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- W2801824327 abstract "The epithelium of the intestine functions as the primary, frontline, physical barrier for protection from enteric microbiota. Intraepithelial lymphocytes (IELs) distributed along the intestinal epithelium are predominantly CD8+ T cells, among which CD8αβ+ IELs are a large population. In this investigation, the proportion and absolute number of CD8αβ+ IELs decreased significantly, in both antibiotic-treated and germ-free mice. Moreover, CD8αβ+ IELs were positively correlated with the diversity of commensal microbes, especially Bacteroidetes and Actinobacteria. Microarray analysis revealed that CD8αβ+ IELs expressed a series of genes encoding potent antimicrobial peptides (AMPs), while CD8αβ+ splenocytes (SPLs) did not. The antimicrobial activity of CD8αβ+ IELs was confirmed by bactericidal assay. In conclusion, microbicidal CD8αβ+ IELs are regulated by commensal bacteria, which in turn, secrete AMPs that play a vital role in maintaining the homeostasis of the small intestine." @default.
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- W2801824327 date "2018-05-16" @default.
- W2801824327 modified "2023-10-06" @default.
- W2801824327 title "Commensal Bacteria-Dependent CD8αβ+ T Cells in the Intestinal Epithelium Produce Antimicrobial Peptides" @default.
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- W2801824327 doi "https://doi.org/10.3389/fimmu.2018.01065" @default.
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