FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802000238> ?p ?o ?g. }

• W2802000238 endingPage "4976" @default.
• W2802000238 startingPage "4957" @default.
• W2802000238 abstract "The vomeronasal system (VNS) is a major vertebrate chemosensory system that functions in parallel to the main olfactory system (MOS). Despite many similarities, the two systems dramatically differ in the temporal domain. While MOS responses are governed by breathing and follow a subsecond temporal scale, VNS responses are uncoupled from breathing and evolve over seconds. This suggests that the contribution of response dynamics to stimulus information will differ between these systems. While temporal dynamics in the MOS are widely investigated, similar analyses in the accessory olfactory bulb (AOB) are lacking. Here, we have addressed this issue using controlled stimulus delivery to the vomeronasal organ of male and female mice. We first analyzed the temporal properties of AOB projection neurons and demonstrated that neurons display prolonged, variable, and neuron-specific characteristics. We then analyzed various decoding schemes using AOB population responses. We showed that compared with the simplest scheme (i.e., integration of spike counts over the entire response period), the division of this period into smaller temporal bins actually yields poorer decoding accuracy. However, optimal classification accuracy can be achieved well before the end of the response period by integrating spike counts within temporally defined windows. Since VNS stimulus uptake is variable, we analyzed decoding using limited information about stimulus uptake time, and showed that with enough neurons, such time-invariant decoding is feasible. Finally, we conducted simulations that demonstrated that, unlike the main olfactory bulb, the temporal features of AOB neurons disfavor decoding with high temporal accuracy, and, rather, support decoding without precise knowledge of stimulus uptake time. SIGNIFICANCE STATEMENT A key goal in sensory system research is to identify which metrics of neuronal activity are relevant for decoding stimulus features. Here, we describe the first systematic analysis of temporal coding in the vomeronasal system (VNS), a chemosensory system devoted to socially relevant cues. Compared with the main olfactory system, timescales of VNS function are inherently slower and variable. Using various analyses of real and simulated data, we show that the consideration of response times relative to stimulus uptake can aid the decoding of stimulus information from neuronal activity. However, response properties of accessory olfactory bulb neurons favor decoding schemes that do not rely on the precise timing of stimulus uptake. Such schemes are consistent with the variable nature of VNS stimulus uptake." @default.
• W2802000238 created "2018-05-17" @default.
• W2802000238 creator A5038963538 @default.
• W2802000238 creator A5077818522 @default.
• W2802000238 creator A5088901821 @default.
• W2802000238 date "2018-04-30" @default.
• W2802000238 modified "2023-09-25" @default.
• W2802000238 title "Temporal Response Properties of Accessory Olfactory Bulb Neurons: Limitations and Opportunities for Decoding" @default.
• W2802000238 cites W1906705898 @default.
• W2802000238 cites W1975452348 @default.
• W2802000238 cites W1976665194 @default.
• W2802000238 cites W1977040099 @default.
• W2802000238 cites W1988697672 @default.
• W2802000238 cites W1993079796 @default.
• W2802000238 cites W1996771239 @default.
• W2802000238 cites W1998462024 @default.
• W2802000238 cites W1999633796 @default.
• W2802000238 cites W2010918615 @default.
• W2802000238 cites W2016329811 @default.
• W2802000238 cites W2016952654 @default.
• W2802000238 cites W2022794140 @default.
• W2802000238 cites W2023527603 @default.
• W2802000238 cites W2028281435 @default.
• W2802000238 cites W2031608739 @default.
• W2802000238 cites W2040886375 @default.
• W2802000238 cites W2041586962 @default.
• W2802000238 cites W2054301707 @default.
• W2802000238 cites W2056134931 @default.
• W2802000238 cites W2063181420 @default.
• W2802000238 cites W2068679600 @default.
• W2802000238 cites W2075599929 @default.
• W2802000238 cites W2079111057 @default.
• W2802000238 cites W2079355379 @default.
• W2802000238 cites W2079793751 @default.
• W2802000238 cites W2087453951 @default.
• W2802000238 cites W2093597508 @default.
• W2802000238 cites W2113348447 @default.
• W2802000238 cites W2113370491 @default.
• W2802000238 cites W2114747787 @default.
• W2802000238 cites W2115491237 @default.
• W2802000238 cites W2124674257 @default.
• W2802000238 cites W2125255891 @default.
• W2802000238 cites W2143461176 @default.
• W2802000238 cites W2150659604 @default.
• W2802000238 cites W2152243497 @default.
• W2802000238 cites W2158698691 @default.
• W2802000238 cites W2158976454 @default.
• W2802000238 cites W2158981585 @default.
• W2802000238 cites W2170359674 @default.
• W2802000238 cites W2175955654 @default.
• W2802000238 cites W2217356867 @default.
• W2802000238 cites W2276803212 @default.
• W2802000238 cites W2289382976 @default.
• W2802000238 cites W2291069950 @default.
• W2802000238 cites W2300147461 @default.
• W2802000238 cites W2418516454 @default.
• W2802000238 cites W2584508119 @default.
• W2802000238 cites W2611694608 @default.
• W2802000238 cites W2750017704 @default.
• W2802000238 cites W4301042878 @default.
• W2802000238 doi "https://doi.org/10.1523/jneurosci.2091-17.2018" @default.
• W2802000238 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596120" @default.
• W2802000238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29712784" @default.
• W2802000238 hasPublicationYear "2018" @default.
• W2802000238 type Work @default.
• W2802000238 sameAs 2802000238 @default.
• W2802000238 citedByCount "10" @default.
• W2802000238 countsByYear W28020002382018 @default.
• W2802000238 countsByYear W28020002382019 @default.
• W2802000238 countsByYear W28020002382020 @default.
• W2802000238 countsByYear W28020002382021 @default.
• W2802000238 countsByYear W28020002382023 @default.
• W2802000238 crossrefType "journal-article" @default.
• W2802000238 hasAuthorship W2802000238A5038963538 @default.
• W2802000238 hasAuthorship W2802000238A5077818522 @default.
• W2802000238 hasAuthorship W2802000238A5088901821 @default.
• W2802000238 hasBestOaLocation W28020002381 @default.
• W2802000238 hasConcept C11413529 @default.
• W2802000238 hasConcept C15744967 @default.
• W2802000238 hasConcept C169760540 @default.
• W2802000238 hasConcept C201792869 @default.
• W2802000238 hasConcept C2779918689 @default.
• W2802000238 hasConcept C2780496858 @default.
• W2802000238 hasConcept C41008148 @default.
• W2802000238 hasConcept C49878776 @default.
• W2802000238 hasConcept C529278444 @default.
• W2802000238 hasConcept C542102704 @default.
• W2802000238 hasConcept C57273362 @default.
• W2802000238 hasConcept C86803240 @default.
• W2802000238 hasConcept C94487597 @default.
• W2802000238 hasConceptScore W2802000238C11413529 @default.
• W2802000238 hasConceptScore W2802000238C15744967 @default.
• W2802000238 hasConceptScore W2802000238C169760540 @default.
• W2802000238 hasConceptScore W2802000238C201792869 @default.
• W2802000238 hasConceptScore W2802000238C2779918689 @default.
• W2802000238 hasConceptScore W2802000238C2780496858 @default.
• W2802000238 hasConceptScore W2802000238C41008148 @default.
• W2802000238 hasConceptScore W2802000238C49878776 @default.

• next