FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801997617> ?p ?o ?g. }

• W2801997617 abstract "Poor adherence to either antiretroviral treatment (ART) or pre-exposure prophylaxis (PrEP) can promote drug resistance, though this risk is thought to be considerably higher for ART. In the population of men who have sex with men (MSM) in San Francisco, PrEP coverage reached 9.6% in 2014 and has continued to rise. Given the risk of drug resistance and high cost of second-line drugs, the costs and benefits of initiating ART earlier while expanding PrEP coverage remain unclear.We develop an infection-age-structured mathematical model and fit this model to the annual incidence of AIDS cases and deaths directly, and to resistance and demographic data indirectly. We investigate the impact of six various intervention scenarios (low, medium, or high PrEP coverage, with or without earlier ART) over the next 20 years.Low (medium, high) PrEP coverage with earlier ART could prevent 22% (42%, 57%) of a projected 44,508 total new infections and 8% (26%, 41%) of a projected 18,426 new drug-resistant infections, and result in a gain of 43,649 (74,048, 103,270) QALYs over 20 years compared to the status quo, at a cost of $4745 ($78,811, $115,320) per QALY gained, respectively.High PrEP coverage with earlier ART is expected to provide the greatest benefit but also entail the highest costs among the strategies considered. This strategy is cost-effective for the San Francisco MSM population, even considering the acquisition and transmission of ART-mediated drug resistance. However, without a substantial increase to San Francisco's annual HIV budget, the most advisable strategy may be initiating ART earlier, while maintaining current strategies of PrEP enrollment." @default.
• W2801997617 created "2018-05-17" @default.
• W2801997617 creator A5013892545 @default.
• W2801997617 creator A5016498166 @default.
• W2801997617 creator A5022540617 @default.
• W2801997617 creator A5034031384 @default.
• W2801997617 creator A5087071544 @default.
• W2801997617 date "2018-04-24" @default.
• W2801997617 modified "2023-10-18" @default.
• W2801997617 title "The cost-effectiveness of oral HIV pre-exposure prophylaxis and early antiretroviral therapy in the presence of drug resistance among men who have sex with men in San Francisco" @default.
• W2801997617 cites W1413161224 @default.
• W2801997617 cites W1971644621 @default.
• W2801997617 cites W1975011541 @default.
• W2801997617 cites W1976028120 @default.
• W2801997617 cites W1976594098 @default.
• W2801997617 cites W1981177608 @default.
• W2801997617 cites W1991541076 @default.
• W2801997617 cites W2001602693 @default.
• W2801997617 cites W2002570479 @default.
• W2801997617 cites W2007452261 @default.
• W2801997617 cites W2017736583 @default.
• W2801997617 cites W2029513457 @default.
• W2801997617 cites W2038188944 @default.
• W2801997617 cites W2039617800 @default.
• W2801997617 cites W2044096763 @default.
• W2801997617 cites W2047690132 @default.
• W2801997617 cites W2050621055 @default.
• W2801997617 cites W2061231131 @default.
• W2801997617 cites W2065159982 @default.
• W2801997617 cites W2065719742 @default.
• W2801997617 cites W2078776195 @default.
• W2801997617 cites W2082116635 @default.
• W2801997617 cites W2082146526 @default.
• W2801997617 cites W2083267401 @default.
• W2801997617 cites W2096293642 @default.
• W2801997617 cites W2098100768 @default.
• W2801997617 cites W2103920597 @default.
• W2801997617 cites W2104239905 @default.
• W2801997617 cites W2111888273 @default.
• W2801997617 cites W2119989719 @default.
• W2801997617 cites W2123618756 @default.
• W2801997617 cites W2126401413 @default.
• W2801997617 cites W2133053181 @default.
• W2801997617 cites W2146634980 @default.
• W2801997617 cites W2150644408 @default.
• W2801997617 cites W2152505869 @default.
• W2801997617 cites W2157921853 @default.
• W2801997617 cites W2159263888 @default.
• W2801997617 cites W2160615372 @default.
• W2801997617 cites W2169595126 @default.
• W2801997617 cites W2299643502 @default.
• W2801997617 cites W2310590569 @default.
• W2801997617 cites W2312573952 @default.
• W2801997617 cites W2319917590 @default.
• W2801997617 cites W2339189374 @default.
• W2801997617 cites W2342800497 @default.
• W2801997617 cites W2344477929 @default.
• W2801997617 cites W2427561303 @default.
• W2801997617 cites W2469591829 @default.
• W2801997617 cites W2512045947 @default.
• W2801997617 cites W2732030379 @default.
• W2801997617 doi "https://doi.org/10.1186/s12916-018-1047-1" @default.
• W2801997617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5914040" @default.
• W2801997617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29688862" @default.
• W2801997617 hasPublicationYear "2018" @default.
• W2801997617 type Work @default.
• W2801997617 sameAs 2801997617 @default.
• W2801997617 citedByCount "23" @default.
• W2801997617 countsByYear W28019976172019 @default.
• W2801997617 countsByYear W28019976172020 @default.
• W2801997617 countsByYear W28019976172021 @default.
• W2801997617 countsByYear W28019976172022 @default.
• W2801997617 countsByYear W28019976172023 @default.
• W2801997617 crossrefType "journal-article" @default.
• W2801997617 hasAuthorship W2801997617A5013892545 @default.
• W2801997617 hasAuthorship W2801997617A5016498166 @default.
• W2801997617 hasAuthorship W2801997617A5022540617 @default.
• W2801997617 hasAuthorship W2801997617A5034031384 @default.
• W2801997617 hasAuthorship W2801997617A5087071544 @default.
• W2801997617 hasBestOaLocation W28019976171 @default.
• W2801997617 hasConcept C114851261 @default.
• W2801997617 hasConcept C120665830 @default.
• W2801997617 hasConcept C121332964 @default.
• W2801997617 hasConcept C142462285 @default.
• W2801997617 hasConcept C144024400 @default.
• W2801997617 hasConcept C149923435 @default.
• W2801997617 hasConcept C2776939746 @default.
• W2801997617 hasConcept C2776983459 @default.
• W2801997617 hasConcept C2777931914 @default.
• W2801997617 hasConcept C2779496540 @default.
• W2801997617 hasConcept C2908647359 @default.
• W2801997617 hasConcept C2993143319 @default.
• W2801997617 hasConcept C3013748606 @default.
• W2801997617 hasConcept C512399662 @default.
• W2801997617 hasConcept C61511704 @default.
• W2801997617 hasConcept C71924100 @default.
• W2801997617 hasConcept C74909509 @default.
• W2801997617 hasConcept C86803240 @default.
• W2801997617 hasConcept C89423630 @default.
• W2801997617 hasConcept C99454951 @default.

• next