FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802023666> ?p ?o ?g. }

• W2802023666 endingPage "630" @default.
• W2802023666 startingPage "621" @default.
• W2802023666 abstract "Status epilepticus (SE) can result in an overproduction of hydrogen peroxide (H2O2), which contributes to oxidative stress and brain injury during different phases of epileptogenesis and seizures. In this study, we measured the extracellular H2O2 concentration in the rat hippocampus in a temporal lobe epilepsy model. A new fluorescent technique for measuring H2O2 in vivo simultaneously with electroencephalography recording was tested. The method consists of mixing microdialysate with an enzymatic reactor to produce a fluorescent compound. The fluorescence intensity was measured every second and was proportional to the H2O2 concentration. The results showed that H2O2 was released during SE; we detected a significant increase of up to five times over the baseline value that correlated with changes in electrical activity. We also observed that H2O2 was produced for days after SE and was associated with continuous neuronal death and seizure generation. Therefore, we monitored H2O2 48 h and 15 days after SE, observing increases of up to 96 and 124%, respectively, accompanied by changes in electrical activity with spontaneous discharges of large amplitude. These changes may reflect the oxidative stress generated during epileptogenesis that remains during the chronic period (458% increased) with the presence of large spikes, indicating that the H2O2 could also participate in the generation and maintenance of spontaneous recurrent seizures. There are no previous reports on the detection of H2O2 at this temporal resolution; thus, this study contributes a novel technique for studying and understanding epileptogenesis to develop new antioxidant strategies for the treatment of temporal lobe epilepsy." @default.
• W2802023666 created "2018-05-17" @default.
• W2802023666 creator A5012343805 @default.
• W2802023666 creator A5044939851 @default.
• W2802023666 creator A5062943482 @default.
• W2802023666 creator A5090330010 @default.
• W2802023666 date "2018-05-23" @default.
• W2802023666 modified "2023-09-26" @default.
• W2802023666 title "A novel online fluorescence method for in-vivo measurement of hydrogen peroxide during oxidative stress produced in a temporal lobe epilepsy model" @default.
• W2802023666 cites W1248697292 @default.
• W2802023666 cites W1591352074 @default.
• W2802023666 cites W1844162254 @default.
• W2802023666 cites W1851936662 @default.
• W2802023666 cites W1986078216 @default.
• W2802023666 cites W2007622668 @default.
• W2802023666 cites W2022330347 @default.
• W2802023666 cites W2025681573 @default.
• W2802023666 cites W2032578724 @default.
• W2802023666 cites W2050422609 @default.
• W2802023666 cites W2068078405 @default.
• W2802023666 cites W2072881200 @default.
• W2802023666 cites W2078025529 @default.
• W2802023666 cites W2085167867 @default.
• W2802023666 cites W2098773426 @default.
• W2802023666 cites W2207910629 @default.
• W2802023666 cites W2265458343 @default.
• W2802023666 cites W2321556243 @default.
• W2802023666 cites W2418807401 @default.
• W2802023666 cites W2490839939 @default.
• W2802023666 cites W2522828082 @default.
• W2802023666 cites W2607399492 @default.
• W2802023666 cites W2737467769 @default.
• W2802023666 cites W2748480491 @default.
• W2802023666 cites W972099853 @default.
• W2802023666 doi "https://doi.org/10.1097/wnr.0000000000001007" @default.
• W2802023666 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29596151" @default.
• W2802023666 hasPublicationYear "2018" @default.
• W2802023666 type Work @default.
• W2802023666 sameAs 2802023666 @default.
• W2802023666 citedByCount "14" @default.
• W2802023666 countsByYear W28020236662019 @default.
• W2802023666 countsByYear W28020236662020 @default.
• W2802023666 countsByYear W28020236662022 @default.
• W2802023666 countsByYear W28020236662023 @default.
• W2802023666 crossrefType "journal-article" @default.
• W2802023666 hasAuthorship W2802023666A5012343805 @default.
• W2802023666 hasAuthorship W2802023666A5044939851 @default.
• W2802023666 hasAuthorship W2802023666A5062943482 @default.
• W2802023666 hasAuthorship W2802023666A5090330010 @default.
• W2802023666 hasConcept C12554922 @default.
• W2802023666 hasConcept C150903083 @default.
• W2802023666 hasConcept C15744967 @default.
• W2802023666 hasConcept C169760540 @default.
• W2802023666 hasConcept C185592680 @default.
• W2802023666 hasConcept C207001950 @default.
• W2802023666 hasConcept C2776151105 @default.
• W2802023666 hasConcept C2777341932 @default.
• W2802023666 hasConcept C2778186239 @default.
• W2802023666 hasConcept C2781099131 @default.
• W2802023666 hasConcept C2781161787 @default.
• W2802023666 hasConcept C42219234 @default.
• W2802023666 hasConcept C522805319 @default.
• W2802023666 hasConcept C533411734 @default.
• W2802023666 hasConcept C55493867 @default.
• W2802023666 hasConcept C57236427 @default.
• W2802023666 hasConcept C71924100 @default.
• W2802023666 hasConcept C86803240 @default.
• W2802023666 hasConceptScore W2802023666C12554922 @default.
• W2802023666 hasConceptScore W2802023666C150903083 @default.
• W2802023666 hasConceptScore W2802023666C15744967 @default.
• W2802023666 hasConceptScore W2802023666C169760540 @default.
• W2802023666 hasConceptScore W2802023666C185592680 @default.
• W2802023666 hasConceptScore W2802023666C207001950 @default.
• W2802023666 hasConceptScore W2802023666C2776151105 @default.
• W2802023666 hasConceptScore W2802023666C2777341932 @default.
• W2802023666 hasConceptScore W2802023666C2778186239 @default.
• W2802023666 hasConceptScore W2802023666C2781099131 @default.
• W2802023666 hasConceptScore W2802023666C2781161787 @default.
• W2802023666 hasConceptScore W2802023666C42219234 @default.
• W2802023666 hasConceptScore W2802023666C522805319 @default.
• W2802023666 hasConceptScore W2802023666C533411734 @default.
• W2802023666 hasConceptScore W2802023666C55493867 @default.
• W2802023666 hasConceptScore W2802023666C57236427 @default.
• W2802023666 hasConceptScore W2802023666C71924100 @default.
• W2802023666 hasConceptScore W2802023666C86803240 @default.
• W2802023666 hasIssue "8" @default.
• W2802023666 hasLocation W28020236661 @default.
• W2802023666 hasLocation W28020236662 @default.
• W2802023666 hasOpenAccess W2802023666 @default.
• W2802023666 hasPrimaryLocation W28020236661 @default.
• W2802023666 hasRelatedWork W1125507816 @default.
• W2802023666 hasRelatedWork W2004017387 @default.
• W2802023666 hasRelatedWork W2024721689 @default.
• W2802023666 hasRelatedWork W2063228636 @default.
• W2802023666 hasRelatedWork W2071703460 @default.
• W2802023666 hasRelatedWork W2328490218 @default.
• W2802023666 hasRelatedWork W4200520141 @default.
• W2802023666 hasRelatedWork W4308523222 @default.

• next