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• W2801825541 abstract "Optimization of a chemical series originating from whole-cell phenotypic screening against the human malaria parasite, Plasmodium falciparum, led to the identification of two promising 2,6-disubstituted imidazopyridine compounds, 43 and 74. These compounds exhibited potent activity against asexual blood stage parasites that, together with their in vitro absorption, distribution, metabolism, and excretion (ADME) properties, translated to in vivo efficacy with clearance of parasites in the PfSCID mouse model for malaria within 48 h of treatment." @default.
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• W2801825541 date "2018-04-17" @default.
• W2801825541 modified "2023-10-18" @default.
• W2801825541 title "Identification of Fast-Acting 2,6-Disubstituted Imidazopyridines That Are Efficacious in the in Vivo Humanized <i>Plasmodium falciparum</i> NODscidIL2Rγ^<i>null</i> Mouse Model of Malaria" @default.
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• W2801825541 doi "https://doi.org/10.1021/acs.jmedchem.8b00382" @default.
• W2801825541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29665687" @default.
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