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• W2801838700 abstract "The workpresented in this thesis describes the improvement and application of on-tissuechemistry for in-situ biomolecular analysis using matrix assisted-laserdesorption/ionization mass spectrometry imaging (MALDI-MSI). We have proposednew methodologies, applying on-tissue (enzymatic) chemistry, to increase themolecular information obtained in a MALDI-MSI analysis. We have also developedan automated histology-guided MSI platform, based on state-of-the-art imageprocessing tools, to facilitate high mass and spatial resolution MALDI-MSIwhile maintaining reasonable data loads and acquisition times. We have shownthe importance of these methods in a clinical biomarker discovery study onmyxoid liposarcoma tissues." @default.
• W2801838700 created "2018-05-17" @default.
• W2801838700 creator A5027181844 @default.
• W2801838700 date "2018-02-01" @default.
• W2801838700 modified "2023-09-27" @default.
• W2801838700 title "Lab-on-a-tissue : optimization of on-tissue chemistry for improved mass spectrometry imaging" @default.
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