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• W2801884311 abstract "Background and objectiveMalaria and tuberculosis remain endemic in tropical regions and most often coexist, increasing the burden of malaria mortality due to unintended interactions of the co-administered drugs employed in the management of the infections. Rifampicin (RIF) and amodiaquine (ADQ) are likely to be administered concurrently in the treatment of patients with tuberculosis and malaria. The metabolism of ADQ is mediated principally by CYP2C8, while RIF is a known inducer of this enzyme. This study, therefore, investigated the effect of RIF on the disposition of ADQ, a major partner drug in the first-line treatment against uncomplicated malaria in line with the World Health Organization recommendations." @default.
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• W2801884311 date "2018-05-07" @default.
• W2801884311 modified "2023-09-24" @default.
• W2801884311 title "Induction of Amodiaquine Metabolism by Rifampicin Following Concurrent Administration in Healthy Volunteers" @default.
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• W2801884311 doi "https://doi.org/10.14218/jerp.2017.00024" @default.
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