Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801793721> ?p ?o ?g. }
- W2801793721 startingPage "218545" @default.
- W2801793721 abstract "TH17 cells exhibit great heterogeneity and variable functional states in vivo. However, metabolic reprogramming of TH17 cells in vivo and its regulation during autoimmunity and host defence is unknown. Here we report that TH17 cells derived in vivo show discrete metabolic states. Metabolic states of TH17 cells in vivo were controlled at the epigenetic level, with conserved regulatory region of key metabolic regulators show distinct chromatin accessibility as demonstrated by chromatin landscape profiling. TGF-β1 signaling was further shown to be crucial for remodeling of TH17 cell chromatin states, Ahr and miR-21 were identified as essential metabolic regulators for TH17 cells. Understanding metabolic reprogramming of TH17 cells in vivo may therefore provide more defined therapeutic intervention to TH17 cell mediated autoimmune diseases and insights into TH17 cell mediated host defence." @default.
- W2801793721 created "2018-05-17" @default.
- W2801793721 creator A5000269595 @default.
- W2801793721 creator A5001030035 @default.
- W2801793721 creator A5003642180 @default.
- W2801793721 creator A5005549879 @default.
- W2801793721 creator A5008880978 @default.
- W2801793721 creator A5012278873 @default.
- W2801793721 creator A5012478380 @default.
- W2801793721 creator A5017801656 @default.
- W2801793721 creator A5027545362 @default.
- W2801793721 creator A5031936012 @default.
- W2801793721 creator A5041934647 @default.
- W2801793721 creator A5044524874 @default.
- W2801793721 creator A5053308237 @default.
- W2801793721 creator A5054169361 @default.
- W2801793721 creator A5080578507 @default.
- W2801793721 creator A5081368254 @default.
- W2801793721 creator A5090274625 @default.
- W2801793721 date "2018-05-14" @default.
- W2801793721 modified "2023-09-22" @default.
- W2801793721 title "TGF-β1 signaling remodels TH17 cell chromatin architecture for metabolic reprogramming" @default.
- W2801793721 cites W1964094843 @default.
- W2801793721 cites W1966226308 @default.
- W2801793721 cites W1995468432 @default.
- W2801793721 cites W2002809074 @default.
- W2801793721 cites W2010463731 @default.
- W2801793721 cites W2030826363 @default.
- W2801793721 cites W2036922744 @default.
- W2801793721 cites W2063441242 @default.
- W2801793721 cites W2075728036 @default.
- W2801793721 cites W2078657796 @default.
- W2801793721 cites W2079570889 @default.
- W2801793721 cites W2079999658 @default.
- W2801793721 cites W2100039832 @default.
- W2801793721 cites W2102901373 @default.
- W2801793721 cites W2103600875 @default.
- W2801793721 cites W2107369528 @default.
- W2801793721 cites W2111731663 @default.
- W2801793721 cites W2116676186 @default.
- W2801793721 cites W2117757143 @default.
- W2801793721 cites W2118455790 @default.
- W2801793721 cites W2135518377 @default.
- W2801793721 cites W2139250592 @default.
- W2801793721 cites W2158217645 @default.
- W2801793721 cites W2160551785 @default.
- W2801793721 cites W2162873738 @default.
- W2801793721 cites W2170688212 @default.
- W2801793721 cites W2209349785 @default.
- W2801793721 cites W2237013884 @default.
- W2801793721 cites W2260902767 @default.
- W2801793721 cites W2319053438 @default.
- W2801793721 cites W2415515169 @default.
- W2801793721 cites W2484862915 @default.
- W2801793721 cites W2531874824 @default.
- W2801793721 cites W2554471469 @default.
- W2801793721 cites W2607103422 @default.
- W2801793721 cites W2614424847 @default.
- W2801793721 cites W2616155686 @default.
- W2801793721 cites W2616875005 @default.
- W2801793721 cites W2741802290 @default.
- W2801793721 cites W2782841700 @default.
- W2801793721 hasPublicationYear "2018" @default.
- W2801793721 type Work @default.
- W2801793721 sameAs 2801793721 @default.
- W2801793721 citedByCount "0" @default.
- W2801793721 crossrefType "posted-content" @default.
- W2801793721 hasAuthorship W2801793721A5000269595 @default.
- W2801793721 hasAuthorship W2801793721A5001030035 @default.
- W2801793721 hasAuthorship W2801793721A5003642180 @default.
- W2801793721 hasAuthorship W2801793721A5005549879 @default.
- W2801793721 hasAuthorship W2801793721A5008880978 @default.
- W2801793721 hasAuthorship W2801793721A5012278873 @default.
- W2801793721 hasAuthorship W2801793721A5012478380 @default.
- W2801793721 hasAuthorship W2801793721A5017801656 @default.
- W2801793721 hasAuthorship W2801793721A5027545362 @default.
- W2801793721 hasAuthorship W2801793721A5031936012 @default.
- W2801793721 hasAuthorship W2801793721A5041934647 @default.
- W2801793721 hasAuthorship W2801793721A5044524874 @default.
- W2801793721 hasAuthorship W2801793721A5053308237 @default.
- W2801793721 hasAuthorship W2801793721A5054169361 @default.
- W2801793721 hasAuthorship W2801793721A5080578507 @default.
- W2801793721 hasAuthorship W2801793721A5081368254 @default.
- W2801793721 hasAuthorship W2801793721A5090274625 @default.
- W2801793721 hasBestOaLocation W28017937211 @default.
- W2801793721 hasConcept C104317684 @default.
- W2801793721 hasConcept C148738053 @default.
- W2801793721 hasConcept C1491633281 @default.
- W2801793721 hasConcept C167227067 @default.
- W2801793721 hasConcept C207001950 @default.
- W2801793721 hasConcept C41091548 @default.
- W2801793721 hasConcept C54355233 @default.
- W2801793721 hasConcept C77255625 @default.
- W2801793721 hasConcept C83640560 @default.
- W2801793721 hasConcept C86803240 @default.
- W2801793721 hasConcept C95444343 @default.
- W2801793721 hasConceptScore W2801793721C104317684 @default.
- W2801793721 hasConceptScore W2801793721C148738053 @default.
- W2801793721 hasConceptScore W2801793721C1491633281 @default.