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- W2801985319 abstract "A spatiotemporal phase modulator (STPM) is theoretically investigated using the vectorial diffraction theory. The STPM is equivalent to a time-dependent phase-only pupil filter that alternates between a homogeneous filter and a stripe-shaped filter with a sinusoidal phase distribution. It is found that two-photon focal modulation microscopy (TPFMM) using this STPM can significantly suppress the background contribution from out-of-focus ballistic excitation and achieve almost the same resolution as two-photon microscopy. The modulation depth is also evaluated and a compromise exists between the signal-to-background ratio and signal-to-noise ratio. The theoretical investigations provide important insights into future implementations of TPFMM and its potential to further extend the penetration depth of nonlinear microscopy in imaging multiple-scattering biological tissues." @default.
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- W2801985319 date "2018-05-08" @default.
- W2801985319 modified "2023-09-26" @default.
- W2801985319 title "Numerical modeling of two-photon focal modulation microscopy with a sinusoidal phase filter" @default.
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- W2801985319 doi "https://doi.org/10.1117/1.jbo.23.5.055002" @default.
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