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- W2801832183 abstract "Glioblastoma (GBM) is the most common and malignant form of brain cancer. Even with aggressive standard of care, GBM almost always recurs because its diffuse, infiltrative nature makes these tumors difficult to treat. The use of biomaterials is one strategy that has been, and is being, employed to study and overcome recurrence. Biomaterials have been used in GBM in two ways: in vitro as mediums in which to model the tumor microenvironment, and in vivo to sustain release of cytotoxic therapeutics. In vitro systems are a useful platform for studying the effects of drugs and tissue-level effectors on tumor cells in a physiologically relevant context. These systems have aided examination of how glioma cells respond to a variety of natural, synthetic, and semi-synthetic biomaterials with varying substrate properties, biochemical factor presentations, and non-malignant parenchymal cell compositions in both 2D and 3D environments. The current in vivo paradigm is completely different, however. Polymeric implants are simply used to line the post-surgical resection cavities and deliver secondary therapies, offering moderate impacts on survival. Instead, perhaps we can use the data generated from in vitro systems to design novel biomaterial-based treatments for GBM akin to a tissue engineering approach. Here we offer our perspective on the topic, summarizing how biomaterials have been used to identify facets of glioma biology in vitro and discussing the elements that show promise for translating these systems in vivo as new therapies for GBM." @default.
- W2801832183 created "2018-05-17" @default.
- W2801832183 creator A5049365455 @default.
- W2801832183 creator A5089403507 @default.
- W2801832183 date "2018-05-09" @default.
- W2801832183 modified "2023-10-07" @default.
- W2801832183 title "Perspective on Translating Biomaterials Into Glioma Therapy: Lessons From in Vitro Models" @default.
- W2801832183 cites W1149703769 @default.
- W2801832183 cites W1179982327 @default.
- W2801832183 cites W1545028983 @default.
- W2801832183 cites W1587062732 @default.
- W2801832183 cites W1706016362 @default.
- W2801832183 cites W1952198731 @default.
- W2801832183 cites W1964467566 @default.
- W2801832183 cites W1970667811 @default.
- W2801832183 cites W1976096075 @default.
- W2801832183 cites W1976578289 @default.
- W2801832183 cites W1978496495 @default.
- W2801832183 cites W1979031104 @default.
- W2801832183 cites W1984242958 @default.
- W2801832183 cites W1989900532 @default.
- W2801832183 cites W1999272533 @default.
- W2801832183 cites W2000765473 @default.
- W2801832183 cites W2001244335 @default.
- W2801832183 cites W2001717792 @default.
- W2801832183 cites W2006211736 @default.
- W2801832183 cites W2021328900 @default.
- W2801832183 cites W2029939001 @default.
- W2801832183 cites W2032159281 @default.
- W2801832183 cites W2034699234 @default.
- W2801832183 cites W2035833975 @default.
- W2801832183 cites W2039110110 @default.
- W2801832183 cites W2039123767 @default.
- W2801832183 cites W2042301629 @default.
- W2801832183 cites W2042739950 @default.
- W2801832183 cites W2044099175 @default.
- W2801832183 cites W2044905529 @default.
- W2801832183 cites W2045727892 @default.
- W2801832183 cites W2047848650 @default.
- W2801832183 cites W2049132016 @default.
- W2801832183 cites W2063192133 @default.
- W2801832183 cites W2069121320 @default.
- W2801832183 cites W2070380716 @default.
- W2801832183 cites W2072134878 @default.
- W2801832183 cites W2073586533 @default.
- W2801832183 cites W2076181442 @default.
- W2801832183 cites W2077636669 @default.
- W2801832183 cites W2077796307 @default.
- W2801832183 cites W2082064020 @default.
- W2801832183 cites W2083926481 @default.
- W2801832183 cites W2085039514 @default.
- W2801832183 cites W2087124977 @default.
- W2801832183 cites W2087217642 @default.
- W2801832183 cites W2095301611 @default.
- W2801832183 cites W2097730243 @default.
- W2801832183 cites W2098291603 @default.
- W2801832183 cites W2102435763 @default.
- W2801832183 cites W2109949410 @default.
- W2801832183 cites W2117692326 @default.
- W2801832183 cites W2118217096 @default.
- W2801832183 cites W2118687720 @default.
- W2801832183 cites W2125867824 @default.
- W2801832183 cites W2127059375 @default.
- W2801832183 cites W2130606072 @default.
- W2801832183 cites W2131388477 @default.
- W2801832183 cites W2134208433 @default.
- W2801832183 cites W2137281600 @default.
- W2801832183 cites W2146369144 @default.
- W2801832183 cites W2148328262 @default.
- W2801832183 cites W2159146836 @default.
- W2801832183 cites W2162442448 @default.
- W2801832183 cites W2165418665 @default.
- W2801832183 cites W2167548068 @default.
- W2801832183 cites W2208179253 @default.
- W2801832183 cites W2228176134 @default.
- W2801832183 cites W2280099094 @default.
- W2801832183 cites W2299770017 @default.
- W2801832183 cites W2300474316 @default.
- W2801832183 cites W2312801312 @default.
- W2801832183 cites W2317086255 @default.
- W2801832183 cites W2325549616 @default.
- W2801832183 cites W2342710074 @default.
- W2801832183 cites W2395943362 @default.
- W2801832183 cites W2482354189 @default.
- W2801832183 cites W2513245519 @default.
- W2801832183 cites W2514834940 @default.
- W2801832183 cites W2535545320 @default.
- W2801832183 cites W2547097019 @default.
- W2801832183 cites W2555999948 @default.
- W2801832183 cites W2572174216 @default.
- W2801832183 cites W2593090407 @default.
- W2801832183 cites W2602907732 @default.
- W2801832183 cites W2612526085 @default.
- W2801832183 cites W2616779259 @default.
- W2801832183 cites W2624407975 @default.
- W2801832183 cites W2624969848 @default.
- W2801832183 cites W2669701283 @default.
- W2801832183 cites W2737053924 @default.
- W2801832183 cites W2738678436 @default.
- W2801832183 cites W2744061893 @default.