FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802004304> ?p ?o ?g. }

• W2802004304 endingPage "873" @default.
• W2802004304 startingPage "866" @default.
• W2802004304 abstract "Kidney injury is a significant complication for patients undergoing hematopoietic cell transplantation (HCT), but few studies have prospectively examined changes in GFR in long-term survivors of HCT. We described the association between changes in GFR and all-cause mortality in patients up to 10 years after HCT.We conducted a prospective, observational cohort study of adult patients undergoing HCT at the Fred Hutchinson Cancer Center in Seattle, Washington from 2003 to 2015. Patients were followed from baseline, before conditioning therapy, until a maximum of 10 years after transplant. We used Cox proportional hazard models to examine the association between creatinine eGFR and all-cause mortality. We used time-dependent generalized estimating equations to examine risk factors for decreases in eGFR.A total of 434 patients (median age, 52 years; range, 18-76 years; 64% were men; 87% were white) were followed for a median 5.3 years after HCT. The largest decreases in eGFR occurred within the first year post-transplant, with the eGFR decreasing from a median of 98 ml/min per 1.73 m2 at baseline to 78 ml/min per 1.73 m2 by 1 year post-HCT. Two thirds of patients had an eGFR<90 ml/min per 1.73 m2 at 1 year after transplant. When modeled as a continuous variable, as eGFR declined from approximately 60 ml/min per 1.73 m2, the hazard of mortality progressively increased relative to a normal eGFR of 90 ml/min per 1.73 m2 (P<0.001). For example, when compared with an eGFR of 90 ml/min per 1.73 m2, the hazard ratios for eGFR of 60, 50, and 40 ml/min per 1.73 m2 are 1.15 (95% confidence interval, 0.87 to 1.53), 1.68 (95% confidence interval, 1.26 to 2.24), and 2.67 (95% confidence interval, 1.99 to 3.60), respectively. Diabetes, hypertension, acute graft versus host disease, and cytomegalovirus infection were independently associated with a decline in GFR, whereas calcineurin inhibitor levels, chronic graft versus host disease, and albuminuria were not.Adult HCT recipients have a high risk of decreased eGFR by 1 year after HCT. Although eGFR remains fairly stable thereafter, a decreased eGFR is significantly associated with higher risk of mortality, with a progressively increased risk as eGFR declines." @default.
• W2802004304 created "2018-05-17" @default.
• W2802004304 creator A5010186298 @default.
• W2802004304 creator A5023949296 @default.
• W2802004304 creator A5032915645 @default.
• W2802004304 creator A5033370630 @default.
• W2802004304 creator A5037538071 @default.
• W2802004304 creator A5061896269 @default.
• W2802004304 creator A5078843561 @default.
• W2802004304 date "2018-04-18" @default.
• W2802004304 modified "2023-10-14" @default.
• W2802004304 title "Changes in Glomerular Filtration Rate and Impact on Long-Term Survival among Adults after Hematopoietic Cell Transplantation" @default.
• W2802004304 cites W1985527383 @default.
• W2802004304 cites W1986098263 @default.
• W2802004304 cites W1993215990 @default.
• W2802004304 cites W1995090169 @default.
• W2802004304 cites W1999165120 @default.
• W2802004304 cites W2009943536 @default.
• W2802004304 cites W2037119492 @default.
• W2802004304 cites W2045254059 @default.
• W2802004304 cites W2049229230 @default.
• W2802004304 cites W2079466327 @default.
• W2802004304 cites W2089636012 @default.
• W2802004304 cites W2098025063 @default.
• W2802004304 cites W2110611041 @default.
• W2802004304 cites W2118625269 @default.
• W2802004304 cites W2127224360 @default.
• W2802004304 cites W2128854969 @default.
• W2802004304 cites W2136157556 @default.
• W2802004304 cites W2136998972 @default.
• W2802004304 cites W2153987356 @default.
• W2802004304 cites W2318099690 @default.
• W2802004304 cites W2414538242 @default.
