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• W2801813479 abstract "Cryoglobulinemia is a common extrahepatic manifestation of infection with hepatitis C virus (HCV). When signs and symptoms of systemic vasculitis or glomerulonephritis occur in the presence of circulating cryoglobulins, this syndrome is called mixed cryoglobulinemia syndrome (MCS). Historically, interferon-based therapies in HCV have been associated with lower rates of viral cure in patients with MCS than in the general HCV-infected population. The advent of direct-acting antiviral therapies have revolutionized the treatment of HCV, dramatically increasing rates of cure. Early studies of first-generation protease inhibitors (telaprevir and boceprevir) in combination with interferon and ribavirin demonstrated HCV cure rates of 67% and complete clinical response rates of vasculitis symptoms in 60% of patients with MCS; however, regimens were poorly tolerated by patients, 22% discontinued treatment early. More recently, all-oral, interferon-free regimens have become available and combination therapies are now being approved for patients with and without renal impairment. Patients with HCV-MCS achieved sustained virologic response in 297 out of 313 patients (95%) treated with direct-acting antiviral therapy, and 85% had a complete or partial clinical response of MCS symptoms. Current direct-acting antiviral therapies are well tolerated in patients with HCV-MCS and only 1.6% discontinued treatment early. Patients with cryoglobulinemic glomerulonephritis also had an excellent cure rate (94%). The majority improved; 17/52 (33%) experienced full remission and 15/52 (29%) experienced partial remission. There were no reports of worsening kidney function in patients treated with direct-acting antiviral therapies. Less than 5% of patients with HCV-MCS treated with IFN-free direct-acting antiviral therapy required immunosuppression. However, patients with severe vasculitis appear to still require concomitant immunosuppression." @default.
• W2801813479 created "2018-05-17" @default.
• W2801813479 creator A5009285146 @default.
• W2801813479 creator A5020069661 @default.
• W2801813479 creator A5048669465 @default.
• W2801813479 date "2018-04-01" @default.
• W2801813479 modified "2023-10-17" @default.
• W2801813479 title "Treatment of hepatitis C virus infection in patients with mixed cryoglobulinemic syndrome and cryoglobulinemic glomerulonephritis" @default.
• W2801813479 cites W152531107 @default.
• W2801813479 cites W1699970495 @default.
• W2801813479 cites W1874082200 @default.
• W2801813479 cites W1908153784 @default.
• W2801813479 cites W1970673979 @default.
• W2801813479 cites W1975639393 @default.
• W2801813479 cites W1978985019 @default.
• W2801813479 cites W1979922467 @default.
• W2801813479 cites W1983621878 @default.
• W2801813479 cites W1983770985 @default.
• W2801813479 cites W1986416046 @default.
• W2801813479 cites W1992119953 @default.
• W2801813479 cites W1992134262 @default.
• W2801813479 cites W1995186488 @default.
• W2801813479 cites W1996134375 @default.
• W2801813479 cites W1996171607 @default.
• W2801813479 cites W1997403962 @default.
• W2801813479 cites W2008211463 @default.
• W2801813479 cites W2008387097 @default.
• W2801813479 cites W2016553185 @default.
• W2801813479 cites W2016731955 @default.
• W2801813479 cites W2017544558 @default.
• W2801813479 cites W2019985783 @default.
• W2801813479 cites W2028453745 @default.
• W2801813479 cites W2031867843 @default.
• W2801813479 cites W2037493638 @default.
• W2801813479 cites W2043273269 @default.
• W2801813479 cites W2044784043 @default.
• W2801813479 cites W2045762096 @default.
• W2801813479 cites W2047859692 @default.
• W2801813479 cites W2056179599 @default.
• W2801813479 cites W2058975912 @default.
• W2801813479 cites W2061389251 @default.
• W2801813479 cites W2063760041 @default.
• W2801813479 cites W2064650635 @default.
• W2801813479 cites W2077477264 @default.
• W2801813479 cites W2078572625 @default.
• W2801813479 cites W2078764851 @default.
• W2801813479 cites W2079455469 @default.
• W2801813479 cites W2090887217 @default.
• W2801813479 cites W2092148787 @default.
• W2801813479 cites W2095400646 @default.
• W2801813479 cites W2097557603 @default.
• W2801813479 cites W2099665302 @default.
• W2801813479 cites W2101896088 @default.
• W2801813479 cites W2111559593 @default.
• W2801813479 cites W2112876622 @default.
• W2801813479 cites W2117786286 @default.
• W2801813479 cites W2119737080 @default.
• W2801813479 cites W2120706571 @default.
• W2801813479 cites W2138835266 @default.
• W2801813479 cites W2140084624 @default.
• W2801813479 cites W2145583169 @default.
• W2801813479 cites W2145814334 @default.
• W2801813479 cites W2148387413 @default.
• W2801813479 cites W2151487580 @default.
• W2801813479 cites W2156343854 @default.
• W2801813479 cites W2157551016 @default.
• W2801813479 cites W2158977173 @default.
• W2801813479 cites W2159501914 @default.
• W2801813479 cites W2165505664 @default.
• W2801813479 cites W2165542457 @default.
• W2801813479 cites W2165868468 @default.
• W2801813479 cites W2178797117 @default.
• W2801813479 cites W2217275225 @default.
• W2801813479 cites W2226298026 @default.
• W2801813479 cites W2230018632 @default.
• W2801813479 cites W2261086347 @default.
• W2801813479 cites W2284028703 @default.
• W2801813479 cites W2292010270 @default.
• W2801813479 cites W2296452901 @default.
• W2801813479 cites W2312265932 @default.
• W2801813479 cites W2320330796 @default.
• W2801813479 cites W2324507396 @default.
• W2801813479 cites W2411832526 @default.
• W2801813479 cites W2472716744 @default.
• W2801813479 cites W2495198776 @default.
• W2801813479 cites W2531120609 @default.
• W2801813479 cites W2565117603 @default.
• W2801813479 cites W2589793552 @default.
• W2801813479 cites W2592906740 @default.
• W2801813479 cites W2594752891 @default.
• W2801813479 cites W2610347748 @default.
• W2801813479 cites W2613250737 @default.
• W2801813479 cites W2613466210 @default.
• W2801813479 cites W2740157005 @default.
• W2801813479 cites W4247261611 @default.
• W2801813479 cites W87791214 @default.
• W2801813479 cites W92849675 @default.
• W2801813479 doi "https://doi.org/10.1111/hdi.12649" @default.
• W2801813479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29694729" @default.
• W2801813479 hasPublicationYear "2018" @default.

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