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• W2802049299 abstract "BackgroundA subgroup of patients with common variable immunodeficiencies (CVIDs) responds to vaccination. The aim of this study was to try to identify predictive markers for those with a humoral immune response after influenza vaccination.MethodsForty-eight patients with CVID (29 female and 19 male patients; mean age, 57.7 years) were vaccinated with the A(H1N1) influenza vaccine Pandemrix (GlaxoSmithKline, Wavre, Belgium) and boosted after 1 month. Blood samples were collected before each vaccination and 2 months later. Patients with a 4-fold titer increase in results on the hemagglutinin inhibition test (≥1:40) were considered responders and compared with nonresponders for clinical, immunologic, and genetic markers.ResultsEight (16.7%) patients responded to the vaccination. A significantly higher proportion of the responders, who showed a EUROclass SmB−Trnorm21norm profile (P = .03) with a post–germinal center B-cell pattern (P = .04) in blood, experienced enteropathies (P = .04) compared with nonresponders. On the other hand, bronchiectasis was found exclusively among nonresponders (n = 7), as was autoimmune cytopenia (n = 5). Nonresponders with a EUROclass SmB−Trnorm21low profile (P = .02) had a significantly greater prevalence of progressive antibody deficiency (P = .048) and, at diagnosis, a higher mean serum IgM level (P = .03), lower mean serum IgG1 level (P = .007), expansion of absolute counts of cytotoxic CD8+ T cells (P = .033), and increased proportion of memory CD8+ T cells (P = .044) in blood. CVID-associated HLA markers were not detected in responders (P = .03).ConclusionAbout one fifth of the patients with CVIDs achieved protective antibody levels after A(H1N1) vaccination and selected clinical, and immunologic markers were identified that might predict a positive outcome of influenza vaccination. Patients with CVID should be offered vaccination also against seasonal influenza because of the potential severity of the infection and risk for bacterial complications. A subgroup of patients with common variable immunodeficiencies (CVIDs) responds to vaccination. The aim of this study was to try to identify predictive markers for those with a humoral immune response after influenza vaccination. Forty-eight patients with CVID (29 female and 19 male patients; mean age, 57.7 years) were vaccinated with the A(H1N1) influenza vaccine Pandemrix (GlaxoSmithKline, Wavre, Belgium) and boosted after 1 month. Blood samples were collected before each vaccination and 2 months later. Patients with a 4-fold titer increase in results on the hemagglutinin inhibition test (≥1:40) were considered responders and compared with nonresponders for clinical, immunologic, and genetic markers. Eight (16.7%) patients responded to the vaccination. A significantly higher proportion of the responders, who showed a EUROclass SmB−Trnorm21norm profile (P = .03) with a post–germinal center B-cell pattern (P = .04) in blood, experienced enteropathies (P = .04) compared with nonresponders. On the other hand, bronchiectasis was found exclusively among nonresponders (n = 7), as was autoimmune cytopenia (n = 5). Nonresponders with a EUROclass SmB−Trnorm21low profile (P = .02) had a significantly greater prevalence of progressive antibody deficiency (P = .048) and, at diagnosis, a higher mean serum IgM level (P = .03), lower mean serum IgG1 level (P = .007), expansion of absolute counts of cytotoxic CD8+ T cells (P = .033), and increased proportion of memory CD8+ T cells (P = .044) in blood. CVID-associated HLA markers were not detected in responders (P = .03). About one fifth of the patients with CVIDs achieved protective antibody levels after A(H1N1) vaccination and selected clinical, and immunologic markers were identified that might predict a positive outcome of influenza vaccination. Patients with CVID should be offered vaccination also against seasonal influenza because of the potential severity of the infection and risk for bacterial complications." @default.
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• W2802049299 date "2018-12-01" @default.
• W2802049299 modified "2023-10-17" @default.
• W2802049299 title "Predictive markers for humoral influenza vaccine response in patients with common variable immunodeficiency" @default.
• W2802049299 cites W1515389128 @default.
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• W2802049299 cites W1575665885 @default.
• W2802049299 cites W1791498330 @default.
• W2802049299 cites W1960890728 @default.
• W2802049299 cites W1964369102 @default.
• W2802049299 cites W1967061388 @default.
• W2802049299 cites W1969457222 @default.
• W2802049299 cites W1977467447 @default.
• W2802049299 cites W1981021485 @default.
• W2802049299 cites W1984135028 @default.
• W2802049299 cites W1991130982 @default.
• W2802049299 cites W1994133262 @default.
• W2802049299 cites W1999835352 @default.
• W2802049299 cites W2002600455 @default.
• W2802049299 cites W2002612948 @default.
• W2802049299 cites W2007954723 @default.
• W2802049299 cites W2010895610 @default.
• W2802049299 cites W2015992070 @default.
• W2802049299 cites W2023210663 @default.
• W2802049299 cites W2024860738 @default.
• W2802049299 cites W2024897191 @default.
• W2802049299 cites W2027559303 @default.
• W2802049299 cites W2038264470 @default.
• W2802049299 cites W2041522678 @default.
• W2802049299 cites W2043866118 @default.
• W2802049299 cites W2048719770 @default.
• W2802049299 cites W2054145737 @default.
• W2802049299 cites W2060861817 @default.
• W2802049299 cites W2065293336 @default.
• W2802049299 cites W2077625594 @default.
• W2802049299 cites W2082250139 @default.
• W2802049299 cites W2083839173 @default.
• W2802049299 cites W2085572908 @default.
• W2802049299 cites W2095505747 @default.
• W2802049299 cites W2106278908 @default.
• W2802049299 cites W2111137836 @default.
• W2802049299 cites W2111683145 @default.
• W2802049299 cites W2118643773 @default.
• W2802049299 cites W2126359181 @default.
• W2802049299 cites W2132204826 @default.
• W2802049299 cites W2134178858 @default.
• W2802049299 cites W2141999252 @default.
• W2802049299 cites W2144242300 @default.
• W2802049299 cites W2150035599 @default.
• W2802049299 cites W2156009342 @default.
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• W2802049299 doi "https://doi.org/10.1016/j.jaci.2018.02.052" @default.
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