FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802061036> ?p ?o ?g. }

• W2802061036 endingPage "4908" @default.
• W2802061036 startingPage "4903" @default.
• W2802061036 abstract "Significance Delivery remains a significant challenge for robust implementation of CRISPR/Cas9. We report an efficient CRISPR/Cas9 delivery system comprising PEGylated nanoparticles based on the α-helical polypeptide PPABLG. Assisted by the high membrane-penetrating ability of the polypeptide, P-HNPs achieved efficient cellular internalization and endosomal escape. The CRISPR/Cas9 delivery system could reach 47.3% gene editing in cells, 35% gene deletion in vivo, and HeLa tumor growth suppression >71%, demonstrating an advantage over the existing conventional polycationic transfection reagents. Efficient also in knock-in and gene activation, the reported CRISPR/Cas9 delivery system serves to advance gene editing in vitro and in vivo." @default.
• W2802061036 created "2018-05-17" @default.
• W2802061036 creator A5009440227 @default.
• W2802061036 creator A5019444828 @default.
• W2802061036 creator A5021226984 @default.
• W2802061036 creator A5038759638 @default.
• W2802061036 creator A5050337091 @default.
• W2802061036 creator A5054535182 @default.
• W2802061036 creator A5060491996 @default.
• W2802061036 creator A5061954008 @default.
• W2802061036 creator A5062713630 @default.
• W2802061036 creator A5064591982 @default.
• W2802061036 creator A5070584346 @default.
• W2802061036 creator A5081513362 @default.
• W2802061036 date "2018-04-23" @default.
• W2802061036 modified "2023-10-17" @default.
• W2802061036 title "Nonviral gene editing via CRISPR/Cas9 delivery by membrane-disruptive and endosomolytic helical polypeptide" @default.
• W2802061036 cites W1975687482 @default.
• W2802061036 cites W1979659851 @default.
• W2802061036 cites W1996788258 @default.
• W2802061036 cites W2039551908 @default.
• W2802061036 cites W2041105700 @default.
• W2802061036 cites W2061650108 @default.
• W2802061036 cites W2063780640 @default.
• W2802061036 cites W2073217307 @default.
• W2802061036 cites W2075279905 @default.
• W2802061036 cites W2076183717 @default.
• W2802061036 cites W2083731850 @default.
• W2802061036 cites W2093198351 @default.
• W2802061036 cites W2096261947 @default.
• W2802061036 cites W2096751725 @default.
• W2802061036 cites W2103609218 @default.
• W2802061036 cites W2107237747 @default.
• W2802061036 cites W2114042611 @default.
• W2802061036 cites W2123238521 @default.
• W2802061036 cites W2140000006 @default.
• W2802061036 cites W2140022328 @default.
• W2802061036 cites W2149142532 @default.
• W2802061036 cites W2260024370 @default.
• W2802061036 cites W2269090499 @default.
• W2802061036 cites W2292390328 @default.
• W2802061036 cites W2443086882 @default.
• W2802061036 cites W2552166386 @default.
• W2802061036 cites W2560987571 @default.
• W2802061036 cites W2581151188 @default.
• W2802061036 cites W2611069492 @default.
• W2802061036 cites W2667943050 @default.
• W2802061036 cites W2750589492 @default.
• W2802061036 cites W2783304391 @default.
• W2802061036 cites W333206344 @default.
• W2802061036 doi "https://doi.org/10.1073/pnas.1712963115" @default.
• W2802061036 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5948953" @default.
• W2802061036 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29686087" @default.
• W2802061036 hasPublicationYear "2018" @default.
• W2802061036 type Work @default.
• W2802061036 sameAs 2802061036 @default.
• W2802061036 citedByCount "213" @default.
• W2802061036 countsByYear W28020610362018 @default.
• W2802061036 countsByYear W28020610362019 @default.
• W2802061036 countsByYear W28020610362020 @default.
• W2802061036 countsByYear W28020610362021 @default.
• W2802061036 countsByYear W28020610362022 @default.
• W2802061036 countsByYear W28020610362023 @default.
• W2802061036 crossrefType "journal-article" @default.
• W2802061036 hasAuthorship W2802061036A5009440227 @default.
• W2802061036 hasAuthorship W2802061036A5019444828 @default.
• W2802061036 hasAuthorship W2802061036A5021226984 @default.
• W2802061036 hasAuthorship W2802061036A5038759638 @default.
• W2802061036 hasAuthorship W2802061036A5050337091 @default.
• W2802061036 hasAuthorship W2802061036A5054535182 @default.
• W2802061036 hasAuthorship W2802061036A5060491996 @default.
• W2802061036 hasAuthorship W2802061036A5061954008 @default.
• W2802061036 hasAuthorship W2802061036A5062713630 @default.
• W2802061036 hasAuthorship W2802061036A5064591982 @default.
• W2802061036 hasAuthorship W2802061036A5070584346 @default.
• W2802061036 hasAuthorship W2802061036A5081513362 @default.
• W2802061036 hasBestOaLocation W28020610361 @default.
• W2802061036 hasConcept C102747710 @default.
• W2802061036 hasConcept C104317684 @default.
• W2802061036 hasConcept C111599444 @default.
• W2802061036 hasConcept C132455925 @default.
• W2802061036 hasConcept C135983454 @default.
• W2802061036 hasConcept C139770010 @default.
• W2802061036 hasConcept C144501496 @default.
• W2802061036 hasConcept C1491633281 @default.
• W2802061036 hasConcept C207001950 @default.
• W2802061036 hasConcept C54009773 @default.
• W2802061036 hasConcept C54355233 @default.
• W2802061036 hasConcept C70721500 @default.
• W2802061036 hasConcept C79879829 @default.
• W2802061036 hasConcept C86803240 @default.
• W2802061036 hasConcept C95444343 @default.
• W2802061036 hasConcept C98108389 @default.
• W2802061036 hasConceptScore W2802061036C102747710 @default.
• W2802061036 hasConceptScore W2802061036C104317684 @default.
• W2802061036 hasConceptScore W2802061036C111599444 @default.
• W2802061036 hasConceptScore W2802061036C132455925 @default.
• W2802061036 hasConceptScore W2802061036C135983454 @default.

• next