FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801812279> ?p ?o ?g. }

• W2801812279 endingPage "3602" @default.
• W2801812279 startingPage "3585" @default.
• W2801812279 abstract "Key points Dietary Na restriction, through the mineralocorticoid aldosterone, acts on epithelial Na channels via both fast (24 h) and slow (5–7 days) mechanisms in the kidney. The fast effect entails increased proteolytic processing and trafficking of channel protein to the apical membrane. It is rapidly reversible by the mineralocorticoid receptor antagonist eplerenone and is largely lost when tubules are studied ex vivo . The slow effect does not require increased processing or surface expression, is refractory to acute eplerenone treatment, and is preserved ex vivo . Both slow and fast effects contribute to Na retention in vivo . Increased Na + reabsorption in the proximal tubule also promotes Na conservation under conditions of chronic dietary Na restriction, reducing Na + delivery to the distal nephron. Abstract Changes in the activity of the epithelial Na channel (ENaC) help to conserve extracellular fluid volume. In rats fed a low‐salt diet, proteolytic processing of ENaC increased within 1 day, and was almost maximal after 3 days. The rapid increase in the abundance of cleaved αENaC and γENaC correlated with decreased urinary Na + excretion and with increased ENaC surface expression. By contrast, ENaC activity, measured ex vivo in isolated cortical collecting ducts, increased modestly after 3 days and required 5 days to reach maximal levels. The mineralocorticoid receptor antagonist eplerenone reversed the increase in cleaved γENaC and induced natriuresis after 1 or 3 days but failed to alter either ENaC currents or Na + excretion after 7 days of Na restriction. We conclude that Na depletion, through aldosterone, stimulates ENaC via independent fast and slow mechanisms. In vivo , amiloride‐induced natriuresis increased after 1 day of Na depletion. By contrast, hydrochlorothiazide (HCTZ)‐induced natriuresis decreased gradually over 7 days, consistent with increased ability of ENaC activity to compensate for decreased Na + reabsorption in the distal convoluted tubule. Administration of amiloride and HCTZ together increased Na + excretion less in Na‐depleted compared to control animals, indicating decreased delivery of Na + to the distal nephron when dietary Na is restricted. Measurements of creatinine and Li + clearances indicated that increased Na reabsorption by the proximal tubules is responsible for the decreased delivery. Thus, Na conservation during chronic dietary salt restriction entails enhanced transport by both proximal and distal nephron segments." @default.
• W2801812279 created "2018-05-17" @default.
• W2801812279 creator A5058888558 @default.
• W2801812279 creator A5067940438 @default.
• W2801812279 creator A5075080903 @default.
• W2801812279 creator A5089954997 @default.
• W2801812279 date "2018-07-03" @default.
• W2801812279 modified "2023-09-30" @default.
• W2801812279 title "Na restriction activates epithelial Na channels in rat kidney through two mechanisms and decreases distal Na⁺delivery" @default.
• W2801812279 cites W18522112 @default.
• W2801812279 cites W1860619445 @default.
• W2801812279 cites W1954315298 @default.
• W2801812279 cites W1966102491 @default.
• W2801812279 cites W1974393761 @default.
• W2801812279 cites W1974553541 @default.
• W2801812279 cites W2005369521 @default.
• W2801812279 cites W2007210225 @default.
• W2801812279 cites W2007850369 @default.
• W2801812279 cites W2020056111 @default.
• W2801812279 cites W2049791387 @default.
• W2801812279 cites W2050220178 @default.
• W2801812279 cites W2072279008 @default.
• W2801812279 cites W2079433948 @default.
• W2801812279 cites W2087144172 @default.
• W2801812279 cites W2096483492 @default.
• W2801812279 cites W2096878801 @default.
• W2801812279 cites W2101342426 @default.
• W2801812279 cites W2102136926 @default.
• W2801812279 cites W2107566012 @default.
• W2801812279 cites W2110076415 @default.
