FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802029328> ?p ?o ?g. }

• W2802029328 abstract "Preeclampsia (PE), associates with long-term increased risk for cardiovascular disease in women, suggesting that PE is not an isolated disease of pregnancy. It is not known if increased risk for long-term diseases is due to PE-specific factors or to prepregnancy renal and cardiovascular risk factors. We used a mouse model in which a WT female with normal prepregnancy health develops PE to investigate if preeclampsia causes long-term cardiovascular consequences after pregnancy for mothers and offspring. Mothers exhibited endothelial dysfunction and hypertension after PE and had glomerular injury that not only persisted but deteriorated, leading to fibrosis. Left ventricular (LV) remodeling characterized by increased collagen deposition and MMP-9 expression and enlarged cardiomyocytes were also detected after PE. Increased LV internal wall thickness and mass, increased end diastolic and end systolic volumes, and increased stroke volume were observed after PE in the mothers. Placenta-derived bioactive factors that modulate vascular function, markers of metabolic disease, vasoconstrictor isoprostane-8, and proinflammatory mediators were increased in sera during and after a preeclamptic pregnancy in the mother. Offspring of PE mice developed endothelial dysfunction, hypertension, and signs of metabolic disease. Microglia activation was increased in the neonatal brains after PE, suggesting neurogenic hypertension in offspring. Prevention of placental insufficiency with pravastatin prevented PE-associated cardiovascular complications in both mothers and offspring. In conclusion, factors that develop during PE have long-term, cardiovascular effects in the mother and offspring independent of prepregnancy risk factors." @default.
• W2802029328 created "2018-05-17" @default.
• W2802029328 creator A5006661431 @default.
• W2802029328 creator A5013097112 @default.
• W2802029328 creator A5021815852 @default.
• W2802029328 creator A5044078773 @default.
• W2802029328 creator A5049842471 @default.
• W2802029328 creator A5075055269 @default.
• W2802029328 date "2018-04-19" @default.
• W2802029328 modified "2023-10-16" @default.
• W2802029328 title "Pravastatin therapy during preeclampsia prevents long-term adverse health effects in mice" @default.
• W2802029328 cites W1771974095 @default.
• W2802029328 cites W1892857304 @default.
• W2802029328 cites W1893732205 @default.
• W2802029328 cites W1963940192 @default.
• W2802029328 cites W1968002331 @default.
• W2802029328 cites W1972710477 @default.
• W2802029328 cites W1976363248 @default.
• W2802029328 cites W1979765051 @default.
• W2802029328 cites W1981852225 @default.
• W2802029328 cites W1982254799 @default.
• W2802029328 cites W1987403942 @default.
• W2802029328 cites W1988820738 @default.
• W2802029328 cites W1993286003 @default.
• W2802029328 cites W1997652121 @default.
• W2802029328 cites W2002895331 @default.
• W2802029328 cites W2003071296 @default.
• W2802029328 cites W2005848269 @default.
• W2802029328 cites W2014193833 @default.
• W2802029328 cites W2018891761 @default.
• W2802029328 cites W2023685096 @default.
• W2802029328 cites W2031848598 @default.
• W2802029328 cites W2036213751 @default.
• W2802029328 cites W2036357650 @default.
• W2802029328 cites W2041568757 @default.
• W2802029328 cites W2051213492 @default.
• W2802029328 cites W2054523815 @default.
• W2802029328 cites W2065321720 @default.
• W2802029328 cites W2068382689 @default.
• W2802029328 cites W2072625807 @default.
• W2802029328 cites W2074603870 @default.
• W2802029328 cites W2090337062 @default.
• W2802029328 cites W2095687105 @default.
• W2802029328 cites W2098320419 @default.
• W2802029328 cites W2102650615 @default.
• W2802029328 cites W2104732966 @default.
• W2802029328 cites W2107327854 @default.
• W2802029328 cites W2107839246 @default.
• W2802029328 cites W2108748211 @default.
• W2802029328 cites W2110740921 @default.
• W2802029328 cites W2111433735 @default.
• W2802029328 cites W2115547580 @default.
• W2802029328 cites W2136047500 @default.
• W2802029328 cites W2137020418 @default.
• W2802029328 cites W2140369420 @default.
• W2802029328 cites W2141407971 @default.
• W2802029328 cites W2143360356 @default.
• W2802029328 cites W2155504581 @default.
• W2802029328 cites W2169182236 @default.
• W2802029328 cites W2210639700 @default.
• W2802029328 cites W2223012464 @default.
• W2802029328 cites W2272024469 @default.
• W2802029328 cites W2413416789 @default.
• W2802029328 cites W2464509388 @default.
• W2802029328 cites W2466251702 @default.
• W2802029328 cites W2494545820 @default.
• W2802029328 cites W2511363188 @default.
• W2802029328 cites W2513919347 @default.
• W2802029328 cites W2524166045 @default.
• W2802029328 cites W2572178740 @default.
• W2802029328 cites W4233022333 @default.
• W2802029328 cites W4244876089 @default.
• W2802029328 cites W4254913758 @default.
• W2802029328 doi "https://doi.org/10.1172/jci.insight.120147" @default.
• W2802029328 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5931129" @default.
• W2802029328 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29669946" @default.
• W2802029328 hasPublicationYear "2018" @default.
• W2802029328 type Work @default.
• W2802029328 sameAs 2802029328 @default.
• W2802029328 citedByCount "30" @default.
• W2802029328 countsByYear W28020293282019 @default.
• W2802029328 countsByYear W28020293282020 @default.
• W2802029328 countsByYear W28020293282021 @default.
• W2802029328 countsByYear W28020293282022 @default.
• W2802029328 countsByYear W28020293282023 @default.
• W2802029328 crossrefType "journal-article" @default.
• W2802029328 hasAuthorship W2802029328A5006661431 @default.
• W2802029328 hasAuthorship W2802029328A5013097112 @default.
• W2802029328 hasAuthorship W2802029328A5021815852 @default.
• W2802029328 hasAuthorship W2802029328A5044078773 @default.
• W2802029328 hasAuthorship W2802029328A5049842471 @default.
• W2802029328 hasAuthorship W2802029328A5075055269 @default.
• W2802029328 hasBestOaLocation W28020293281 @default.
• W2802029328 hasConcept C112672928 @default.
• W2802029328 hasConcept C126322002 @default.
• W2802029328 hasConcept C134018914 @default.
• W2802029328 hasConcept C2777218350 @default.
• W2802029328 hasConcept C2778163477 @default.
• W2802029328 hasConcept C2779134260 @default.
• W2802029328 hasConcept C2779234561 @default.

• next