FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801818224> ?p ?o ?g. }

• W2801818224 abstract "Maintaining variation in immune genes, such as those of the major histocompatibility complex (MHC), is important for individuals in small, isolated populations to resist pathogens and parasites. The golden snub-nosed monkey (Rhinopithecus roxellana), an endangered primate endemic to China, has experienced a rapid reduction in numbers and severe population fragmentation over recent years. For this study, we measured the DRB diversity among 122 monkeys from three populations in the Qinling Mountains, and estimated the relative importance of different agents of selection in maintaining variation of DRB genes. We identified a total of 19 DRB sequences, in which five alleles were novel. We found high DRB variation in R. roxellana and three branches of evidence suggesting that balancing selection has contributed to maintaining MHC polymorphism over the long term in this species: i) different patterns of both genetic diversity and population differentiation were detected at MHC and neutral markers; ii) an excess of non-synonymous substitutions compared to synonymous substitutions at antigen binding sites, and maximum-likelihood-based random-site models, showed significant positive selection; and iii) phylogenetic analyses revealed a pattern of trans-species evolution for DRB genes. High levels of DRB diversity in these R. roxellana populations may reflect strong selection pressure in this species. Patterns of genetic diversity and population differentiation, positive selection, as well as trans-species evolution, suggest that pathogen-mediated balancing selection has contributed to maintaining MHC polymorphism in R. roxellana over the long term. This study furthers our understanding of the role pathogen-mediated balancing selection has in maintaining variation in MHC genes in small and fragmented populations of free-ranging vertebrates." @default.
• W2801818224 created "2018-05-17" @default.
• W2801818224 creator A5034579880 @default.
• W2801818224 creator A5047096950 @default.
• W2801818224 creator A5055063396 @default.
• W2801818224 creator A5055813479 @default.
• W2801818224 creator A5062152210 @default.
• W2801818224 creator A5075652202 @default.
• W2801818224 creator A5076269532 @default.
• W2801818224 creator A5077901649 @default.
• W2801818224 creator A5088768684 @default.
• W2801818224 date "2018-03-13" @default.
• W2801818224 modified "2023-10-13" @default.
• W2801818224 title "High polymorphism in MHC-DRB genes in golden snub-nosed monkeys reveals balancing selection in small, isolated populations" @default.
• W2801818224 cites W1495382765 @default.
• W2801818224 cites W1550819366 @default.
• W2801818224 cites W1580159074 @default.
• W2801818224 cites W1605924365 @default.
• W2801818224 cites W1652383174 @default.
• W2801818224 cites W1675884059 @default.
• W2801818224 cites W1773403432 @default.
• W2801818224 cites W1907806866 @default.
• W2801818224 cites W1916463466 @default.
• W2801818224 cites W1962445093 @default.
• W2801818224 cites W1969042907 @default.
• W2801818224 cites W1972024510 @default.
• W2801818224 cites W1976844960 @default.
• W2801818224 cites W1981776932 @default.
• W2801818224 cites W1987760570 @default.
• W2801818224 cites W1989100119 @default.
• W2801818224 cites W1990352386 @default.
• W2801818224 cites W1997645529 @default.
• W2801818224 cites W2002820206 @default.
• W2801818224 cites W2004444667 @default.
• W2801818224 cites W2007630815 @default.
• W2801818224 cites W2013075345 @default.
• W2801818224 cites W2014873782 @default.
• W2801818224 cites W2021671312 @default.
• W2801818224 cites W2023711349 @default.
• W2801818224 cites W2024060531 @default.
• W2801818224 cites W2026498036 @default.
• W2801818224 cites W2029042859 @default.
• W2801818224 cites W2032178747 @default.
• W2801818224 cites W2039435867 @default.
• W2801818224 cites W2040455177 @default.
• W2801818224 cites W2041842205 @default.
• W2801818224 cites W2047417387 @default.
• W2801818224 cites W2060533361 @default.
• W2801818224 cites W2073495424 @default.
• W2801818224 cites W2073621589 @default.
• W2801818224 cites W2077312152 @default.
• W2801818224 cites W2077861902 @default.
• W2801818224 cites W2085221932 @default.
• W2801818224 cites W2092818382 @default.
• W2801818224 cites W2097834336 @default.
• W2801818224 cites W2098073190 @default.
• W2801818224 cites W2103532924 @default.
• W2801818224 cites W2104324648 @default.
• W2801818224 cites W2107130747 @default.
• W2801818224 cites W2107473082 @default.
• W2801818224 cites W2109737895 @default.
• W2801818224 cites W2110335151 @default.
• W2801818224 cites W2111092513 @default.
• W2801818224 cites W2111211467 @default.
• W2801818224 cites W2111716323 @default.
• W2801818224 cites W2113307627 @default.
• W2801818224 cites W2115034207 @default.
• W2801818224 cites W2117489889 @default.
• W2801818224 cites W2118726322 @default.
• W2801818224 cites W2120056890 @default.
• W2801818224 cites W2127396309 @default.
• W2801818224 cites W2129979981 @default.
• W2801818224 cites W2130783116 @default.
• W2801818224 cites W2133837428 @default.
• W2801818224 cites W2136847298 @default.
• W2801818224 cites W2137015675 @default.
• W2801818224 cites W2144368480 @default.
• W2801818224 cites W2146058063 @default.
• W2801818224 cites W2146124483 @default.
• W2801818224 cites W2149664101 @default.
• W2801818224 cites W2151897100 @default.
• W2801818224 cites W2154845780 @default.
• W2801818224 cites W2155408399 @default.
• W2801818224 cites W2156380818 @default.
• W2801818224 cites W2157285699 @default.
• W2801818224 cites W2160327332 @default.
• W2801818224 cites W2163104222 @default.
• W2801818224 cites W2166186418 @default.
• W2801818224 cites W2179698814 @default.
• W2801818224 cites W2311203695 @default.
• W2801818224 cites W2326749627 @default.
• W2801818224 cites W2517159532 @default.
• W2801818224 cites W2581693831 @default.
• W2801818224 cites W3012079654 @default.
• W2801818224 doi "https://doi.org/10.1186/s12862-018-1148-7" @default.
• W2801818224 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5851093" @default.
• W2801818224 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29534675" @default.
• W2801818224 hasPublicationYear "2018" @default.
• W2801818224 type Work @default.
• W2801818224 sameAs 2801818224 @default.

• next