801786723 title "Resolution V fractional factorial design for screening of factors affecting weakly basic drugs liposomal systems" @default.
• W2801786723 cites W1498020422 @default.
• W2801786723 cites W1967974277 @default.
• W2801786723 cites W1973752567 @default.
• W2801786723 cites W1977153597 @default.
• W2801786723 cites W1977211805 @default.
• W2801786723 cites W1977559238 @default.
• W2801786723 cites W1989868678 @default.
• W2801786723 cites W1998291237 @default.
• W2801786723 cites W2015930349 @default.
• W2801786723 cites W2031393058 @default.
• W2801786723 cites W2033291900 @default.
• W2801786723 cites W2036944284 @default.
• W2801786723 cites W2040226141 @default.
• W2801786723 cites W2044618645 @default.
• W2801786723 cites W2045296265 @default.
• W2801786723 cites W2047630076 @default.
• W2801786723 cites W2062708441 @default.
• W2801786723 cites W2062874552 @default.
• W2801786723 cites W2067149550 @default.
• W2801786723 cites W2071773769 @default.
• W2801786723 cites W2074131229 @default.
• W2801786723 cites W2075078368 @default.
• W2801786723 cites W2082093933 @default.
• W2801786723 cites W2082997632 @default.
• W2801786723 cites W2083492332 @default.
• W2801786723 cites W2106095037 @default.
• W2801786723 cites W2120694339 @default.
• W2801786723 cites W2142471033 @default.
• W2801786723 cites W2144589574 @default.
• W2801786723 cites W2144901738 @default.
• W2801786723 cites W2149744058 @default.
• W2801786723 cites W2328633968 @default.
• W2801786723 cites W2330330235 @default.
• W2801786723 cites W2343131986 @default.
• W2801786723 cites W2606003614 @default.
• W2801786723 cites W2613052595 @default.
• W2801786723 cites W2794135364 @default.
• W2801786723 cites W4246209615 @default.
• W2801786723 cites W2141515691 @default.
• W2801786723 doi "https://doi.org/10.1016/j.ejps.2018.04.028" @default.
• W2801786723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29689287" @default.
• W2801786723 hasPublicationYear "2018" @default.
• W2801786723 type Work @default.
• W2801786723 sameAs 2801786723 @default.
• W2801786723 citedByCount "15" @default.
• W2801786723 countsByYear W28017867232019 @default.
• W2801786723 countsByYear W28017867232020 @default.
• W2801786723 countsByYear W28017867232021 @default.
• W2801786723 countsByYear W28017867232022 @default.
• W2801786723 crossrefType "journal-article" @default.
• W2801786723 hasAuthorship W2801786723A5011090692 @default.
• W2801786723 hasAuthorship W2801786723A5035776595 @default.
• W2801786723 hasAuthorship W2801786723A5085260941 @default.
• W2801786723 hasConcept C104628117 @default.
• W2801786723 hasConcept C105795698 @default.
• W2801786723 hasConcept C138268822 @default.
• W2801786723 hasConcept C154945302 @default.
• W2801786723 hasConcept C155672457 @default.
• W2801786723 hasConcept C16469947 @default.
• W2801786723 hasConcept C169222746 @default.
• W2801786723 hasConcept C171250308 @default.
• W2801786723 hasConcept C185154212 @default.
• W2801786723 hasConcept C185592680 @default.
• W2801786723 hasConcept C192562407 @default.
• W2801786723 hasConcept C33923547 @default.
• W2801786723 hasConcept C41008148 @default.
• W2801786723 hasConcept C43617362 @default.
• W2801786723 hasConcept C55493867 @default.
• W2801786723 hasConcept C86181022 @default.
• W2801786723 hasConceptScore W2801786723C104628117 @default.
• W2801786723 hasConceptScore W2801786723C105795698 @default.
• W2801786723 hasConceptScore W2801786723C138268822 @default.
• W2801786723 hasConceptScore W2801786723C154945302 @default.
• W2801786723 hasConceptScore W2801786723C155672457 @default.
• W2801786723 hasConceptScore W2801786723C16469947 @default.
• W2801786723 hasConceptScore W2801786723C169222746 @default.
• W2801786723 hasConceptScore W2801786723C171250308 @default.
• W2801786723 hasConceptScore W2801786723C185154212 @default.
• W2801786723 hasConceptScore W2801786723C185592680 @default.
• W2801786723 hasConceptScore W2801786723C192562407 @default.
• W2801786723 hasConceptScore W2801786723C33923547 @default.
• W2801786723 hasConceptScore W2801786723C41008148 @default.
• W2801786723 hasConceptScore W2801786723C43617362 @default.
• W2801786723 hasConceptScore W2801786723C55493867 @default.
• W2801786723 hasConceptScore W2801786723C86181022 @default.
• W2801786723 hasLocation W28017867231 @default.
• W2801786723 hasLocation W28017867232 @default.
• W2801786723 hasOpenAccess W2801786723 @default.
• W2801786723 hasPrimaryLocation W28017867231 @default.
• W2801786723 hasRelatedWork W1496888151 @default.

• next