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- W2801813225 endingPage "154" @default.
- W2801813225 startingPage "125" @default.
- W2801813225 abstract "Fifty years ago, Hepsin (HPN or TMPRSS1) was the first transmembrane serine protease (TTSP) discovered. Since then, a clear connection has been made between hepsin activity and many aspects of cancer. Of particular interest is hepsin's ability to promote a high invasive potential of cancer cells and tumors via at least two mechanisms; activation of stromal growth factors, such as HGF and MSP, and disruption of epithelial cohesion in the tumor. In addition, there are multiple other substrates processed by overactive hepsin, including other proteases implicated in tumorigenesis, which significantly expands the scope of pro-tumorigenic substrates. We provide a critical summary on recent studies that have explored the various physiological and pathophysiological roles of hepsin, while drawing attention to unanswered questions in the field and trends in pharmacological targeting of hepsin." @default.
- W2801813225 created "2018-05-17" @default.
- W2801813225 creator A5002954183 @default.
- W2801813225 creator A5006668187 @default.
- W2801813225 creator A5074241901 @default.
- W2801813225 creator A5086266029 @default.
- W2801813225 date "2018-05-11" @default.
- W2801813225 modified "2023-10-16" @default.
- W2801813225 title "The Cell-Surface, Transmembrane Serine Protease Hepsin: Discovery, Function and Role in Cancer" @default.
- W2801813225 cites W1505921511 @default.
- W2801813225 cites W1530114936 @default.
- W2801813225 cites W1546741081 @default.
- W2801813225 cites W1547743287 @default.
- W2801813225 cites W1575527051 @default.
- W2801813225 cites W1594507882 @default.
- W2801813225 cites W1601826601 @default.
- W2801813225 cites W1819876020 @default.
- W2801813225 cites W1831758208 @default.
- W2801813225 cites W1832976650 @default.
- W2801813225 cites W1920052832 @default.
- W2801813225 cites W1956057741 @default.
- W2801813225 cites W1962464218 @default.
- W2801813225 cites W1968375872 @default.
- W2801813225 cites W1969275365 @default.
- W2801813225 cites W1969754678 @default.
- W2801813225 cites W1974353811 @default.
- W2801813225 cites W1976200608 @default.
- W2801813225 cites W1978123763 @default.
- W2801813225 cites W1980357331 @default.
- W2801813225 cites W1980792579 @default.
- W2801813225 cites W1983586409 @default.
- W2801813225 cites W1986115325 @default.
- W2801813225 cites W1986791248 @default.
- W2801813225 cites W1989246187 @default.
- W2801813225 cites W1996547492 @default.
- W2801813225 cites W1997696802 @default.
- W2801813225 cites W1999836692 @default.
- W2801813225 cites W2004032902 @default.
- W2801813225 cites W2010720904 @default.
- W2801813225 cites W2012080977 @default.
- W2801813225 cites W2012411473 @default.
- W2801813225 cites W2016021454 @default.
- W2801813225 cites W2016591815 @default.
- W2801813225 cites W2019436999 @default.
- W2801813225 cites W2021179643 @default.
- W2801813225 cites W2024213404 @default.
- W2801813225 cites W2025991307 @default.
- W2801813225 cites W2028068087 @default.
- W2801813225 cites W2032430075 @default.
- W2801813225 cites W2034454344 @default.
- W2801813225 cites W2036359252 @default.
- W2801813225 cites W2036902495 @default.
- W2801813225 cites W2037562795 @default.
- W2801813225 cites W2040862545 @default.
- W2801813225 cites W2042141383 @default.
- W2801813225 cites W2044874695 @default.
- W2801813225 cites W2046218382 @default.
- W2801813225 cites W2046597264 @default.
- W2801813225 cites W2049831508 @default.
- W2801813225 cites W2050481433 @default.
- W2801813225 cites W2057074411 @default.
- W2801813225 cites W2058481056 @default.
- W2801813225 cites W2059590594 @default.
- W2801813225 cites W2060396407 @default.
- W2801813225 cites W2061064073 @default.
- W2801813225 cites W2062919894 @default.
- W2801813225 cites W2066031703 @default.
- W2801813225 cites W2066348409 @default.
- W2801813225 cites W2067602854 @default.
- W2801813225 cites W2069849774 @default.
- W2801813225 cites W2070823430 @default.
- W2801813225 cites W2072021567 @default.
- W2801813225 cites W2073260533 @default.
- W2801813225 cites W2076054862 @default.
- W2801813225 cites W2076583198 @default.
- W2801813225 cites W2078129772 @default.
- W2801813225 cites W2079069107 @default.
- W2801813225 cites W2081160315 @default.
- W2801813225 cites W2081990983 @default.
- W2801813225 cites W2082573867 @default.
- W2801813225 cites W2083231458 @default.
- W2801813225 cites W2085903671 @default.
- W2801813225 cites W2086342587 @default.
- W2801813225 cites W2089509586 @default.
- W2801813225 cites W2089557515 @default.
- W2801813225 cites W2091567243 @default.
- W2801813225 cites W2094337993 @default.
- W2801813225 cites W2095233604 @default.
- W2801813225 cites W2096154341 @default.
- W2801813225 cites W2097771036 @default.
- W2801813225 cites W2100638553 @default.
- W2801813225 cites W2102629949 @default.
- W2801813225 cites W2107625861 @default.
- W2801813225 cites W2114843025 @default.
- W2801813225 cites W2117164669 @default.
- W2801813225 cites W2118488518 @default.
- W2801813225 cites W2120547622 @default.
- W2801813225 cites W2121793978 @default.