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• W280196329 abstract "Non-muscle myosin-IIA (NMIIA) belongs to an ATP-dependent family of motor-proteins mainly involved in processes that require force and motility. This molecule is capable of binding to actin. Via this interaction NMIIA mediates contractility and actin-based motility. Thus NMIIA is capable of mediating several key cellular functions such as: division, migration, polarity and cytoskeletal stability. NMIIA is also involved in intracellular vesicular transport, including retrograde transport of cargo from the Trans-Golgi Network (TGN) back to the Endoplasmic Reticulum (ER) to undergo proteosomal degradation. In our laboratory we study NMIIA functions both in infection and regular physiological conditions. Previous work from our laboratory demonstrated that depletion of NMIIA by siRNA favoured the invasion of host cells by Listeria monocytogenes. Given the involvement of this protein in cytoskeleton regulation and infection it is in our interest to increase our knowledge about it. A yeast two-hybrid (Y2H) screen was performed as a starting point to study NMIIA and its interacting partners. Out of 97 positive interactions we selected 5 putative interactive partners and used biochemical techniques to confirm their association with NMIIA. From the five a total of two became increasingly relevant through the realization of this project: beta-adaptin and heat-shock protein 56 (Hsp56). Throughout the work performed in the framework of this project we observed a possible association between NMIIA and Hsp56 and also between NMIIA and beta-adaptin. This possible association was suggested by the results obtained using immunoprecipitation (IP). Discovery of a functional and physiological role for these possible NMIIA interacting partners, in a regular physiological context and in an infection context, is the next step in this project. We expect our work will allow a better understanding of NMIIA and therefore increase our knowledge about the influence of this protein on cytoskeleton regulation, intracellular vesicular transport and ultimately bacterial infection." @default.
• W280196329 created "2016-06-24" @default.
• W280196329 creator A5033920371 @default.
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• W280196329 date "2013-11-29" @default.
• W280196329 modified "2023-09-26" @default.
• W280196329 title "Identification of novel non-muscle myosin IIA (NMIIA) interacting partners" @default.
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