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- W2802078840 abstract "The nucleosome is the basic structure of chromatin in eukaryotic cells, with essential roles in the regulation of many biological processes, such as DNA transcription, replication and repair, and RNA splicing. Because of the importance of nucleosomes, the factors that determine their positioning within genomes should be investigated. High-resolution nucleosome-positioning maps are now available for organisms including Saccharomyces cerevisiae, Drosophila melanogaster and Caenorhabditis elegans, enabling the identification of nucleosome positioning by application of computational tools. Here, we describe a novel predictor called NucPosPred, which was specifically designed for large-scale identification of nucleosome positioning in C. elegans and D. melanogaster genomes. NucPosPred was separately optimized for each species for four types of DNA sequence feature extraction, with consideration of two classification algorithms (gradient-boosting decision tree and support vector machine). The overall accuracy obtained with NucPosPred was 92.29% for C. elegans and 88.26% for D. melanogaster, outperforming previous methods and demonstrating the potential for species-specific prediction of nucleosome positioning. For the convenience of most experimental scientists, a web-server for the predictor NucPosPred is available at http://121.42.167.206/NucPosPred/index.jsp." @default.
- W2802078840 created "2018-05-17" @default.
- W2802078840 creator A5017426085 @default.
- W2802078840 creator A5066126756 @default.
- W2802078840 creator A5085426866 @default.
- W2802078840 date "2018-08-01" @default.
- W2802078840 modified "2023-10-03" @default.
- W2802078840 title "NucPosPred: Predicting species-specific genomic nucleosome positioning via four different modes of general PseKNC" @default.
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- W2802078840 doi "https://doi.org/10.1016/j.jtbi.2018.04.025" @default.
- W2802078840 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29678692" @default.
- W2802078840 hasPublicationYear "2018" @default.
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