Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801895273> ?p ?o ?g. }
- W2801895273 endingPage "104162" @default.
- W2801895273 startingPage "104162" @default.
- W2801895273 abstract "Schizophrenia is one of the leading causes of disability among mental disorders, contributing to a substantial socioeconomic burden. Our understanding of the mechanisms of the pathogenesis of the disease has largely been limited by its inherent complexity imparted by the polygenicity and interactions with environmental factors. Since pathobiological events are initiated in the schizophrenic brain long before the onset of the psychotic manifestations, characterizing these processes is limited, mainly due to a lack of access to neuronal tissues. Induced pluripotent stem cell (iPSC) technologies have provided an unprecedented opportunity to establish pluripotent stem cells from patients with schizophrenia and differentiate them into neuronal lineage, enabling an in vitro recapitulation of the pathogenesis of the disease. Despite the inherent challenges, patient-derived iPSC studies of schizophrenia have been instrumental in unraveling the cellular and molecular phenotypes that might be involved in the biological causality. Here we review the literature and focus on studies that have utilized patient-derived iPSCs to model the pathogenesis of schizophrenia. We also discuss the challenges in modeling cellular phenotypes of schizophrenia." @default.
- W2801895273 created "2018-05-17" @default.
- W2801895273 creator A5042225294 @default.
- W2801895273 creator A5061632695 @default.
- W2801895273 creator A5091434146 @default.
- W2801895273 date "2019-11-01" @default.
- W2801895273 modified "2023-09-25" @default.
- W2801895273 title "Contribution of induced pluripotent stem cell technologies to the understanding of cellular phenotypes in schizophrenia" @default.
- W2801895273 cites W1139979201 @default.
- W2801895273 cites W1490681631 @default.
- W2801895273 cites W1518890501 @default.
- W2801895273 cites W1533589220 @default.
- W2801895273 cites W1553983967 @default.
- W2801895273 cites W1635914561 @default.
- W2801895273 cites W1671213273 @default.
- W2801895273 cites W1763415643 @default.
- W2801895273 cites W1806909159 @default.
- W2801895273 cites W1814175552 @default.
- W2801895273 cites W1919947890 @default.
- W2801895273 cites W1944444102 @default.
- W2801895273 cites W1963673462 @default.
- W2801895273 cites W1964520813 @default.
- W2801895273 cites W1966171594 @default.
- W2801895273 cites W1968461255 @default.
- W2801895273 cites W1983660707 @default.
- W2801895273 cites W1991107962 @default.
- W2801895273 cites W1993206740 @default.
- W2801895273 cites W1994646065 @default.
- W2801895273 cites W1997031801 @default.
- W2801895273 cites W2000418014 @default.
- W2801895273 cites W2000502968 @default.
- W2801895273 cites W2003244159 @default.
- W2801895273 cites W2003253047 @default.
- W2801895273 cites W2009026745 @default.
- W2801895273 cites W2015206670 @default.
- W2801895273 cites W2018286352 @default.
- W2801895273 cites W2020837920 @default.
- W2801895273 cites W2021710989 @default.
- W2801895273 cites W2022069616 @default.
- W2801895273 cites W2028878165 @default.
- W2801895273 cites W2034460442 @default.
- W2801895273 cites W2034882293 @default.
- W2801895273 cites W2036030316 @default.
- W2801895273 cites W2036796020 @default.
- W2801895273 cites W2040789766 @default.
- W2801895273 cites W2040988960 @default.
- W2801895273 cites W2059627860 @default.
- W2801895273 cites W2060271985 @default.
- W2801895273 cites W2060801754 @default.
- W2801895273 cites W2065073047 @default.
- W2801895273 cites W2066735856 @default.
- W2801895273 cites W2069721797 @default.
- W2801895273 cites W2081914422 @default.
- W2801895273 cites W2082223061 @default.
- W2801895273 cites W2087316628 @default.
- W2801895273 cites W2088016850 @default.
- W2801895273 cites W2088170464 @default.
- W2801895273 cites W2089993812 @default.
- W2801895273 cites W2095546080 @default.
- W2801895273 cites W2097030222 @default.
- W2801895273 cites W2099756187 @default.
- W2801895273 cites W2101357408 @default.
- W2801895273 cites W2102722285 @default.
- W2801895273 cites W2108968692 @default.
- W2801895273 cites W2109143011 @default.
- W2801895273 cites W2110747892 @default.
- W2801895273 cites W2118922889 @default.
- W2801895273 cites W2121180328 @default.
- W2801895273 cites W2121398326 @default.
- W2801895273 cites W2125987139 @default.
- W2801895273 cites W2126580353 @default.
- W2801895273 cites W2133447500 @default.
- W2801895273 cites W2134581110 @default.
- W2801895273 cites W2136541538 @default.
- W2801895273 cites W2136801447 @default.
- W2801895273 cites W2136929119 @default.
- W2801895273 cites W2137228851 @default.
- W2801895273 cites W2138977668 @default.
- W2801895273 cites W2144035284 @default.
- W2801895273 cites W2145098771 @default.
- W2801895273 cites W2148828403 @default.
- W2801895273 cites W2155061287 @default.
- W2801895273 cites W2156568057 @default.
- W2801895273 cites W2157142964 @default.
- W2801895273 cites W2157645703 @default.
- W2801895273 cites W2165312126 @default.
- W2801895273 cites W2166506784 @default.
- W2801895273 cites W2195294260 @default.
- W2801895273 cites W2281703724 @default.
- W2801895273 cites W2293879246 @default.
- W2801895273 cites W2342348020 @default.
- W2801895273 cites W2347191528 @default.
- W2801895273 cites W2407632744 @default.
- W2801895273 cites W2416331529 @default.
- W2801895273 cites W2463246198 @default.
- W2801895273 cites W2467511189 @default.
- W2801895273 cites W2515897135 @default.
- W2801895273 cites W2531162526 @default.