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- W2802022017 abstract "Streptomyces is a diverse group of gram-positive microorganisms characterised by a complex developmental cycle. Streptomycetes produce a number of antibiotics and other bioactive compounds used in the clinic. Most screening campaigns looking for new bioactive molecules from actinomycetes have been performed empirically, e.g., without considering whether the bacteria are growing under the best developmental conditions for secondary metabolite production. These screening campaigns were extremely productive and discovered a number of new bioactive compounds during the so-called golden age of antibiotics (until the 1980s). However, at present, there is a worrying bottleneck in drug discovery, and new experimental approaches are needed to improve the screening of natural actinomycetes. Streptomycetes are still the most important natural source of antibiotics and other bioactive compounds. They harbour many cryptic secondary metabolite pathways not expressed under classical laboratory cultures. Here, we review the new strategies that are being explored to overcome current challenges in drug discovery. In particular, we focus on those aimed at improving the differentiation of the antibiotic-producing mycelium stage in the laboratory." @default.
- W2802022017 created "2018-05-17" @default.
- W2802022017 creator A5034011155 @default.
- W2802022017 creator A5051793026 @default.
- W2802022017 date "1959-01-01" @default.
- W2802022017 modified "2023-10-14" @default.
- W2802022017 title "Microbiological and pharmacological studies of colistin sulfate and sodium colistinmethanesulfonate." @default.
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