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- W2801826142 abstract "Reduced cerebral blood flow in Alzheimer's disease (AD) may occur in early AD, which contributes to the pathogenesis and/or pathological progression of AD. Reversing this deficit may have therapeutic potential. Certain traditional Chinese herbal medicines (e.g., Saponin and its major component Xueshuantong [XST]) increase blood flow in humans, but whether they could be effective in treating AD patients has not been tested. We found that systemic XST injection elevated cerebral blood flow in APP/PS1 transgenic mice using two-photon time-lapse imaging in the same microvessels before and after injection. Subchronic XST treatment led to improved spatial learning and memory and motor performance in the APP/PS1 mice, suggesting improved neural plasticity and functions. Two-photon time lapse imaging of the same plaques revealed a reduction in plaque size after XST treatment. In addition, western blots experiments showed that XST treatment led to reduced processing of amyloid-β protein precursor (AβPP) and enhanced clearance of amyloid-β (Aβ) without altering the total level of AβPP. We also found increased synapse density in the immediate vicinity of amyloid plaques, suggesting enhanced synaptic function. We conclude that targeting cerebral blood flow can be an effective strategy in treating AD." @default.
- W2801826142 created "2018-05-17" @default.
- W2801826142 creator A5008089351 @default.
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- W2801826142 creator A5038043249 @default.
- W2801826142 creator A5073548995 @default.
- W2801826142 creator A5074315977 @default.
- W2801826142 date "2018-05-08" @default.
- W2801826142 modified "2023-09-26" @default.
- W2801826142 title "Chinese Herbal Medicine Xueshuantong Enhances Cerebral Blood Flow and Improves Neural Functions in Alzheimer’s Disease Mice" @default.
- W2801826142 cites W1000383428 @default.
- W2801826142 cites W138828890 @default.
- W2801826142 cites W1440335865 @default.
- W2801826142 cites W1484446969 @default.
- W2801826142 cites W1509827081 @default.
- W2801826142 cites W1514559719 @default.
- W2801826142 cites W1594119953 @default.
- W2801826142 cites W1706021753 @default.
- W2801826142 cites W1725757145 @default.
- W2801826142 cites W1860952316 @default.
- W2801826142 cites W1923262640 @default.
- W2801826142 cites W1964065265 @default.
- W2801826142 cites W1965049154 @default.
- W2801826142 cites W1970016175 @default.
- W2801826142 cites W1972757313 @default.
- W2801826142 cites W1972776675 @default.
- W2801826142 cites W1976296246 @default.
- W2801826142 cites W1980101667 @default.
- W2801826142 cites W1981458288 @default.
- W2801826142 cites W1983889720 @default.
- W2801826142 cites W1990628576 @default.
- W2801826142 cites W1990752558 @default.
- W2801826142 cites W1994839798 @default.
- W2801826142 cites W1994898376 @default.
- W2801826142 cites W1998193695 @default.
- W2801826142 cites W1999856629 @default.
- W2801826142 cites W2001995688 @default.
- W2801826142 cites W2004371219 @default.
- W2801826142 cites W2005719973 @default.
- W2801826142 cites W2006035554 @default.
- W2801826142 cites W2007804566 @default.
- W2801826142 cites W2013848453 @default.
- W2801826142 cites W2015933608 @default.
- W2801826142 cites W2024715836 @default.
- W2801826142 cites W2027704676 @default.
- W2801826142 cites W2035814505 @default.
- W2801826142 cites W2037426713 @default.
- W2801826142 cites W2037615358 @default.
- W2801826142 cites W2040490831 @default.
- W2801826142 cites W2045562899 @default.
- W2801826142 cites W2049223366 @default.
- W2801826142 cites W2049801272 @default.
- W2801826142 cites W2053019147 @default.
- W2801826142 cites W2053288220 @default.
- W2801826142 cites W2054845211 @default.
- W2801826142 cites W2055775253 @default.
- W2801826142 cites W2057528026 @default.
- W2801826142 cites W2060629467 @default.
- W2801826142 cites W2063552863 @default.
- W2801826142 cites W2066916212 @default.
- W2801826142 cites W2075721398 @default.
- W2801826142 cites W2080612159 @default.
- W2801826142 cites W2081061369 @default.
- W2801826142 cites W2084484659 @default.
- W2801826142 cites W2097845219 @default.
- W2801826142 cites W2098090577 @default.
- W2801826142 cites W2098506866 @default.
- W2801826142 cites W2103105772 @default.
- W2801826142 cites W2111200377 @default.
- W2801826142 cites W2111698897 @default.
- W2801826142 cites W2113189139 @default.
- W2801826142 cites W2121469208 @default.
- W2801826142 cites W2130473558 @default.
- W2801826142 cites W2132154794 @default.
- W2801826142 cites W2132430755 @default.
- W2801826142 cites W2136389487 @default.
- W2801826142 cites W2136901555 @default.
- W2801826142 cites W2140781566 @default.
- W2801826142 cites W2144680439 @default.
- W2801826142 cites W2148196878 @default.
- W2801826142 cites W2149227806 @default.
- W2801826142 cites W2153386636 @default.
- W2801826142 cites W2156193029 @default.
- W2801826142 cites W2156434585 @default.
- W2801826142 cites W2159972803 @default.
- W2801826142 cites W2161512663 @default.
- W2801826142 cites W2162294352 @default.
- W2801826142 cites W2163916825 @default.
- W2801826142 cites W2164133449 @default.
- W2801826142 cites W2165329538 @default.
- W2801826142 cites W2165773859 @default.
- W2801826142 cites W2168139756 @default.
- W2801826142 cites W2169152986 @default.
- W2801826142 cites W2193492588 @default.
- W2801826142 cites W2275983367 @default.
- W2801826142 cites W2298163613 @default.
- W2801826142 cites W2329336071 @default.
- W2801826142 cites W2546627707 @default.