FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2801998423> ?p ?o ?g. }

• W2801998423 endingPage "5834" @default.
• W2801998423 startingPage "5820" @default.
• W2801998423 abstract "Core-shell nanoparticles receive much attention for their current and potential applications in life sciences. Commonly, a dense shell of hydrated polymer, a polymer brush, is grafted to improve colloidal stability of functional nanoparticles and to prevent protein adsorption, aggregation, cell recognition, and uptake. Until recently, it was widely assumed that a polymer brush shell indeed prevents strong association of proteins and that this leads to their superior stealth properties in vitro and in vivo. We show using T-dependent isothermal titration calorimetry on well-characterized monodisperse superparamagnetic iron oxide nanoparticles with controlled dense stealth polymer brush shells that stealth core-shell nanoparticles display significant attractive exothermic and enthalpic interactions with serum proteins, despite having excellent colloidal stability and negligible nonspecific cell uptake. This observation is at room temperature shown to depend only weakly on variation of iron oxide core diameter and type of grafted stealth polymer: poly(ethylene glycol), poly(ethyl oxazoline), poly(isopropyl oxazoline), and poly( N-isopropyl acrylamide). Polymer brush shells with a critical solution temperature close to body temperature showed a strong temperature dependence in their interactions with proteins with a significant increase in protein binding energy with increased temperature. The stoichiometry of interaction is estimated to be near 1:1 for PEGylated nanoparticles and up to 10:1 for larger thermoresponsive nanoparticles, whereas the average free energy of interaction is enthalpically driven and comparable to a weak hydrogen bond." @default.
• W2801998423 created "2018-05-17" @default.
• W2801998423 creator A5041685218 @default.
• W2801998423 creator A5057969078 @default.
• W2801998423 creator A5087360561 @default.
• W2801998423 date "2018-05-04" @default.
• W2801998423 modified "2023-10-16" @default.
• W2801998423 title "Stealth Nanoparticles Grafted with Dense Polymer Brushes Display Adsorption of Serum Protein Investigated by Isothermal Titration Calorimetry" @default.
• W2801998423 cites W1478059225 @default.
• W2801998423 cites W1835515365 @default.
• W2801998423 cites W1908809260 @default.
• W2801998423 cites W1967732157 @default.
• W2801998423 cites W1967765471 @default.
• W2801998423 cites W1970216421 @default.
• W2801998423 cites W1972835273 @default.
• W2801998423 cites W1990063775 @default.
• W2801998423 cites W1990173308 @default.
• W2801998423 cites W2009805582 @default.
• W2801998423 cites W2028756849 @default.
• W2801998423 cites W2029102853 @default.
• W2801998423 cites W2048393999 @default.
• W2801998423 cites W2050886209 @default.
• W2801998423 cites W2054981131 @default.
• W2801998423 cites W2057691802 @default.
• W2801998423 cites W2057910069 @default.
• W2801998423 cites W2059201273 @default.
• W2801998423 cites W2065725244 @default.
• W2801998423 cites W2072457545 @default.
• W2801998423 cites W2086393160 @default.
• W2801998423 cites W2089155556 @default.
• W2801998423 cites W2090757591 @default.
• W2801998423 cites W2091993106 @default.
• W2801998423 cites W2126346850 @default.
• W2801998423 cites W2148250546 @default.
• W2801998423 cites W2151007161 @default.
• W2801998423 cites W2152272673 @default.
• W2801998423 cites W2158558808 @default.
• W2801998423 cites W2163021050 @default.
• W2801998423 cites W2164841185 @default.
• W2801998423 cites W2271636378 @default.
• W2801998423 cites W2284550715 @default.
• W2801998423 cites W2322891651 @default.
• W2801998423 cites W2327979197 @default.
• W2801998423 cites W2402319960 @default.
• W2801998423 cites W2415944425 @default.
• W2801998423 cites W2421275313 @default.
• W2801998423 cites W2512015681 @default.
• W2801998423 cites W2519048620 @default.
• W2801998423 cites W2539691763 @default.
• W2801998423 cites W2567453467 @default.
• W2801998423 cites W2567925929 @default.
• W2801998423 cites W2570342360 @default.
• W2801998423 cites W2578173452 @default.
• W2801998423 cites W2604942927 @default.
• W2801998423 cites W2609203566 @default.
• W2801998423 cites W2610836576 @default.
• W2801998423 cites W2799543967 @default.
• W2801998423 cites W2951836488 @default.
• W2801998423 cites W2000518188 @default.
• W2801998423 doi "https://doi.org/10.1021/acs.jpcb.8b02338" @default.
• W2801998423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5994724" @default.
• W2801998423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29726682" @default.
• W2801998423 hasPublicationYear "2018" @default.
• W2801998423 type Work @default.
• W2801998423 sameAs 2801998423 @default.
• W2801998423 citedByCount "36" @default.
• W2801998423 countsByYear W28019984232018 @default.
• W2801998423 countsByYear W28019984232019 @default.
• W2801998423 countsByYear W28019984232020 @default.
• W2801998423 countsByYear W28019984232021 @default.
• W2801998423 countsByYear W28019984232022 @default.
• W2801998423 countsByYear W28019984232023 @default.
• W2801998423 crossrefType "journal-article" @default.
• W2801998423 hasAuthorship W2801998423A5041685218 @default.
• W2801998423 hasAuthorship W2801998423A5057969078 @default.
• W2801998423 hasAuthorship W2801998423A5087360561 @default.
• W2801998423 hasBestOaLocation W28019984231 @default.
• W2801998423 hasConcept C115260700 @default.
• W2801998423 hasConcept C121332964 @default.
• W2801998423 hasConcept C127413603 @default.
• W2801998423 hasConcept C147789679 @default.
• W2801998423 hasConcept C155672457 @default.
• W2801998423 hasConcept C156911925 @default.
• W2801998423 hasConcept C15920480 @default.
• W2801998423 hasConcept C171250308 @default.
• W2801998423 hasConcept C178790620 @default.
• W2801998423 hasConcept C185592680 @default.
• W2801998423 hasConcept C188027245 @default.
• W2801998423 hasConcept C188109995 @default.
• W2801998423 hasConcept C192562407 @default.
• W2801998423 hasConcept C23792430 @default.
• W2801998423 hasConcept C2777516009 @default.
• W2801998423 hasConcept C2778889443 @default.
• W2801998423 hasConcept C32546565 @default.
• W2801998423 hasConcept C42360764 @default.
• W2801998423 hasConcept C521977710 @default.
• W2801998423 hasConcept C62520636 @default.
• W2801998423 hasConcept C88001094 @default.

• next