FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801981571> ?p ?o ?g. }

• W2801981571 abstract "Previous work has explored links between mitochondrial biology and fungal pathogenicity in F1Fo-ATP synthase in Candida albicans. In this work we have detailed the more specific roles of the F1Fo-ATP synthase β subunit, a key protein subunit of F1Fo-ATP synthase. The ability to assimilate alternative carbons in glucose-limited host niches is known to be a critical factor for C. albicans infection. The function of the F1Fo-ATP synthase β subunit was characterized through the construction of an ATP2 gene null mutant (atp2Δ/Δ) and the gene-reconstituted strain (atp2Δ/ATP2) in order to understand the link between carbon metabolism and C. albicans pathogenesis. Cell growth, viability, cellular ATP content, mitochondrial membrane potential (ΔΨm) and intracellular ROS were compared between null mutant and control strain. Results showed that growth of the atp2Δ/Δ mutant in synthetic medium was slower than in complex medium. However, the synthetic medium delayed the onset of reduced cell viability and kept cellular ATP content from becoming fully depleted. Consistent with these observations, we identified transcriptional changes in metabolic response that activated other ATP-generating pathways, thereby improving cell viability during the initial phase. Unlike glucose effects, the atp2Δ/Δ mutant exhibited an immediate and sharp reduction in cell viability on non-fermentable carbon sources, consistent with an immediate depletion of cellular ATP content. Along with a reduced viability in non-fermentable carbon sources, the atp2Δ/Δ mutant displayed avirulence in a murine model of disseminated candidiasis as well as lower fungal loads in mouse organs. Regardless of the medium, however, a decrease in mitochondrial membrane potential (ΔΨm) was found in the atp2Δ/Δ mutant but ROS levels remained in the normal range. These results suggest that the F1Fo-ATP synthase β subunit is required for C. albicans pathogenicity and operates by affecting metabolic flexibility in carbon consumption." @default.
• W2801981571 created "2018-05-17" @default.
• W2801981571 creator A5002562718 @default.
• W2801981571 creator A5004702985 @default.
• W2801981571 creator A5028896959 @default.
• W2801981571 creator A5029434966 @default.
• W2801981571 creator A5031396879 @default.
• W2801981571 creator A5032744520 @default.
• W2801981571 creator A5061769699 @default.
• W2801981571 creator A5062665642 @default.
• W2801981571 creator A5074378852 @default.
• W2801981571 date "2018-05-23" @default.
• W2801981571 modified "2023-10-14" @default.
• W2801981571 title "The F1Fo-ATP Synthase β Subunit Is Required for Candida albicans Pathogenicity Due to Its Role in Carbon Flexibility" @default.
• W2801981571 cites W1488105116 @default.
• W2801981571 cites W1517182194 @default.
• W2801981571 cites W16101172 @default.
• W2801981571 cites W1647692986 @default.
• W2801981571 cites W1918199612 @default.
• W2801981571 cites W1922319616 @default.
• W2801981571 cites W1933263342 @default.
• W2801981571 cites W1963332331 @default.
• W2801981571 cites W1987928733 @default.
• W2801981571 cites W1990474165 @default.
• W2801981571 cites W1990831187 @default.
• W2801981571 cites W2001454891 @default.
• W2801981571 cites W2001798370 @default.
• W2801981571 cites W2009326252 @default.
• W2801981571 cites W2019870956 @default.
• W2801981571 cites W2026514003 @default.
• W2801981571 cites W2050590499 @default.
• W2801981571 cites W2053909542 @default.
• W2801981571 cites W2060721894 @default.
• W2801981571 cites W2080808704 @default.
• W2801981571 cites W2087238371 @default.
• W2801981571 cites W2097338792 @default.
• W2801981571 cites W2104259060 @default.
• W2801981571 cites W2106519526 @default.
• W2801981571 cites W2107794472 @default.
• W2801981571 cites W2114950068 @default.
• W2801981571 cites W2116721311 @default.
• W2801981571 cites W2136956922 @default.
• W2801981571 cites W2144035662 @default.
• W2801981571 cites W2149373720 @default.
• W2801981571 cites W2154431984 @default.
• W2801981571 cites W2155416658 @default.
• W2801981571 cites W2158658436 @default.
• W2801981571 cites W2166117618 @default.
• W2801981571 cites W2170551349 @default.
• W2801981571 cites W2171901564 @default.
• W2801981571 cites W2179438025 @default.
• W2801981571 cites W2215630817 @default.
• W2801981571 cites W2489915703 @default.
• W2801981571 cites W2591066360 @default.
• W2801981571 cites W2621385485 @default.
• W2801981571 cites W341279500 @default.
• W2801981571 cites W4242684589 @default.
• W2801981571 doi "https://doi.org/10.3389/fmicb.2018.01025" @default.
• W2801981571 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5974098" @default.
• W2801981571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29875745" @default.
• W2801981571 hasPublicationYear "2018" @default.
• W2801981571 type Work @default.
• W2801981571 sameAs 2801981571 @default.
• W2801981571 citedByCount "15" @default.
• W2801981571 countsByYear W28019815712019 @default.
• W2801981571 countsByYear W28019815712020 @default.
• W2801981571 countsByYear W28019815712021 @default.
• W2801981571 countsByYear W28019815712022 @default.
• W2801981571 countsByYear W28019815712023 @default.
• W2801981571 crossrefType "journal-article" @default.
• W2801981571 hasAuthorship W2801981571A5002562718 @default.
• W2801981571 hasAuthorship W2801981571A5004702985 @default.
• W2801981571 hasAuthorship W2801981571A5028896959 @default.
• W2801981571 hasAuthorship W2801981571A5029434966 @default.
• W2801981571 hasAuthorship W2801981571A5031396879 @default.
• W2801981571 hasAuthorship W2801981571A5032744520 @default.
• W2801981571 hasAuthorship W2801981571A5061769699 @default.
• W2801981571 hasAuthorship W2801981571A5062665642 @default.
• W2801981571 hasAuthorship W2801981571A5074378852 @default.
• W2801981571 hasBestOaLocation W28019815711 @default.
• W2801981571 hasConcept C104292427 @default.
• W2801981571 hasConcept C104317684 @default.
• W2801981571 hasConcept C112243037 @default.
• W2801981571 hasConcept C143065580 @default.
• W2801981571 hasConcept C1491633281 @default.
• W2801981571 hasConcept C181199279 @default.
• W2801981571 hasConcept C191678065 @default.
• W2801981571 hasConcept C2780917455 @default.
• W2801981571 hasConcept C28406088 @default.
• W2801981571 hasConcept C28859421 @default.
• W2801981571 hasConcept C53227056 @default.
• W2801981571 hasConcept C55493867 @default.
• W2801981571 hasConcept C79879829 @default.
• W2801981571 hasConcept C86803240 @default.
• W2801981571 hasConcept C89423630 @default.
• W2801981571 hasConcept C95444343 @default.
• W2801981571 hasConceptScore W2801981571C104292427 @default.
• W2801981571 hasConceptScore W2801981571C104317684 @default.
• W2801981571 hasConceptScore W2801981571C112243037 @default.
• W2801981571 hasConceptScore W2801981571C143065580 @default.

• next