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- W2802043942 abstract "Nearly isogenic substrains provide a simplified system for identification and validation of functional variants and the individual contributions of genes to complex traits. A reduced complexity cross (RCC) is generated by mating closely related substrains followed by crossing of the resulting F1 progeny to generate a recombinant F2 population. The resulting RCC segregates genetic variants that underlie phenotypic differences between parental strains. Genetic mapping is used to statistically isolate genomic regions containing the causal variants. In a typical F2 cross, these genomic regions contain hundreds of polymorphic genes and several thousand variants. In contrast, while the genomic regions in an RCC are similarly sized, they contain orders of magnitude fewer candidate genetic variants, thus facilitating causal gene identification. Here, we review the methodology and design of a novel forward genetics strategy in RCCs, including rapid fine mapping of Mendelian traits in F2 recombinant individuals, to maximize the efficiency by which genetic factors underlying trait variation can be rapidly identified. We use C57BL/6 substrains, and other nearly isogenic models, as examples of how to harness the phenotypic diversity of the RCC to precisely map, validate, and define the genetic and biologic mechanisms that account for this phenotypic diversity." @default.
- W2802043942 created "2018-05-17" @default.
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- W2802043942 date "2018-01-01" @default.
- W2802043942 modified "2023-10-17" @default.
- W2802043942 title "Reduced Complexity Cross Design for Behavioral Genetics" @default.
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- W2802043942 doi "https://doi.org/10.1016/b978-0-12-804078-2.00008-8" @default.
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