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- W2801969057 abstract "Foxp3+ regulatory T (Treg) cells constitute about 5-10% of peripheral CD4+ T cells and maintain immunological self-tolerance. We previously reported that thymus-derived Treg cells formed clusters with dendritic cells (DCs) were expanded to ∼ 60% of the CD4+ T cells in the skin after ultraviolet B (UVB) exposure. In this study, we further investigated a critical skin DC subset to expand Treg cells. We found that UVB were able to expand Treg cells without Langerhans cells in a CSF1-independent manner. The critical skin DC subset in the UVB-exposed skin was PD-L1+ and highly expressed a unique set of genes associated with immunological tolerance. The DC contributed to proliferation of Treg cells both in vitro and in vivo. These results indicate that there is a specialized DC subset in the UVB-exposed skin to expand Treg cells, which suppress autoimmunity. Further understanding of the functions of the DC subset in the UVB-exposed skin would enable expanding antigen-specific Treg cells for the treatment of autoimmunity, allergy and graft rejection in the skin." @default.
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- W2801969057 date "2018-05-01" @default.
- W2801969057 modified "2023-09-30" @default.
- W2801969057 title "1123 Foxp3+ regulatory T cells are expanded by ultraviolet B-exposed PD-L1+ skin dendritic cell expressing a unique set of genes in a CSF1-independent manner" @default.
- W2801969057 doi "https://doi.org/10.1016/j.jid.2018.03.1137" @default.
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