• W2801812279 cites W2113568840 @default.
• W2801812279 cites W2123006028 @default.
• W2801812279 cites W2125003736 @default.
• W2801812279 cites W2129397773 @default.
• W2801812279 cites W2130632820 @default.
• W2801812279 cites W2136119054 @default.
• W2801812279 cites W2138550890 @default.
• W2801812279 cites W2143537048 @default.
• W2801812279 cites W2148474634 @default.
• W2801812279 cites W2169106763 @default.
• W2801812279 cites W2182592105 @default.
• W2801812279 cites W2332968657 @default.
• W2801812279 cites W2418710173 @default.
• W2801812279 cites W2472204272 @default.
• W2801812279 cites W2601059636 @default.
• W2801812279 cites W2760651017 @default.
• W2801812279 doi "https://doi.org/10.1113/jp275988" @default.
• W2801812279 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6092292" @default.
• W2801812279 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29737520" @default.
• W2801812279 hasPublicationYear "2018" @default.
• W2801812279 type Work @default.
• W2801812279 sameAs 2801812279 @default.
• W2801812279 citedByCount "18" @default.
• W2801812279 countsByYear W28018122792018 @default.
• W2801812279 countsByYear W28018122792019 @default.
• W2801812279 countsByYear W28018122792020 @default.
• W2801812279 countsByYear W28018122792021 @default.
• W2801812279 countsByYear W28018122792022 @default.
• W2801812279 countsByYear W28018122792023 @default.
• W2801812279 crossrefType "journal-article" @default.
• W2801812279 hasAuthorship W2801812279A5058888558 @default.
• W2801812279 hasAuthorship W2801812279A5067940438 @default.
• W2801812279 hasAuthorship W2801812279A5075080903 @default.
• W2801812279 hasAuthorship W2801812279A5089954997 @default.
• W2801812279 hasBestOaLocation W28018122791 @default.
• W2801812279 hasConcept C10146269 @default.
• W2801812279 hasConcept C126322002 @default.
• W2801812279 hasConcept C134018914 @default.
• W2801812279 hasConcept C174459258 @default.
• W2801812279 hasConcept C178790620 @default.
• W2801812279 hasConcept C185592680 @default.
• W2801812279 hasConcept C189135053 @default.
• W2801812279 hasConcept C202751555 @default.
• W2801812279 hasConcept C26291073 @default.
• W2801812279 hasConcept C2776069600 @default.
• W2801812279 hasConcept C2778525890 @default.
• W2801812279 hasConcept C2780072264 @default.
• W2801812279 hasConcept C2780091579 @default.
• W2801812279 hasConcept C2781231759 @default.
• W2801812279 hasConcept C537181965 @default.
• W2801812279 hasConcept C55493867 @default.
• W2801812279 hasConcept C56906281 @default.
• W2801812279 hasConcept C6507245 @default.
• W2801812279 hasConcept C71924100 @default.
• W2801812279 hasConcept C86803240 @default.
• W2801812279 hasConceptScore W2801812279C10146269 @default.
• W2801812279 hasConceptScore W2801812279C126322002 @default.
• W2801812279 hasConceptScore W2801812279C134018914 @default.
• W2801812279 hasConceptScore W2801812279C174459258 @default.
• W2801812279 hasConceptScore W2801812279C178790620 @default.
• W2801812279 hasConceptScore W2801812279C185592680 @default.
• W2801812279 hasConceptScore W2801812279C189135053 @default.
• W2801812279 hasConceptScore W2801812279C202751555 @default.
• W2801812279 hasConceptScore W2801812279C26291073 @default.
• W2801812279 hasConceptScore W2801812279C2776069600 @default.
• W2801812279 hasConceptScore W2801812279C2778525890 @default.
• W2801812279 hasConceptScore W2801812279C2780072264 @default.
• W2801812279 hasConceptScore W2801812279C2780091579 @default.

• next