• W2802004304 cites W2575972856 @default.
• W2802004304 cites W2746354396 @default.
• W2802004304 doi "https://doi.org/10.2215/cjn.10630917" @default.
• W2802004304 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5989688" @default.
• W2802004304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29669818" @default.
• W2802004304 hasPublicationYear "2018" @default.
• W2802004304 type Work @default.
• W2802004304 sameAs 2802004304 @default.
• W2802004304 citedByCount "30" @default.
• W2802004304 countsByYear W28020043042018 @default.
• W2802004304 countsByYear W28020043042019 @default.
• W2802004304 countsByYear W28020043042020 @default.
• W2802004304 countsByYear W28020043042021 @default.
• W2802004304 countsByYear W28020043042022 @default.
• W2802004304 countsByYear W28020043042023 @default.
• W2802004304 crossrefType "journal-article" @default.
• W2802004304 hasAuthorship W2802004304A5010186298 @default.
• W2802004304 hasAuthorship W2802004304A5023949296 @default.
• W2802004304 hasAuthorship W2802004304A5032915645 @default.
• W2802004304 hasAuthorship W2802004304A5033370630 @default.
• W2802004304 hasAuthorship W2802004304A5037538071 @default.
• W2802004304 hasAuthorship W2802004304A5061896269 @default.
• W2802004304 hasAuthorship W2802004304A5078843561 @default.
• W2802004304 hasBestOaLocation W28020043041 @default.
• W2802004304 hasConcept C109159458 @default.
• W2802004304 hasConcept C126322002 @default.
• W2802004304 hasConcept C126894567 @default.
• W2802004304 hasConcept C141071460 @default.
• W2802004304 hasConcept C159641895 @default.
• W2802004304 hasConcept C188816634 @default.
• W2802004304 hasConcept C207103383 @default.
• W2802004304 hasConcept C2777408962 @default.
• W2802004304 hasConcept C2780306776 @default.
• W2802004304 hasConcept C28328180 @default.
• W2802004304 hasConcept C2911091166 @default.
• W2802004304 hasConcept C2993713153 @default.
• W2802004304 hasConcept C44249647 @default.
• W2802004304 hasConcept C50382708 @default.
• W2802004304 hasConcept C54355233 @default.
• W2802004304 hasConcept C71924100 @default.
• W2802004304 hasConcept C86803240 @default.
• W2802004304 hasConcept C90924648 @default.
• W2802004304 hasConceptScore W2802004304C109159458 @default.
• W2802004304 hasConceptScore W2802004304C126322002 @default.
• W2802004304 hasConceptScore W2802004304C126894567 @default.
• W2802004304 hasConceptScore W2802004304C141071460 @default.
• W2802004304 hasConceptScore W2802004304C159641895 @default.
• W2802004304 hasConceptScore W2802004304C188816634 @default.
• W2802004304 hasConceptScore W2802004304C207103383 @default.
• W2802004304 hasConceptScore W2802004304C2777408962 @default.
• W2802004304 hasConceptScore W2802004304C2780306776 @default.
• W2802004304 hasConceptScore W2802004304C28328180 @default.
• W2802004304 hasConceptScore W2802004304C2911091166 @default.
• W2802004304 hasConceptScore W2802004304C2993713153 @default.
• W2802004304 hasConceptScore W2802004304C44249647 @default.
• W2802004304 hasConceptScore W2802004304C50382708 @default.
• W2802004304 hasConceptScore W2802004304C54355233 @default.
• W2802004304 hasConceptScore W2802004304C71924100 @default.
• W2802004304 hasConceptScore W2802004304C86803240 @default.
• W2802004304 hasConceptScore W2802004304C90924648 @default.
• W2802004304 hasIssue "6" @default.
• W2802004304 hasLocation W28020043041 @default.
• W2802004304 hasLocation W28020043042 @default.
• W2802004304 hasLocation W28020043043 @default.
• W2802004304 hasLocation W28020043044 @default.

• next