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• W2801833334 endingPage "437" @default.
• W2801833334 startingPage "422" @default.
• W2801833334 abstract "G-protein coupled receptors are transmembrane proteins widely expressed in cells and their transduction pathways are mediated by controlling second messenger levels through different G-protein interactions. Many of these receptors have been described as involved in the physiopathology of neurodegenerative diseases and even considered as potential targets for the design of novel therapeutic strategies. Endogenous and synthetic allosteric and orthosteric selective ligands are able to modulate GPCRs at both gene and protein expression levels and can also modify their physiological function. GPCRs that coexist in the same cells can homo- and heteromerize, therefore, modulating their function. Adenosine receptors are GPCRs which stimulate or inhibit adenylyl cyclase activity through Gi/Gs protein and are involved in the control of neurotransmitter release as glutamate. In turn, metabotropic glutamate receptors are also GPCRs which inhibit adenylyl cyclase or stimulate phospholipase C activities through Gi or Gq proteins, respectively. In recent years, evidence of crosstalk mechanisms between different GPCRs have been described. The aim of the present review was to summarize the described mechanisms of interaction and crosstalking between adenosine and metabotropic glutamate receptors, mainly of group I, in both in vitro and in vivo systems, and their possible use for the design of novel ligands for the treatment of neurodegenerative diseases." @default.
• W2801833334 created "2018-05-17" @default.
• W2801833334 creator A5015818040 @default.
• W2801833334 creator A5028519120 @default.
• W2801833334 creator A5043968216 @default.
• W2801833334 date "2019-04-05" @default.
• W2801833334 modified "2023-09-30" @default.
• W2801833334 title "Functional Cross-Talk between Adenosine and Metabotropic Glutamate Receptors" @default.
• W2801833334 cites W120668892 @default.
• W2801833334 cites W1515771616 @default.
• W2801833334 cites W1520494904 @default.
• W2801833334 cites W1582463035 @default.
• W2801833334 cites W1597618230 @default.
• W2801833334 cites W1745453754 @default.
• W2801833334 cites W1756488067 @default.
• W2801833334 cites W1870995349 @default.
• W2801833334 cites W1878156379 @default.
• W2801833334 cites W1965058020 @default.
• W2801833334 cites W1965280907 @default.
• W2801833334 cites W1969059511 @default.
• W2801833334 cites W1970208411 @default.
• W2801833334 cites W1973019877 @default.
• W2801833334 cites W1974100733 @default.
• W2801833334 cites W1975391500 @default.
• W2801833334 cites W1976264651 @default.
• W2801833334 cites W1976937534 @default.
• W2801833334 cites W1979707864 @default.
• W2801833334 cites W1980292799 @default.
• W2801833334 cites W1984575490 @default.
• W2801833334 cites W1988887233 @default.
• W2801833334 cites W1990583167 @default.
• W2801833334 cites W1995808589 @default.
• W2801833334 cites W2000187790 @default.
• W2801833334 cites W2002944804 @default.
• W2801833334 cites W2003293902 @default.
• W2801833334 cites W2005911006 @default.
• W2801833334 cites W2007635892 @default.
• W2801833334 cites W2009504616 @default.
• W2801833334 cites W2010345210 @default.
• W2801833334 cites W2011676677 @default.
• W2801833334 cites W2012249601 @default.
• W2801833334 cites W2013432476 @default.
• W2801833334 cites W2014365582 @default.
• W2801833334 cites W2016036161 @default.
• W2801833334 cites W2018596625 @default.
• W2801833334 cites W2022320148 @default.
• W2801833334 cites W2026669832 @default.
• W2801833334 cites W2027045807 @default.
• W2801833334 cites W2027567709 @default.
• W2801833334 cites W2028174628 @default.
• W2801833334 cites W2028291889 @default.
• W2801833334 cites W2031326058 @default.
• W2801833334 cites W2033308894 @default.
• W2801833334 cites W2033359106 @default.
• W2801833334 cites W2035064565 @default.
• W2801833334 cites W2038031154 @default.
• W2801833334 cites W2039164791 @default.
• W2801833334 cites W2040164212 @default.
• W2801833334 cites W2042651745 @default.
• W2801833334 cites W2044301280 @default.
• W2801833334 cites W2044504465 @default.
• W2801833334 cites W2045517073 @default.
• W2801833334 cites W2051618673 @default.
• W2801833334 cites W2054418249 @default.
• W2801833334 cites W2056083897 @default.
• W2801833334 cites W2057646479 @default.
• W2801833334 cites W2058230858 @default.
• W2801833334 cites W2061484882 @default.
• W2801833334 cites W2062203382 @default.
• W2801833334 cites W2062214351 @default.
• W2801833334 cites W2063759211 @default.
• W2801833334 cites W2065219184 @default.
• W2801833334 cites W2065765661 @default.
• W2801833334 cites W2066143615 @default.
• W2801833334 cites W2067993922 @default.
• W2801833334 cites W2075074068 @default.
• W2801833334 cites W2077182260 @default.
• W2801833334 cites W2079815480 @default.
• W2801833334 cites W2082015966 @default.
• W2801833334 cites W2085234888 @default.
• W2801833334 cites W2087137226 @default.
• W2801833334 cites W2088816845 @default.
• W2801833334 cites W2090879617 @default.
• W2801833334 cites W2093462331 @default.
• W2801833334 cites W2093613221 @default.
• W2801833334 cites W2093640268 @default.
• W2801833334 cites W2104084108 @default.
• W2801833334 cites W2105706450 @default.
• W2801833334 cites W2106307937 @default.
• W2801833334 cites W2106588046 @default.
• W2801833334 cites W2107608518 @default.
• W2801833334 cites W2107889592 @default.
• W2801833334 cites W2111669702 @default.
• W2801833334 cites W2118428474 @default.
• W2801833334 cites W2119660954 @default.
• W2801833334 cites W2120774984 @default.
• W2801833334 cites W2121315957 @default.
• W2801833334 cites W2122629591 @default.

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