Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801787974> ?p ?o ?g. }
- W2801787974 endingPage "2625" @default.
- W2801787974 startingPage "2613" @default.
- W2801787974 abstract "Critical immune-suppressive pathways beyond programmed death 1 (PD-1) and programmed death ligand 1 (PD-L1) require greater attention. Nectins and nectin-like molecules might be promising targets for immunotherapy, since they play critical roles in cell proliferation and migration and exert immunomodulatory functions in pathophysiological conditions. Here, we show CD155 expression in both malignant cells and tumor-infiltrating myeloid cells in humans and mice. Cd155–/– mice displayed reduced tumor growth and metastasis via DNAM-1 upregulation and enhanced effector function of CD8+ T and NK cells, respectively. CD155-deleted tumor cells also displayed slower tumor growth and reduced metastases, demonstrating the importance of a tumor-intrinsic role of CD155. CD155 absence on host and tumor cells exerted an even greater inhibition of tumor growth and metastasis. Blockade of PD-1 or both PD-1 and CTLA4 was more effective in settings in which CD155 was limiting, suggesting the clinical potential of cotargeting PD-L1 and CD155 function." @default.
- W2801787974 created "2018-05-17" @default.
- W2801787974 creator A5007330428 @default.
- W2801787974 creator A5008563915 @default.
- W2801787974 creator A5009957181 @default.
- W2801787974 creator A5017167748 @default.
- W2801787974 creator A5020855075 @default.
- W2801787974 creator A5025785991 @default.
- W2801787974 creator A5035282947 @default.
- W2801787974 creator A5044848608 @default.
- W2801787974 creator A5055821828 @default.
- W2801787974 creator A5059522957 @default.
- W2801787974 creator A5061575707 @default.
- W2801787974 creator A5072077716 @default.
- W2801787974 creator A5074513079 @default.
- W2801787974 creator A5077460838 @default.
- W2801787974 creator A5078238655 @default.
- W2801787974 creator A5084825146 @default.
- W2801787974 creator A5085524872 @default.
- W2801787974 date "2018-05-14" @default.
- W2801787974 modified "2023-09-25" @default.
- W2801787974 title "CD155 loss enhances tumor suppression via combined host and tumor-intrinsic mechanisms" @default.
- W2801787974 cites W118632756 @default.
- W2801787974 cites W1552754679 @default.
- W2801787974 cites W1787595709 @default.
- W2801787974 cites W1863751964 @default.
- W2801787974 cites W1889335134 @default.
- W2801787974 cites W1972472884 @default.
- W2801787974 cites W1981352048 @default.
- W2801787974 cites W1983812780 @default.
- W2801787974 cites W1987165863 @default.
- W2801787974 cites W1998235510 @default.
- W2801787974 cites W2001509426 @default.
- W2801787974 cites W2004191344 @default.
- W2801787974 cites W2022072812 @default.
- W2801787974 cites W2022959807 @default.
- W2801787974 cites W2023283620 @default.
- W2801787974 cites W2026488678 @default.
- W2801787974 cites W2029399624 @default.
- W2801787974 cites W2034841713 @default.
- W2801787974 cites W2039084448 @default.
- W2801787974 cites W2042037279 @default.
- W2801787974 cites W2050962105 @default.
- W2801787974 cites W2069773259 @default.
- W2801787974 cites W2072598572 @default.
- W2801787974 cites W2073303594 @default.
- W2801787974 cites W2080942657 @default.
- W2801787974 cites W2082252308 @default.
- W2801787974 cites W2083616674 @default.
- W2801787974 cites W2092207202 @default.
- W2801787974 cites W2123635642 @default.
- W2801787974 cites W2142169541 @default.
- W2801787974 cites W2142256141 @default.
- W2801787974 cites W2166662937 @default.
- W2801787974 cites W2169810189 @default.
- W2801787974 cites W2225828937 @default.
- W2801787974 cites W2254024193 @default.
- W2801787974 cites W2282550179 @default.
- W2801787974 cites W2332535881 @default.
- W2801787974 cites W2347141054 @default.
- W2801787974 cites W2465860350 @default.
- W2801787974 cites W2520704033 @default.
- W2801787974 cites W2521503673 @default.
- W2801787974 cites W2570190993 @default.
- W2801787974 cites W2572174216 @default.
- W2801787974 cites W2590023130 @default.
- W2801787974 cites W2592785733 @default.
- W2801787974 cites W2617703495 @default.
- W2801787974 cites W2737469573 @default.
- W2801787974 cites W2740980780 @default.
- W2801787974 cites W2741163567 @default.
- W2801787974 doi "https://doi.org/10.1172/jci98769" @default.
- W2801787974 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5983325" @default.
- W2801787974 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29757192" @default.
- W2801787974 hasPublicationYear "2018" @default.
- W2801787974 type Work @default.
- W2801787974 sameAs 2801787974 @default.
- W2801787974 citedByCount "89" @default.
- W2801787974 countsByYear W28017879742018 @default.
- W2801787974 countsByYear W28017879742019 @default.
- W2801787974 countsByYear W28017879742020 @default.
- W2801787974 countsByYear W28017879742021 @default.
- W2801787974 countsByYear W28017879742022 @default.
- W2801787974 countsByYear W28017879742023 @default.
- W2801787974 crossrefType "journal-article" @default.
- W2801787974 hasAuthorship W2801787974A5007330428 @default.
- W2801787974 hasAuthorship W2801787974A5008563915 @default.
- W2801787974 hasAuthorship W2801787974A5009957181 @default.
- W2801787974 hasAuthorship W2801787974A5017167748 @default.
- W2801787974 hasAuthorship W2801787974A5020855075 @default.
- W2801787974 hasAuthorship W2801787974A5025785991 @default.
- W2801787974 hasAuthorship W2801787974A5035282947 @default.
- W2801787974 hasAuthorship W2801787974A5044848608 @default.
- W2801787974 hasAuthorship W2801787974A5055821828 @default.
- W2801787974 hasAuthorship W2801787974A5059522957 @default.
- W2801787974 hasAuthorship W2801787974A5061575707 @default.
- W2801787974 hasAuthorship W2801787974A5072077716 @default.
- W2801787974 hasAuthorship W2801787974A5074513079 @default.