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• W2801864057 endingPage "928" @default.
• W2801864057 startingPage "919" @default.
• W2801864057 abstract "Abstract The response of diffuse noxious inhibitory controls (DNIC) is often decreased, or lost, in stress-related functional pain syndromes. Because the dynorphin/kappa opioid receptor (KOR) pathway is activated by stress, we determined its role in DNIC using a model of stress-induced functional pain. Male, Sprague-Dawley rats were primed for 7 days with systemic morphine resulting in opioid-induced hyperalgesia. Fourteen days after priming, when hyperalgesia was resolved, rats were exposed to environmental stress and DNIC was evaluated by measuring hind paw response threshold to noxious pressure (test stimulus) after capsaicin injection in the forepaw (conditioning stimulus). Morphine priming without stress did not alter DNIC. However, stress produced a loss of DNIC in morphine-primed rats in both hind paws that was abolished by systemic administration of the KOR antagonist, nor-binaltorphimine (nor-BNI). Microinjection of nor-BNI into the right, but not left, central nucleus of the amygdala (CeA) prevented the loss of DNIC in morphine-primed rats. Diffuse noxious inhibitory controls were not modulated by bilateral nor-BNI in the rostral ventromedial medulla. Stress increased dynorphin content in both the left and right CeA of primed rats, reaching significance only in the right CeA; no change was observed in the rostral ventromedial medulla or hypothalamus. Although morphine priming alone is not sufficient to influence DNIC, it establishes a state of latent sensitization that amplifies the consequences of stress. After priming, stress-induced dynorphin/KOR signaling from the right CeA inhibits DNIC in both hind paws, likely reflecting enhanced descending facilitation that masks descending inhibition. Kappa opioid receptor antagonists may provide a new therapeutic strategy for stress-related functional pain disorders." @default.
• W2801864057 created "2018-05-17" @default.
• W2801864057 creator A5031986992 @default.
• W2801864057 creator A5051893058 @default.
• W2801864057 creator A5054742181 @default.
• W2801864057 creator A5057290642 @default.
• W2801864057 creator A5064145604 @default.
• W2801864057 creator A5070703610 @default.
• W2801864057 creator A5071744431 @default.
• W2801864057 date "2018-01-23" @default.
• W2801864057 modified "2023-10-17" @default.
• W2801864057 title "Lateralized kappa opioid receptor signaling from the amygdala central nucleus promotes stress-induced functional pain" @default.
• W2801864057 cites W1206417 @default.
• W2801864057 cites W130613889 @default.
• W2801864057 cites W1534753621 @default.
• W2801864057 cites W1554769608 @default.
• W2801864057 cites W1650998670 @default.
• W2801864057 cites W1862521538 @default.
• W2801864057 cites W1893441331 @default.
• W2801864057 cites W1932601697 @default.
• W2801864057 cites W1957870570 @default.
• W2801864057 cites W1966165954 @default.
• W2801864057 cites W1967320240 @default.
• W2801864057 cites W1968255213 @default.
• W2801864057 cites W1969164050 @default.
• W2801864057 cites W1978337893 @default.
• W2801864057 cites W1979031324 @default.
• W2801864057 cites W1981183620 @default.
• W2801864057 cites W1981291046 @default.
• W2801864057 cites W1983754627 @default.
• W2801864057 cites W1992384753 @default.
• W2801864057 cites W1994463719 @default.
• W2801864057 cites W1998077078 @default.
• W2801864057 cites W2001390859 @default.
• W2801864057 cites W2004198953 @default.
• W2801864057 cites W2004607543 @default.
• W2801864057 cites W2008201027 @default.
• W2801864057 cites W2010654991 @default.
• W2801864057 cites W2011008924 @default.
• W2801864057 cites W2015647807 @default.
• W2801864057 cites W2016117330 @default.
• W2801864057 cites W2018516085 @default.
• W2801864057 cites W2020888218 @default.
• W2801864057 cites W2029543844 @default.
• W2801864057 cites W2029584624 @default.
• W2801864057 cites W2034818541 @default.
• W2801864057 cites W2036395037 @default.
• W2801864057 cites W2040015969 @default.
• W2801864057 cites W2040642697 @default.
• W2801864057 cites W2041074598 @default.
• W2801864057 cites W2046562881 @default.
• W2801864057 cites W2047059474 @default.
• W2801864057 cites W2047196117 @default.
• W2801864057 cites W2048203787 @default.
• W2801864057 cites W2056804151 @default.
• W2801864057 cites W20614366 @default.
• W2801864057 cites W2062106032 @default.
• W2801864057 cites W2062645254 @default.
• W2801864057 cites W2064153996 @default.
• W2801864057 cites W2066001783 @default.
• W2801864057 cites W2072295990 @default.
• W2801864057 cites W2073166018 @default.
• W2801864057 cites W2077423745 @default.
• W2801864057 cites W2078674553 @default.
• W2801864057 cites W2078919602 @default.
• W2801864057 cites W2085255270 @default.
• W2801864057 cites W2087484885 @default.
• W2801864057 cites W2093481212 @default.
• W2801864057 cites W2103351070 @default.
• W2801864057 cites W2103387735 @default.
• W2801864057 cites W2111637761 @default.
• W2801864057 cites W2117634117 @default.
• W2801864057 cites W2121366273 @default.
• W2801864057 cites W2124163204 @default.
• W2801864057 cites W2127282142 @default.
• W2801864057 cites W2129239485 @default.
• W2801864057 cites W2134528446 @default.
• W2801864057 cites W2135984999 @default.
• W2801864057 cites W2140257707 @default.
• W2801864057 cites W2141317828 @default.
• W2801864057 cites W2142607990 @default.
• W2801864057 cites W2144694293 @default.
• W2801864057 cites W2145062794 @default.
• W2801864057 cites W2145416185 @default.
• W2801864057 cites W2159259673 @default.
• W2801864057 cites W2163486949 @default.
• W2801864057 cites W2169923097 @default.
• W2801864057 cites W2193936724 @default.
• W2801864057 cites W2264583664 @default.
• W2801864057 cites W2286862607 @default.
• W2801864057 cites W2400490632 @default.
• W2801864057 cites W2402044500 @default.
• W2801864057 cites W2409837131 @default.
• W2801864057 cites W2415752306 @default.
• W2801864057 cites W2416725998 @default.
• W2801864057 cites W2490063784 @default.
• W2801864057 cites W2516807182 @default.
• W2801864057 cites W2604616342 @default.

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