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• W2801896156 abstract "Abstract The mechanisms that ensure fertilization of eggs by a single sperm are not fully understood. In all teleosts, a channel called the ‘micropyle’ is the only route of entry for sperm to enter and fertilize the egg. The micropyle forms by penetration of the developing vitelline envelope by a single specialized follicle cell, the micropylar cell, which subsequently degenerates. The mechanisms underlying micropylar cell specification and micropyle formation are poorly understood. Here, we show that an effector of the Hippo signaling pathway, the Transcriptional co-activator with a PDZ-binding domain (Taz), plays crucial roles in micropyle formation and fertilization in zebrafish. Genome editing mutants affecting taz can grow to adults, however, eggs from homozygous taz females are not fertilized even though oocytes in mutant females are histologically normal with intact animal-vegetal polarity, complete meiosis and proper ovulation. However, taz mutant eggs have no micropyle. We show that Taz protein is specifically enriched from mid-oogenesis onwards in two follicle cells located at the animal pole of the oocyte, and co-localizes with the actin and tubulin cytoskeleton. Taz protein and micropylar cell are not detected in taz mutant ovaries. Our work identifies a novel role for the Hippo/Taz pathway in micropylar cell specification in zebrafish, and uncovers the molecular basis of micropyle formation in teleosts." @default.
• W2801896156 created "2018-05-17" @default.
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• W2801896156 date "2018-05-10" @default.
• W2801896156 modified "2023-09-27" @default.
• W2801896156 title "The effector of Hippo signaling, Taz, is required for formation of the micropyle and fertilization in zebrafish" @default.
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• W2801896156 doi "https://doi.org/10.1101/319475" @default.
• W2801896156 hasPublicationYear "2018" @default.
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