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- W2802023981 abstract "Bullous pemphigoid (BP) can coexist with neurodegenerative diseases (ND) and malignancy, but the nature of such coexistences is still rather speculative. Here, we comparatively analyzed the occurrence of IgG antibodies to BP180 (BP180abs) and BP230 (BP230abs) as well as so-called onconeural IgG antibodies (onrlabs) in ethnic Slavs with coexistent BP and ND in relation to BP with underlying malignancy. Sera of 30 BP patients with concominant ND (BP+ND) and 30 BP patients without ND (BP-ND) were examined with ELISA for BP180abs and BP230abs and with immunoblotting for onrlabs to the following antigens: titin, SOX1, recoverin, Hu, Yo, Ri, PNMA2, CRMP-5 and amphiphysin. Results were analyzed statistically. Of correlations measured, negative correlations found in BP+ND patients between the presence of BP180abs and anti-Yo antibodies (r=-0.430, p=0.0318) and in BP-ND patients between the presence of BP180abs and anti-CRMP-5 antibodies (r=-0.402, p=0.0308) were the only statistically significant ones. Of onrlabs analyzed, anti-PNMA2 antibodies exhibited the biggest, albeit statistically insignificant (difference test between two proportions, p=0.1534), difference in occurrence in BP+ND patients (13%) and BP-ND patients (3%). Since none of BP+ND patients having positive onrlabs had overt malignancy and none of BP-ND patients with malignancy had positive onrlabs, it is just speculated that in certain ethnic Slavs, as a PNMA2 binary interaction with COL4A3BP is mentioned in biological databases, such PNMA2-collagens coactions might be associated with the coexistence of BP with ND irrespective of malignancy." @default.
- W2802023981 created "2018-05-17" @default.
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- W2802023981 date "2018-05-01" @default.
- W2802023981 modified "2023-09-28" @default.
- W2802023981 title "256 Comparative analysis of occurrence of IgG antibodies to BP180/BP230 and so-called onconeural IgG antibodies in ethnic Slavs with coexistent bullous pemphigoid and neurodegenerative diseases" @default.
- W2802023981 doi "https://doi.org/10.1016/j.jid.2018.03.262" @default.
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