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• W2802022785 abstract "BETA-ADRENERGIC BLOCKERS (β-blockers) represent a heterogeneous class of cardiovascular drugs with different characteristics regarding their pharmacologic properties and clinical effects. As a class, β-blockers have been around for more than 50 years, and their use in the chronic treatment of ischemic heart disease and heart failure is well established. 1 Frishman W.H. β-Adrenergic blockade in cardiovascular disease. J Cardiovasc Pharmacol Ther. 2013; 18: 310-319 Crossref PubMed Scopus (0) Google Scholar Currently, β-blockers are indicated as long-term therapy in patients with a history of prior myocardial infarction (associated with a lower reinfarction and mortality rate) and in patients with systolic heart failure (survival benefit). 2 Teo K.K. Yusuf S. Furberg C.D. Effects of prophylactic antiarrhythmic drug therapy in acute myocardial infarction. An overview of results from randomized controlled trials. JAMA. 1993; 270: 1589-1595 Crossref PubMed Google Scholar , 3 Brophy J.M. Joseph L. Rouleau J.L. Beta-blockers in congestive heart failure. A Bayesian meta-analysis. Ann Intern Med. 2001; 134: 550-560 Crossref PubMed Google Scholar Of note, β-blockers are not indicated as first-line therapy in patients with uncomplicated hypertension unless there is concomitant ischemic heart disease or heart failure. 4 Whelton P.K. Carey R.M. Aronow W.S. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2017; ([epub ahead of print]) Google Scholar However, their chronic use in patients with a history of myocardial infarction has been challenged recently. Contemporary studies have demonstrated limited mortality benefit when used for secondary prevention in patients who have suffered their first myocardial infarction unless there is evidence for heart failure. 5 Bangalore S. Steg G. Deedwania P. et al. β-Blocker use and clinical outcomes in stable outpatients with and without coronary artery disease. JAMA. 2012; 308: 1340-1349 Crossref PubMed Scopus (282) Google Scholar , 6 Abbasi J. Do all patients need β-blockers after a heart attack?. JAMA. 2018; 319: 853-855 Crossref PubMed Scopus (0) Google Scholar" @default.
• W2802022785 created "2018-05-17" @default.
• W2802022785 creator A5023756614 @default.
• W2802022785 creator A5034652489 @default.
• W2802022785 creator A5026489547 @default.
• W2802022785 date "2019-03-01" @default.
• W2802022785 modified "2023-09-25" @default.
• W2802022785 title "Perioperative β-Adrenergic Blockade in Noncardiac and Cardiac Surgery: A Clinical Update" @default.
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